A5088378652- Hungarian Social, Economic and Educational Studies
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Bone health and treatments
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Organophosphorus compounds synthesis
- Prenatal Screening and Diagnostics
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Carbon Nanotubes in Composites
- Immune Response and Inflammation
- Hemodynamic Monitoring and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Urinary Bladder and Prostate Research
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Heat shock proteins research
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Molecular Spectroscopy and Structure
- Graphene research and applications
University of Szeged
2016-2025
Gottsegen National Cardiovascular Center
2024-2025
University of Pecs
2010-2024
Ghent University
2024
Faculty (United Kingdom)
2021
La Jolla Bioengineering Institute
2020
University of California, San Diego
2020
University of Debrecen
1967-2020
Government of Hungary
2020
Lungenklinik Hemer
2016
Molecular chaperones of the Hsp70 class bind unfolded polypeptide chains and are thought to be involved in cellular folding pathway many proteins. DnaK, protein Escherichia coli, is regulated by chaperone DnaJ cofactor GrpE. To gain a biologically relevant understanding mechanism action, we have analyzed model reaction which DnaJ, GrpE mediate denatured firefly luciferase. The binding release substrate for involves following ATP hydrolysis-dependent cycle: (i) luciferase binds initially...
The challenge on carbon nanotubes is still the subject of many research groups. While in first years focus was new synthesis methods, sources and support materials, recently, application possibilities are principal arguments studies. three main methods discussed this review arc discharge, laser ablation chemical vapour deposition (CVD) with a special regard to latter one. In early stage nanotube production two were utilized mainly for SWNTs while third one produced MWNTs. principle CVD...
1. Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of nitric oxide with superoxide anion, and hydroxyl radical, in iron-catalysed Fenton reaction, are important mediators reperfusion injury. In vitro studies, DNA single strand breakage, triggered peroxynitrite or activates nuclear enzyme poly (ADP-ribose) synthetase (PARS), consequent effects. Using 3-aminobenzamide, an inhibitor PARS, we investigated role PARS pathogenesis splanchnic artery occlusion shock. 2. Splanchnic...
The nature of the chemical bond in main group diborane(4) compounds X2B-BX2 (X = H,F,Cl,Br,I) and Fischer- Schrock-type transition metal carbene carbyne complexes heavier homologues (CO)5W-CH2, (CO)5W-E(OH)2, Cl4W-EH2, Cl(CO)4W-EH Cl3W-EH (E C,Si,Ge,Sn,Pb) have been investigated with an energy decomposition analysis (EDA). results give a deep insight into interactions. EDA can be used as bridge between heuristic models experimental chemists which proven useful ordering schemes for...
Background/Aims: Electrophilic methyl groups bound to positively charged nitrogen moieties may act as electron acceptors, and this mechanism could lead the generation of methane from choline. The aims were characterize methanogenic potential phosphatidylcholine metabolites, define in vivo relevance pathway hypoxia-induced cellular responses. Methods: postulated reaction was investigated (1) model chemical experiments, (2) rat mitochondrial subfractions (3) bovine endothelial cell cultures...
Peroxynitrite-mediated DNA strand breaks trigger poly (ADP-ribose) synthetase (PARS) activation, resulting in intracellular energetic failure and organ dysfunction. We investigated the role of PARS activation on inflammatory functional response intestine to mesenteric ischemia-reperfusion injury. Anesthetized rats exposed 15 min occlusion superior artery showed an increased mucosal activity (ex vivo incorporation radiolabelled NAD+ gut scrapings) as soon 10 after reperfusion. During first 30...
Previous studies demonstrated methane generation in aerobic cells. Our aims were to investigate the methanogenic features of sodium azide (NaN(3))-induced chemical hypoxia whole animal and study effects l-α-glycerylphosphorylcholine (GPC) on endogenous production inflammatory events as indicators a NaN(3)-elicited mitochondrial dysfunction. Group 1 Sprague-Dawley rats served sham-operated control; group 2, animals treated with NaN(3) (14 mg·kg(-1)·day(-1) sc) for 8 days. In 3, chronic...
