A5090251647- Avian ecology and behavior
- Traumatic Brain Injury and Neurovascular Disturbances
- Wildlife Ecology and Conservation
- Intracranial Aneurysms: Treatment and Complications
- Metabolism, Diabetes, and Cancer
- Species Distribution and Climate Change
- S100 Proteins and Annexins
- Marine animal studies overview
- Diabetes Management and Research
- Traumatic Brain Injury Research
- Rangeland and Wildlife Management
- Cerebrospinal fluid and hydrocephalus
- Optical Imaging and Spectroscopy Techniques
- Fire effects on ecosystems
- Diabetes Treatment and Management
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cardiovascular and exercise physiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatic function and diabetes
- Moyamoya disease diagnosis and treatment
- Wildlife-Road Interactions and Conservation
- Vascular Malformations Diagnosis and Treatment
- Animal Behavior and Reproduction
- Muscle metabolism and nutrition
United States Fish and Wildlife Service
2015-2024
James Cook University
2021
Oxford University Press (United Kingdom)
2020
University of Florida
2005-2016
Neurological Surgery
2002-2016
King's College Hospital
2016
National Park Service
2016
Hollywood Orthopaedic Group
2015
Womack Army Medical Center
2013
Frenchay Hospital
2012
Aneurysms located on the distal portion of posterior inferior cerebellar artery (PICA) are uncommon, and their underlying pathology, natural history, clinical management poorly understood. To clarify these lesions more fully, authors undertook a retrospective analysis features results 22 PICA aneurysms in 20 consecutive patients treated at one institution by same surgeon during past decade.The series included 10 men women (mean age presentation 51 years). Nine presented with only...
Following traumatic brain injury (TBI), the cytoskeletal protein α-II-spectrin is proteolyzed by calpain and caspase-3 to signature breakdown products. To determine whether α -II-spectrin proteolysis a potentially reliable biomarker for TBI in humans, present study (1) examined levels of spectrin products (SBDPs) cerebrospinal fluid (CSF) from adults with severe (2) relationship between these levels, severity injury, clinical outcome. This prospective case control enrolled 41 patients TBI,...
The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production total ketones glucose was studied after an overnight fast in four normal five insulin-dependent diabetic men. Brachial artery hepatic vein catheters were inserted blood flow determined using indocyanine green. infusion resulted a mean circulating plasma level 4,420 pg/ml. In the subjects, stimulation insulin secretion indicated by rising levels immunoreactive C-peptide immunoreactivity....
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has explored. In this study, we report use whole exome sequencing (WES) seven densely-affected families (45 individuals) recruited as part Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and...
Ecological “big data” Human activities are rapidly altering the natural world. Nowhere is this more evident, perhaps, than in Arctic, yet region remains one of most remote and difficult to study. Researchers have increasingly relied on animal tracking data these regions understand individual species' responses, but if we want larger-scale change, need integrate our understanding across species. Davidson et al. introduce an open-source archive that currently hosts 15 million location points...
Abstract OBJECTIVE The treatment of giant intracranial aneurysms is a challenge because the limitations and difficulty direct surgical clipping endovascular coiling. We describe indications, technique, complications saphenous vein extracranial-to-intracranial bypass grafting followed by acute parent vessel occlusion in management these difficult lesions. METHODS Between January 1990 December 1999, 29 patients with underwent 30 grafts immediate occlusion. There were 11 men 18 women mean...
Objective To compare continuous jugular venous bulb oximetry and cerebral near-infrared spectroscopy in patients with severe closed head injury. Design A prospective observational study. Setting Intensive care unit of a major teaching hospital. Patients Adults (n = 10) closed-head injury (Glasgow Coma Scale score <or=to8). Interventions None. Measurements Main Results Jugular oximetry, spectroscopy, perfusion pressure were measured continuously. total 3,691 paired measurements analyzed. Poor...
OBJECTIVE Determining factors predictive of the natural risk rupture cerebral aneurysms is difficult because need to control for confounding variables. We studied associated with in a study model patients multiple aneurysms, one aneurysm that had ruptured and or more not, which each patient served as their own internal control. METHODS collected location, one-dimensional measurements, two-dimensional indices from computed tomographic angiograms proposed compared versus unruptured aneurysms....
OBJECTIVE There are few studies comparing the economic costs and reimbursements for aneurysm clipping versus coiling, none from United States. Our hypothesis predicted that coiling would result in shorter lengths of hospitalization than patients with unruptured aneurysms therefore lower hospital charges. However, because severity subarachnoid hemorrhage, there be no difference length or charges ruptured aneurysms. METHODS We compared treated at University Florida January 2005 to June 2007...
