A5036139108- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Machine Learning in Bioinformatics
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Plant and Fungal Interactions Research
- Insect-Plant Interactions and Control
- Infectious Encephalopathies and Encephalitis
- Olfactory and Sensory Function Studies
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- interferon and immune responses
- bioluminescence and chemiluminescence research
- Entomopathogenic Microorganisms in Pest Control
- Colorectal Cancer Screening and Detection
- Plant Gene Expression Analysis
- Plant Virus Research Studies
Wuhan University
2012-2024
Florida State University
2016-2022
National Center for Advancing Translational Sciences
2022
National Taiwan University Hospital
2014
National Yang Ming Chiao Tung University
2013
National Yang Ming University Hospital
2013
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs development function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed Asian ZIKVC, African ZIKVM, dengue (DENV). In contrast the robust global transcriptome changes induced by DENV, a more selective larger impact on expression genes involved in DNA replication repair. While overall profiles are similar, but not induces...
Brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most destructive insects affecting rice production. To better understand physiological mechanisms how responds to BPH feeding, we analyzed BPH-induced transcriptomic and metabolic changes in leaf sheaths both BPH-susceptible -resistant varieties. Our results demonstrated that resistant reduced settling, feeding growth BPH. Metabolic analyses indicated infestation caused more drastic overall susceptible variety than rice....
Zika virus (ZIKV) and dengue (DENV) are two closely related flaviviruses that lead to different clinical outcomes. The mechanism for the distinct pathogenesis of ZIKV DENV is poorly understood. Here, we investigate infection macrophages using a human pluripotent stem cell (hPSC)-derived macrophage model discover key virus-specific responses. productively infect hPSC-derived macrophages. DENV, but not ZIKV, strongly activates migration inhibitory factor (MIF) secretion decreases migration....
The development of dengue antivirals and vaccine has been hampered by the incomplete understanding molecular mechanisms virus (DENV) infection pathology, partly due to limited suitable cell culture or animal models that can capture comprehensive cellular changes induced DENV. In this study, we differentiated human pluripotent stem cells (hPSCs) into hepatocytes, one target DENV, investigate various aspects DENV-hepatocyte interaction. hPSC-derived hepatocyte-like (HLCs) supported persistent...
Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these is poorly understood. We utilize induced pluripotent stem cell (iPSC)-derived human brain microvascular endothelial cells (iBMECs) study virus-blood-brain barrier (BBB) interactions. These iPSC-derived faithfully recapitulate striking difference vivo neuroinvasion two alphavirus isolates are...
Endosymbiotic fungi play an important role in the growth and development of insects. Understanding endosymbiont communities hosted by brown planthopper (BPH; Nilaparvata lugens Stål), most destructive pest rice, is a prerequisite for controlling BPH rice infestations. However, diversity dynamics remain poorly studied. Here, we used circular consensus sequencing (CCS) to obtain 87,131 OTUs (operational taxonomic units), which annotated 730 species endosymbiotic various developmental stages...
Zika virus (ZIKV) became a global health concern in 2016 due to its links congenital microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic reticulum (ER) form viroplasm, compartment where particles are assembled. Microtubules (MTs) microtubule-organizing centers (MTOCs) coordinate structural trafficking functions cell, MTs also support replication of flaviviruses. Here we investigated roles cell’s MTOCs on ZIKV viroplasm organization production. We...
Abstract Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs development function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed Asian C , African M dengue (DENV). In contrast the robust global transcriptome changes induced by DENV, a more selective larger impact on expression genes involved in DNA replication repair. While overall profiles are similar, but not induces...
Abstract The Zika virus (ZIKV) and dengue (DENV) flaviviruses exhibit similar replicative processes but have distinct clinical outcomes. A systematic understanding of virus–host protein–protein interaction networks can reveal cellular pathways critical to viral replication disease pathogenesis. Here we employed three independent systems biology approaches toward this goal. First, protein array analysis direct interactions between individual ZIKV/DENV proteins 20,240 human revealed multiple...
Functional foods have shown promise in mitigating skin aging. This study aimed to evaluate the effects of Lactiplantibacillus plantarum TWK10 (LPTWK10) and its spray-dried supernatant powder on ultraviolet B (UVB)-induced photoaging female BALB/c nude mice. Over a 13-week period UVB exposure concurrent administration high doses LPTWK10 or fermentation supernatant, significant improvements were observed, wrinkles notably reduced, transepidermal water loss rate decreased by 68.94–70.77%,...
Abstract Toll-like receptors (TLRs) expressed in hematopoietic cells have emerged as sensors for pathogen-associated molecular patterns (PAMPs) and damage-associated (DAMPs), are critical innate immunity. Meanwhile, TLRs, especially TLR4, also found to be various tumor cells. In hepatocellular carcinoma (HCC), TLR4 marcorphages hepatic stellate has been shown involved promoting tumorigenesis. It reported that hepatocytes with hepatitis B or C virus infection, the risk factor HCC, lead...
Zika virus (ZIKV) and dengue (DENV) are two related flaviviruses that share similar replication process but exhibit distinct clinical outcomes. Systematic understanding of virus‐host cell interaction networks can reveal cellular pathways not only critical for viral also pathogenesis. Here we employed a protein array approach to comprehensively identify host proteins interacted by both ZIKV DENV proteins. The results uncovered multiple conserved complexes engaged viruses, such as proteasome...
Abstract The Zika (ZIKV) and dengue (DENV) flaviviruses exhibit similar replicative processes but distinct clinical outcomes. A systematic understanding of virus-host protein-protein interaction networks can reveal cellular pathways critical to viral replication disease pathogenesis. Here we employed three independent systems biology approaches toward this goal. First, protein array analysis direct interactions between individual ZIKV/DENV proteins 20,240 human revealed multiple conserved...