Objectives: A common potentially fatal disease of the pancreas is acute pancreatitis, for which there no treatment. Most studies this disorder focus on damage to acinar cells since they are assumed be primary target multiple stressors affecting pancreas. However, increasing evidence suggests that ducts may also have a crucial role in induction disease. To test hypothesis, we sought determine specific duct pancreatitis using well-established models and mice with deletion Na+/H+ exchanger...
Mitochondrial-derived reactive oxygen species have been deemed an important contributor in sepsis pathogenesis. We investigated whether two mitochondria-targeted antioxidants (mtAOX; SkQ1 and MitoTEMPO) improved long-term outcome, lessened inflammation, organ homeostasis polymicrobial murine sepsis. 3-month-old female CD-1 mice (n = 90) underwent cecal ligation puncture (CLP) received (5 nmol/kg), MitoTEMPO (50 or vehicle 5 times post-CLP. Separately, 52 SkQ1-treated CLP were sacrificed at...
Background and Aims The systemic host response in sepsis is frequently accompanied by central nervous system (CNS) dysfunction. Evidence suggests that excessive formation of neutrophil extracellular traps (NETs) can increase the permeability blood–brain barrier (BBB) evolving mitochondrial damage may contribute to pathogenesis sepsis-associated encephalopathy. Kynurenic acid (KYNA), a metabolite tryptophan catabolism, exerts pleiotropic cell-protective effects under pro-inflammatory...
In this Account, the intramolecular hydrogen bonding (HB) properties of various proton acceptor groups (BX(n): C=N, NO(2), C=O, P=O, F, CF(3)) with OH and NH(2) (AH) in benzene derivatives are assessed on basis gas electron diffraction, spectroscopic, quantum chemical results. The most important HB energy, characteristic geometrical changes interacting (lengthening A-H B-X, shortening C-A C-B bonds) ring, vibrational AH groups. These particular interaction (in BX(n) pair single multiple...
We have shown that phosphatidylcholine (PC) metabolites may a function in counteracting the production of reactive oxygen species (ROS), and this mechanism can lead to generation methane from choline. The aims were establish whether dietary administration PC protect reperfused small bowel mucosa by its acting as an anti-inflammatory agent investigate possibility association with vivo generation. Group 1 (n = 5) anesthetized dogs served sham-operated controls, whereas groups 2 6) 3 6),...
Aerobic methane generation was demonstrated earlier in plants and eukaryotes under various stress conditions. Our aims were to develop a real-time noninvasive detection system for monitoring the production of small animals humans with our without exposure treatments. A near-infrared diode laser technique employed photoacoustic spectroscopy monitor methane-containing atmosphere online. The whole-body anesthetized mice rats determined baseline conditions following reduction intestinal...
The potential energy surface (PES) of the dimers formaldehyde derivatives CH(O)Y (Y = H, CH3, F, Cl, Br, I) has been investigated by means quantum chemical calculations at MP2/6-311++G** level. Several minima have found on PES characterized various combinations C−H···X (X O, halogen) contacts. computed dimerization energies revealed importance dispersion forces in formation [CH(O)Y]2 dimers, while only a lesser role intermolecular H···X interactions. most characteristic geometrical...
ABSTRACT Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate associated with PERV transmission human patients by pig tissue xenotransplantation or study potential pathogenesis infection. In previous work we isolated two genes encoding functional receptors and proved that introduction these into mouse fibroblasts allowed normally nonpermissive cells become productively infected (T. A....
This paper describes a photoacoustic spectroscopy-based detector of hydrogen sulfide (H2S) in biogas, natural gas and oil process technology. The instrument is capable measuring H2S concentrations over four orders magnitude (from few ppm level up to several per cent) changing mixtures. Problems caused by harsh industrial circumstances, contamination widely varying composition gases can be overcome optimizing wavelength modulation, resonance frequency tracking an easy-to-use method enabling...