A5077684763- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Perovskite Materials and Applications
- RNA modifications and cancer
- Conducting polymers and applications
- Fatigue and fracture mechanics
- Cancer Immunotherapy and Biomarkers
- Advanced Photocatalysis Techniques
- Effects of Radiation Exposure
- Cancer Cells and Metastasis
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- CAR-T cell therapy research
- Ureteral procedures and complications
- Immune Cell Function and Interaction
- Lipid metabolism and disorders
- Pelvic floor disorders treatments
- Chalcogenide Semiconductor Thin Films
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- CO2 Reduction Techniques and Catalysts
- Lung Cancer Treatments and Mutations
First Affiliated Hospital of Wannan Medical College
2010-2025
Southern Medical University
2025
Dongguan People’s Hospital
2025
Wannan Medical College
2010-2025
Tianjin Normal University
2023-2024
Jilin University
2016-2021
Health Commission of Jilin Province
2021
The Affiliated Hospital to Changchun University of Chinese Medicine
2018
Stomatology Hospital
2018
Ningbo University
2011-2014
Lymphatic metastasis is recognized as the leading manner of in bladder cancer (BLCa), but hematogenous accounts for a majority cancer-associated deaths. The past two decades have witnessed tremendous attention long non-coding RNAs (lncRNAs), which are new hope development targeted drug therapy metastatic cancers; however, underlying mechanism lncRNAs involved BLCa remains to be elucidated. Here, we identified BLCa-associated transcript 3 (BLACAT3), lncRNA, was aberrantly upregulated and...
Background Cervical cancer is one of the most common cancers in women worldwide. Malignant tumors develop resistance mechanisms and are less sensitive to or do not respond irradiation. With development high-throughput sequencing technologies, circular RNA (circRNA) has been identified an increasing number diseases, especially cancers. It reported that circRNA can compete with microRNAs (miRNAs) change stability translation target RNAs, thus regulating gene expression at transcriptional...
The electron transport layer (ETL) plays an important role in determining the conversion efficiency and stability of perovskite solar cells (PSCs). Here, TiO2 thin film was prepared by irradiating diisopropoxy diacetylacetone titanium precursor with 172 nm vacuum ultraviolet (VUV) at a low temperature. has higher mobility conductivity. As it is used as ETL for MAPbI3 PSCs, its band structure better matched perovskite, same time, due to good interface contact, more uniform crystals are...
Blockage of the interaction between programmed death receptor-1 (PD-1) and ligand-1 (PD-L1) can restore T-cell activity enhance antitumor immunity. PD-1/PD-L1 pathway inhibitors have promising applications in treatment advanced prostate cancer (PCa). We successfully developed a peptides-functionalized gold nanoconstruct (P-AuNS) consisted PD-L1-binding peptide (PD-L1pep, P) nanostar (AuNS), which could bind to cell-surface PD-L1 specifically deliver into PCa cells with high efficiency. In...
Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet precise mechanism lung cancer prevention by green remains unclear. microRNAs (miRs) a class 21-24 nucleotide small non-coding RNAs play critical roles throughout cellular development regulation. Emerging evidence demonstrates that influence expression miRs in human cells inhibit...
Recent studies have suggested that miR-30e-5p is dysregulated in several human carcinomas; however, the mechanism of bladder cancer (BCa) remains unknown. Here, we confirmed expression was decreased BCa specimens and cell lines by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Upregulation proliferation migration T24 UM-UC-3 cells. Metadherin (MTDH) a potential target for through bioinformatics analysis. Dual-luciferase assays were conducted to validate interaction...
BACKGROUND This study aimed to evaluate the risk factors associated with development of urolithiasis in a population Southern China. MATERIAL AND METHODS A questionnaire-based was conducted between March 2017 April 2018 that included 1,519 patients China and questions on patient demographics, diet, lifestyle. Patients were divided into group who had urinary calculi control group. RESULTS There 829 (54.6%) 690 (45.4%) Using chi-squared (χ²) test, 13 variables found be significantly...
