A5070315504- Renin-Angiotensin System Studies
- Nanoparticles: synthesis and applications
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Receptor Mechanisms and Signaling
- Pediatric Hepatobiliary Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Hormonal Regulation and Hypertension
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Air Quality and Health Impacts
- Cell Adhesion Molecules Research
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- Pancreatic function and diabetes
- Gastroesophageal reflux and treatments
- Cardiac Ischemia and Reperfusion
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Mesoporous Materials and Catalysis
- Skin and Cellular Biology Research
University of Szeged
2015-2024
University of California System
2024
University of California, Los Angeles
2024
MRC Human Immunology Unit
2013
Aarhus University
2007
Loss of function the tumour suppressor p53 observed frequently in human cancers challenges drug-induced apoptotic elimination cancer cells from body. This phenomenon is a major concern and provides much impetus for current attempts to develop new generation anticancer drugs capable provoking apoptosis p53-independent manner. Since silver nanoparticles (AgNPs) possess unique cytotoxic features, we examined, whether their activity could be exploited kill suppressor-deficient cells. Therefore,...
Development of multidrug resistance (MDR) is a major burden successful chemotherapy, therefore, novel approaches to defeat MDR are imperative. Although the remarkable anti-cancer propensity silver nanoparticles (AgNP) has been demonstrated and their potential application in cancer proposed, nanoparticle size-dependent cellular events directing P-glycoprotein (Pgp) expression activity have never addressed. Hence, present study we examined AgNP features resistant breast cells.In this report...
Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth metastatic dissemination, therapeutic strategies targeting stroma are still not common in clinical practice. Metal-based nanomaterials have been shown exert excellent cytotoxic anti-cancerous activities, however, their effects on reactive never investigated details. Thus, using feasible vitro vivo systems model microenvironment, we...
Cell wall-associated defence against zinc oxide nanoparticles (ZnO NPs) as well nitro-oxidative signalling and its consequences in plants are poorly examined. Therefore, this study compares the effect of chemically synthetized ZnO NPs (~45 nm, 25 or 100 mg/L) on Brassica napus juncea seedlings. The effects root biomass viability suggest that B. is more tolerant to NP exposure relative juncea. This may be due lack Zn ion accumulation roots, which related increase amount lignin, suberin,...
Background: Several epidemiological and laboratory studies have evidenced the fact that atmospheric particulate matter (PM) increases risk of respiratory morbidity.It is well known smallest fraction PM (PM1particulate having a diameter below 1 μm) penetrates deepest into airways.The ratio different size fractions in highly variable, but industrial areas PM1 can be significant.Despite these facts, health effects been poorly investigated air quality standards are based on PM10 PM2.5 (PM...
Radiosensitizing agents are capable of augmenting the damage ionizing radiation preferentially on cancer cells, thereby increasing potency and specificity radiotherapy. Metal-based nanoparticles have recently gathered ground in radio-enhancement applications, owing to their exceptional competence amplifying cell-killing effects irradiation. Our aim was examine radiosensitizing performance gold (AuNPs) chromatin-modifying histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)...
We have previously shown that chenodeoxycholic acid (CDCA) strongly inhibits pancreatic ductal HCO 3 − secretion through the destruction of mitochondrial function, which may significance in pathomechanism acute pancreatitis (AP). Ursodeoxycholic (UDCA) is known to protect mitochondria against hydrophobic bile acids and has an ameliorating effect on cell death. Therefore, our aim was investigate UDCA pretreatment CDCA-induced injury. Guinea pig intrainterlobular ducts were isolated by...
Non-spherical titanium dioxide (TiO2) nanoparticles have been increasingly applied in various biomedical and technological fields. Their toxicological characterization is, however, less complete than that of roundish nanoparticles.Anatase form TiO2 nanorods, ca. 15x65 nm size, were to cultured astrocytes vitro the airways young adult Wistar rats vivo 5, 10, 8 mg/kg BW dose for altogether 28 days. Presence nanorods cellular damage was investigated rat lungs kidneys. Functional nervous system...
The cation-exchange reaction between sodium montmorillonite and tetradecyltrimethylammonium bromide serving as a stabilizing agent in palladium hydrosol led to the formation of alkylammonium with simultaneous immobilization nanoparticles organoclay host; Pd-organoclay proved be catalytically active olefin hydrogenation liquid phase.
The modification of photonic nanoarchitectures occurring in butterfly wing scales with different nanostructures was investigated experimentally and by modeling. Single crystalline, polycrystalline, simple thin film, pepper-pot-type the butterflies were investigated. By atomic layer deposition (ALD) (additive) color all red shifted plasma etching (subtractive) blue a controllable way. Langmuir-Blodgett multilayers silica nanospheres used as physical models. ALD produced shifts similar to...
Abstract We examined local and systemic antiinflammatory consequences of ischemic preconditioning (IPC) in a rat model limb ischemia‐reperfusion (I‐R) by characterizing the leukocyte‐endothelial interactions periosteum expression adhesion molecules playing role leukocyte‐mediated inflammatory processes. IPC induction (2 cycles 10 min complete ischemia reperfusion) was followed 60 ischemia/180 reperfusion or sham‐operation. Data were compared with those on animals subjected to I‐R Neutrophil...