A5017456223- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Nutrition and Health in Aging
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- RNA Research and Splicing
- Gallbladder and Bile Duct Disorders
- Heavy Metal Exposure and Toxicity
- Dialysis and Renal Disease Management
- Ferroptosis and cancer prognosis
- Pelvic floor disorders treatments
- RNA Interference and Gene Delivery
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Shanghai Tenth People's Hospital
2021-2024
Tongji University
2015-2024
Zhejiang University
2012-2024
Stomatology Hospital
2013-2024
Nanjing Medical University
2009-2024
Central Hospital of Putuo District
2022-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023-2024
University of Electronic Science and Technology of China
2023-2024
Health Affairs
2024
Shanghai Medical College of Fudan University
2022-2023
Tumor-promoting niche after incomplete surgery resection (SR) can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment (TME). Herein, elevated neutrophil extracellular traps (NETs) cancer-associated neurotransmitters (CANTs, e.g., catecholamines) are firstly identified as two of the dominant inducements. Further, an injectable fibrin-alginate hydrogel high tissue adhesion has been constructed specifically...
Lymphatic metastasis is recognized as the leading manner of in bladder cancer (BLCa), but hematogenous accounts for a majority cancer-associated deaths. The past two decades have witnessed tremendous attention long non-coding RNAs (lncRNAs), which are new hope development targeted drug therapy metastatic cancers; however, underlying mechanism lncRNAs involved BLCa remains to be elucidated. Here, we identified BLCa-associated transcript 3 (BLACAT3), lncRNA, was aberrantly upregulated and...
Abstract Benign prostatic hyperplasia (BPH) as the leading cause of urination disorder is still a refractory disease, and there have no satisfied drugs or treatment protocols yet. With identifying excessive Zn 2+ , inflammation, oxidative stress etiology aberrant hyperplasia, an injectable sodium alginate (SA) glycyrrhizic acid (GA)‐interconnected hydrogels (SAGA) featuring ‐triggered in situ gelation are developed to load lonidamine for reprogramming prostate microenvironment treating BPH....
To investigate the association between sarcopenia and overactive bladder (OAB) in a United States adult population from 2011 to 2018, whether can predict risk of OAB. We analyzed data 2011–2018 National Health Nutrition Examination Survey crosssectional study(NHANES) 8746 participants, whom 1213 were diagnosed with OAB, we correlations by sex, age, race, education level, marital status, household income-to-poverty ratio, hypertension, diabetes, strenuous work activity, moderate recreational...
This study aims to compare and evaluate the clinical efficacy of laparoscopic capsule-preserving resection (LCPR) partial nephrectomy (LPN) in treatment renal angiomyolipoma (RAML). Multivariate regression analysis was employed identify patient characteristics that are most suited for LCPR. We retrospectively analyzed data 209 patients diagnosed with RAML treated surgically at our hospital between January 2010 December 2023. The were divided into two groups: 102 LCPR group 109 LPN group....
The pathogenesis of bladder cancer (BLCa) is still unclear. Long non-coding RNAs (lncRNAs) participate in diverse biological processes across every branch life, especially cancer. Dysregulated lncRNAs BLCa and their significance require further investigations.Herein, a differential expression profile was conducted by microarray data. level lncRNA LINC01451 70 pairs tissue samples different cell lines were analyzed via real-time quantitative PCR. CRISPR-CAS9 technique employed to establish...
Abstract Background Clear cell renal carcinoma (ccRCC) arises from the parenchymal epithelium and is predominant malignant entity of cancer, exhibiting increasing incidence mortality rates over time. SEC14-like 3 (SEC14L3) has emerged as a compelling target for cancer intervention; nevertheless, precise clinical implications molecular underpinnings SEC14L3 in ccRCC remain elusive. Methods By leveraging data TCGA-ccRCC GEO datasets, we investigated association between expression levels...
Circulating tumor cells (CTCs) are indicative of tumorigenesis, metastasis, and recurrence; however, it is still a great challenge to efficiently analyze the extremely rare CTCs in peripheral blood. Herein, novel nanobiointerface integrating high affinities arrayed silver nanorods (Ag NRs) double-tetrahedral DNA (DTDN) probes by clever strategy proposed for efficient capture, highly sensitive detection, nondestructive release CTCs. Under optimal conditions, DTDN-probe-functionalized Ag NRs...