High-quality amorphous TiO 2 films were prepared using vacuum ultraviolet light at room temperature and combined with SnO to form a composite ETL. The ETL-based PSC device achieved champion PCE of 24.59% showed improved stability.
MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung development. However, interaction between miRNAs genes their regulatory effect on cell cycle remain poorly understood. In this study, we investigated role miR-31-5p hMLH1 gene expression non-small (NSCLC). We found that was inversely correlated with NSCLC lines a direct target miR-31-5p. Knockdown induced arrest at G2/M phase...
Introduction: Bladder cancer is a lethal human malignancy. Currently, treatment for bladder limited. The anti-tumor effects of leflunomide have attracted much more concern in multiple cancers. Materials and Methods: This study evaluated the on cell viability, colony formation, apoptosis, cycle two carcinoma lines, 5637 T24. Meanwhile, underlying mechanism including PI3K/Akt signaling pathway autophagy modulation was also identified. Results: Leflunomide markedly inhibited growth both lines...
Radiation has been shown to promote the epithelial-mesenchymal transition (EMT) in tumor cells, and TGF-β/Smad PI3K-Akt signaling pathways play an important role EMT. In this study, we investigated effects of neuropilin-1 (NRP1) on radiation-induced non-classical Smad lung cancer as well NRP1 invasion migration.Changes expression levels EMT markers (β-catenin, N-cadherin, vimentin) related transcription factors (Twist ZEB1) stably transfected cells were detected by Western blotting qPCR,...
Wide-bandgap (WBG) inverted perovskite solar cells (PSCs) are used as the top cell for tandem cells, which is an effective way to outperform Shockley-Queisser limit. However, low efficiency and poor phase stability still seriously restrict application of WBG PSCs. Here, surface film was passivated by synthesized 1,2,4-tris(3-thienyl)benzene (THB). The THB size well matches with halogen ion vacancy on surface, S atom in can strongly interact Pb2+ greatest extent, effectively passivates...
Radiotherapy is commonly used to treat lung cancer but may not kill all cells, which be attributed the radiotherapy resistance that often occurs in non‑small cell (NSCLC). At present, molecular mechanism of radio‑resistance remains unclear. Neuropilin 1 (NRP1), a co‑receptor for vascular endothelial growth factor (VEGF), was demonstrated associated with NSCLC cells via VEGF‑phosphoinositide 3‑kinase‑nuclear factor‑κB pathway our previous study. It hypothesized certain microRNAs (miRs) serve...
Abstract Background The roles of lncRNA PLAC2 in bladder cancer (BC) were explored. Methods expression two types tissue BC patients was detected by RT-qPCR and the data compared paired t test. 56 staged according to AJCC criteria, 12, 15, 15 14 cases classified into stage I-IV, respectively. TGF-β1 miR-663 tissues also experiments. Results Our showed that levels significantly lower than non-cancer tissues. not affect clinical stages low predicted survival rate. positively correlated with...
Ewing sarcoma (ES) or primitive neuroectodermal tumors (PNET) represents a spectrum of poorly differentiated and aggressive malignancies. It rarely arises from the kidney accounts for less than 1% renal mass. Given uncharacteristic clinical symptoms imaging features, (RES) is often diagnosed by postoperative pathology.Herein, we depicted case RES, which was administrated in our institution chief complaints intermittent left plank pain palpable abdominal We demonstrated behavior this...
Al-doped ZnO (AZO) nanostructure-based compact thin films were successfully prepared via the irradiation of precursor containing zinc nitrate and aluminum under vacuum ultraviolet (VUV) radiation at 172 nm. The VUV can generate hydroxyl free radicals to make up for oxygen defects on as-prepared AZO films. Meanwhile, photoactivation effect triggered by desorb amorphous species adsorbed surface, thus significantly reducing number surface defects. By changing ratio nitrate, doped amount Al be...