Seventy-two patients with gestational diabetes were randomly treated insulin (20 units NPH and 10 regular) diabetic diet, diet alone, or neither. Of the 27 2 (7%) had babies weighing more than 8½ pounds. 11 4 (36.4%) 34 neither nor insulin, 17 (50%) These data support hypothesis that treatment of will reduce incidence fetal macrosomia.
Traumatic brain injury (TBI) produces αII-spectrin breakdown products (SBDPs) that are potential biomarkers for TBI. To further understand these biomarkers, the present study examined (1) exposure and kinetic characteristics of SBDPs in cerebrospinal fluid (CSF) adults with severe TBI, (2) relationship between metrics severity injury. This clinical database analyzed CSF concentrations 150-, 145-, 120-kDa 38 TBI patients. Area under curve (AUC), mean residence time (MRT), maximum...
Insulin can modulate glucagon-stimulated hepatic glucose production and is considered to be the major factor acting in vivo exert a counterregulatory action glucagon. The insulindependent diabetic, therefore, might especially vulnerable enhanced promoted by To investigate this hypothesis, low-dose glucagon infusions were administered normal diabetic men compare effects of on net splanchnic (NSGP). Four three insulin-dependent, ketosis-prone, hyperglycemic (insulin withheld for 24 hours)...
BACKGROUND: External ventricular drainage (EVD) catheters provide reliable and accurate means of monitoring intracranial pressure alleviating elevated pressures via cerebrospinal fluid (CSF). CSF infections occur in approximately 9% patients. Antibiotic-impregnated (AI) EVD were developed with the goal reducing occurrence catheter-related their associated complications. OBJECTIVE: To present an international, prospective, randomized, open-label trial to evaluate infection incidence AI vs...
Abstract By using two different approaches, ubiquitin C‐terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage disease states. Appropriate antibodies sensitive ELISA were generated, the release UCHL1 into CSF compared with that pNF‐H S100β cohort 30 ASAH patients. Both showed persistent almost all patients second week postaneurysmal rupture (AR), levels...
Glucagon activates hepatic adenylate cyclase, thereby increasing acutely the liver content of cyclic AMP (cAMP) as well release cAMP into vein. Insulin, on other hand, antagonizes this glucagon-mediated production, thus providing a hypothetical mechanism through which insulin might correct some metabolic abnormalities diabetes. To study hormonal interaction in man, net splanchnic production (NScAMPP) was investigated normal and insulin-dependent diabetic men under basal conditions response...
Video recording of prey deliveries to nests is a new technique for collecting data on raptor diet, but no thorough comparison results from traditional methods based collections remains and pellets has been undertaken. We compared these 3 determine relative merits different assessing diet as part study the breeding-season northern goshawks (Accipiter gentilis) in Southeast Alaska. applied 5 during each goshawk breeding seasons 1998 1999 identified 1,540 deliveries, 209 remains, pellets. The...
Blood and cerebrospinal fluid (CSF) of 30 Fisher grade 3 aneurysmal subarachnoid hemorrhage (ASAH) patients were analyzed for the presence phosphorylated axonal form major neurofilament subunit NF-H (pNF-H), a promising biomarker injury. Patient demographic data including development vasospasm outcome scores at 6 months after rupture (AR) evaluated. Higher pNF-H blood levels in first few days AR strongly predictive negative outcome. most recovering showed steady increase into second week AR,...
Glucagon and/or the catecholamines elevate tissue cyclic adenylate (cAMP) and thereby change activity of a number metabolic processes, as studied in isolated perfused rat liver. Insulin can lower cAMP liver opposes these changes. In liver, basal state, there appears to be substantial quantity which is compartmentalized, unaffected by insulin physiologically inactive. The hormone effects are exerted on pool “free cAMP,” changes level this control minute-to-minute output glucose presumably...
Axonal injury (AI), one of the principal determinants clinical outcome after head injury, may evolve over several hours raising future possibility therapeutic intervention during this period. A new impact model AI in sheep was developed to examine pathological and physiological changes brain resulting from a graded traumatic insult. In preliminary study 10 anesthetized ventilated Merino ewes were used. Head produced by humane stunner temporal region an unrestrained head. Eight studied for 1,...
Use of genetic marks to identify individuals and generate population estimates using mark-recapture methodologies has become increasingly common. Recently, brown bear (Ursus arctos) have been made DNA isolated from hair follicles as the mark, obtaining with a barbed-wire enclosure around scent lure. While this method successfully used in low-density populations, it would be difficult use areas dense concentrations bears because high probability collecting multiple at single site during trap...