Abstract The transformation of nonmuscle‐invasive bladder cancer (BLCa) to muscle‐invasive type and distant metastasis are the two major threats patients after surgery. Thus, it is important identify key genes BLCa cell invasion metastasis. Long noncoding RNA (lncRNA) a potential clinical tool for diagnosis treatment. Herein, we verified that lncRNA SNHG3 upregulated in human specimens proportional poor prognosis via combination bioinformatic analyses wet bench experiments. Then, constructed...
We conducted a multi-institutional clinical study to assess the prognostic value of advanced lung cancer inflammatory index (ALI) and modified ALI (mALI) in patients with renal cell carcinoma (RCC).We collected 440 who underwent laparoscopic nephrectomy at three centers from 2014 2019. was defined as body mass (BMI) × serum albumin (ALB)/neutrophil-to-lymphocyte ratio (NLR) mALI L3 muscle ALB/NLR. Kaplan-Meier curves, receiver operating characteristic (ROC) curves Cox survival analysis were...
The aim of this study was to evaluate the prognostic significance systemic inflammatory response index (SIRI) in patients with bladder cancer (BCa) treated radical cystectomy (RC) and develop a survival predictive model through establishing nomogram.
To investigate the relationship between kidney stones and sarcopenia in United States adult population 2011 2018. We conducted a cross-section study based on National Health Nutrition Examination Survey (NHANES) including 39,156 individuals. Sarcopenia was assessed by index. Association verified multiple logistic regression analysis dose-response curves using restricted cubic spline (RCS) regression. Meanwhile, propensity score matching (PSM) performed to exclude effect of confounding...
Sarcopenia as the loss of skeletal muscle mass is related with poor postoperative survival. This work purposed to evaluate prognostic prediction total psoas index (TPI), albumin-globulin score (AGS), and combination TPI AGS (CTA) in bladder cancer (BCa) patients after radical cystectomy.BCa that received cystectomy between 2012 2020 were retrieved from our medical center. The calculation was based on plain computed tomography images. predictive effects TPI, AGS, CTA grade survival BCa...
The aim of the study was to determine whether expression levels specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP).Sixty subjects in early permanent dentition stage and 23 mixed MP were identified. Sixty-eight normal control 24 recruited for comparison. According microarray-based profiling, four miRNAs (let-7i-3p, miR-595, miR-16-2-3p, miR-367-5p) validated.In groups, let-7i-3p significantly over-expressed (P < 0.0005) 0.001) dentitions, miR-595...
Inflammation is widely considered an important hallmark of cancer and associated with poor postoperative survival. The objective this study to assess the significance preoperative C-NLR, a new inflammation-based index that includes C-reactive protein (CRP) neutrophil-to-lymphocyte ratio (NLR), on therapeutic outcomes for bladder (BC) patients after radical cystectomy (RC).BC who underwent RC between 2010 2019 were retrospectively analyzed from our medical center. predictive effect CRP, NLR,...
Excessive alcohol intake is a major risk factor for pancreatitis, sensitizing the exocrine pancreas to stressors by mechanisms that remain obscure. Impaired autophagy drives nonalcoholic but effects of ethanol (EtOH) and alcoholic pancreatitis on are poorly understood. Here, we find reduces autophagosome formation in pancreatic acinar cells, both mouse model induced combination EtOH diet cerulein (a CCK ortholog) EtOH+CCK-treated cells (ex vivo model). Ethanol treatments decreased level...
Abstract Background In a multi‐institutional clinical study, we assessed the prognostic significance of novel indicator preoperative peripheral blood immune (PBIS) scores that combined ratios lymphocyte, monocyte, and neutrophil renal cell carcinoma (RCC) patients undergoing laparoscopic nephrectomy. Methods Between January 2014 December 2019, 438 with RCC were retrospectively analyzed in three centers. We used X‐tile software to obtain optimum cut‐off values for neutrophils, monocytes,...
Patients diagnosed with papillary renal cell carcinoma (pRCC) exhibit a high rate of clinical metastasis; however, the underlying molecular mechanism is unclear. In this study, KH-type splicing regulatory protein (KHSRP) participated in pRCC progression and was associated metastasis. It positively correlated hallmark epithelial-mesenchymal transition. KHSRP inhibition effectively alleviated cellular function migration invasion. Additionally, knockdown inhibited proliferative ability cells. A...
Clear cell renal carcinoma (ccRCC) is one of the most common malignant kidney tumors with a poor prognosis. Accumulating evidence proves that zinc finger protein 268 (ZNF268) associated tumor progression, but detailed regulatory functions ZNF268 in ccRCC require further exploration. Thus, here we aim to characterize role ccRCC. The clinical significance was evaluated using Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Subsequently, tumor-infiltrating immune...