A5038498656- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Actinomycetales infections and treatment
- Cerebral Venous Sinus Thrombosis
- Connective tissue disorders research
- History of Medical Practice
- Craniofacial Disorders and Treatments
- Management of metastatic bone disease
- Acute Ischemic Stroke Management
- Global Health Workforce Issues
- Cardiovascular and Diving-Related Complications
- Head and Neck Surgical Oncology
- Facial Trauma and Fracture Management
The University of Adelaide
2004-2025
Royal Adelaide Hospital
2002-2020
Penn Presbyterian Medical Center
2020
Oak Ridge National Laboratory
2009
Gallagher (United States)
2008
Royal Darwin Hospital
2005
Flinders University
2005
Gainesville Obstetrics & Gynecology
2001
South Australia Pathology
1994-1999
Royal Society Te Apārangi
1992
It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumatic brain injury and refractory raised intracranial pressure.From December 2002 through April 2010, we randomly assigned 155 adults diffuse hypertension that was to first-tier therapies undergo either bifrontotemporoparietal or standard care. The original primary an unfavorable (a composite of death, vegetative state, disability), as evaluated on Extended Glasgow Outcome Scale 6...
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has explored. In this study, we report use whole exome sequencing (WES) seven densely-affected families (45 individuals) recruited as part Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and...
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In trial, patients randomly allocated 1:1 to either or intensive medical therapies (standard care). We conducted planned analyses 6 months, including all 155 patients. measured functional using Glasgow Outcome Scale-Extended (GOS-E). used ordered logistic regression, dichotomized GOS-E...
Objective To compare continuous jugular venous bulb oximetry and cerebral near-infrared spectroscopy in patients with severe closed head injury. Design A prospective observational study. Setting Intensive care unit of a major teaching hospital. Patients Adults (n = 10) closed-head injury (Glasgow Coma Scale score <or=to8). Interventions None. Measurements Main Results Jugular oximetry, spectroscopy, perfusion pressure were measured continuously. total 3,691 paired measurements analyzed. Poor...
Many bubbles that enter the brain circulation pass through arterioles and capillary beds do not obstruct blood flow. Nevertheless, such could still disrupt function. An open-brain model in five anesthetized rabbits used minimum dose of air (25 microliters) necessary to cause embolism exposed vessels, these passed vessels without any trapping. Despite their rapid transit, provoked a marked dilatation affected pial (mean increase after 15 minutes 27%) persisted for 90 had disappeared. The...
Abstract Fluid-coupled recording systems are the most popular method of intracranial pressure (ICP), but they can be prone to blockage and infection. A series 378 recordings ICP was analyzed identify complications cases in which had discontinued prematurely because catheter blockage. Three different methods were used: a ventricular catheter, Richmond screw, subdural catheter. screws became blocked more often (16%) than catheters (2.7%) or (2.5%). Complications infection intracerebral...
"Syndrome of the trephined" or "sinking skin flap syndrome" is an unusual syndrome in which neurological deterioration occurs following removal a large skull bone flap. The status patient can occasionally be strongly related to posture. A 77-year-old male with acute subdural hematoma was treated using hemicraniectomy and evacuation hematoma. On 9th postoperative day there sensorium associated sunken scalp worsening midline shift on CT. significant improvement filling up occurred after...
Axonal injury (AI), one of the principal determinants clinical outcome after head injury, may evolve over several hours raising future possibility therapeutic intervention during this period. A new impact model AI in sheep was developed to examine pathological and physiological changes brain resulting from a graded traumatic insult. In preliminary study 10 anesthetized ventilated Merino ewes were used. Head produced by humane stunner temporal region an unrestrained head. Eight studied for 1,...
Nocardial brain abscesses are associated with significant morbidity and mortality rates. The optimal management remains unclear. We reviewed the surgical outcomes of patients treated a relatively uniform policy at single institution.Eleven were Royal Adelaide Hospital between 1970 2001. Their clinical presentations, treatment, reviewed.Clinical presentations most frequently involved focal neurological deficits (91%). Predisposing factors identified for 63% patients. Nine only aspiration...
We studied the natural history of brain air embolism by observing bubbles in pial vessels rabbits and effect different doses intracarotid on function blood flow. identified then two air; 25 microliters five caused rapid bubble transit, recovery, deterioration flow 400 temporary trapping sustained function. These dose responses correlate well with divers brain. All both arteriolar dilatation reduced flow, which were independent dose, whereas detrimental was dependent. Our results suggest that...
A prospective observational study was performed to assess the reliability of fibreoptic oximetric catheters and identify incidence causes jugular bulb oxygen desaturation in patients with acute closed head injury. There were twenty- five (30± 16 years) GCS ≤8 this study. Jugular oximetry, mean arterial pressure, intracranial end-tidal CO 2 pulse oximetry monitored continuously. Catheter calibration against a laboratory oximeter post insertion thereafter eight-hourly. Cerebral venous defined...
Background: Due to the geographical remoteness of Darwin, which has no resident neurosurgeon, emergency transfer patients for neurosurgery is usually impractical. In Darwin must be undertaken by general surgeons. Methods: Data from operating theatre, Emergency Department and Intensive Care Unit were prospectively recorded on all who underwent an neurosurgical procedure between January 1992 June 2004. Outcomes assessed retrospective case note review. Results: Three hundred five procedures...
The aim of these studies was to assess and quantitate the effects cyclosporin-A (CyA) on brain APP messenger RNA neuronal perikaryal antigen expression following controlled focal head impact in sheep. Impact results a significant increase both mRNA expression. Post-traumatic administration CyA (intrathecal 10 mg/kg) resulted reduction At 2 h postinjury, treatment caused statistically (p < 0.05) 1.3 ± 0.1-fold decrease central gray matter impacted sheep compared untreated A more profound...