A5019524203- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Transgenic Plants and Applications
- RNA Interference and Gene Delivery
- Biomedical and Engineering Education
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Health and Medical Research Impacts
- Cancer-related Molecular Pathways
- Microplastics and Plastic Pollution
- Ovarian cancer diagnosis and treatment
- PI3K/AKT/mTOR signaling in cancer
- Innovations in Medical Education
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and biological activity of medicinal plants
- CRISPR and Genetic Engineering
- Tea Polyphenols and Effects
- RNA regulation and disease
- Diabetes and associated disorders
Ningbo University
2016-2025
Fujian Medical University
2023-2024
Shanghai Institute of Technology
2024
Huangshi Central Hospital
2023
Hubei Polytechnic University
2023
Guangzhou University of Chinese Medicine
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2014-2022
Institute of Atmospheric Physics
2022
Chinese Academy of Sciences
2022
Jiujiang University
2015
MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) Twist1-mediated signaling remains largely unknown.RT-qPCR western blotting were conducted to detect expression levels lncRNA JPX Twist1 lung lines tissues. The impact on expression, growth, invasion, apoptosis, vivo tumor growth investigated cells by blotting, rescue experiments, colony formation assay, flow...
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify Skp2–macroH2A1 (mH2A1)–cyclin-dependent kinase 8 (CDK8) axis as a critical pathway these processes, deregulation of this is associated with human breast progression patient survival outcome. We showed that mH2A1 new substrate Skp2 SCF complex whose degradation promotes CDK8 gene protein expression....
MicroRNAs (MiRNAs) have been found to be dysregulated in lung cancer tissues compared their matched paracancerous tissues. However, the roles of miRNAs peripheral blood as potential biomarkers for early diagnosis remain poorly understood. Here we that miR-33a-5p and miR-128-3p were down-regulated cell lines. The expression levels significantly correlated TNM stages. MiR-128-3p was also remarkably related smoking tumor size. relative positively Notably, whole patients or early-stage (TNM...
Abstract Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung progression via Twist1-activated EMT may provide potential therapeutic targets for therapy. Here we found that miR-33a, an intronic miRNA located within sterol regulatory element-binding protein 2 (SREBP-2) gene, is expressed at low levels in metastatic non-small cell (NSCLC) cells inversely correlated with Twist1 expression....
The detection of circulating tumor cells (CTCs) has recently received great attention. To evaluate if miR-421 could be used as a specific marker for CTCs, the level in mononuclear (MNCs) from peripheral blood were determined by reverse transcription-polymerase chain reaction. Transfection inhibitor significantly suppressed growth vivo. MNCs gastric cancer was higher than those healthy controls. area under receiver operating characteristic curve 0.773 ± 0.0736. In conclusion, may biomarker...
Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet precise mechanism lung cancer prevention by green remains unclear. microRNAs (miRs) a class 21-24 nucleotide small non-coding RNAs play critical roles throughout cellular development regulation. Emerging evidence demonstrates that influence expression miRs in human cells inhibit...
As peripheral blood contains fluctuated levels of circulating cell-free mitochondrial DNA (ccf mtDNA), we aimed to evaluate ccf mtDNA as a biomarker for diagnosis and prognosis epithelial ovarian cancer (EOC). In the present study, recruited 165 EOC patients 60 healthy women. Quantitative RT-PCR was applied amplify 79-bp 230-bp fragments 16 s RNA gene in sera these participants. MtDNA integrity defined ratio long short fragments. We observed that mtDNA79 mtDNA230 were significantly increased...
Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of cancer shows high genomic instability, but underlying mechanisms causing this phenotype are still largely unknown. Here, we report that upon DNA damage, SPOP phosphorylated at Ser119 by ATM serine/threonine kinase, which potentiates binding to homeodomain-interacting kinase 2 (HIPK2), resulting a nondegradative ubiquitination HIPK2. This...
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera, as well leaves and roots of other plants. The mechanisms its anticancer effect are largely unknown. present study investigated molecular mechanisms. Crystal violet assay showed that aloe-emodin had long-term anti-proliferation on human gastric cancer MGC-803 SGC-7901 cells. Scratch wound-healing motility assays indicated anti-migration effect. arrested cells at G2/M phase. More importantly, inhibited the expressions protein kinase C...
MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung development. However, interaction between miRNAs genes their regulatory effect on cell cycle remain poorly understood. In this study, we investigated role miR-31-5p hMLH1 gene expression non-small (NSCLC). We found that was inversely correlated with NSCLC lines a direct target miR-31-5p. Knockdown induced arrest at G2/M phase...