A5080224658- Renal Diseases and Glomerulopathies
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Renal cell carcinoma treatment
- Renal and related cancers
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Urinary Tract Infections Management
- Chronic Kidney Disease and Diabetes
- Heat shock proteins research
- Nephrotoxicity and Medicinal Plants
- Trace Elements in Health
- Diabetes and associated disorders
- Metabolism and Genetic Disorders
- Bladder and Urothelial Cancer Treatments
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
University of Szeged
2015-2025
University of Pecs
2022
SeqOmics Biotechnology (Hungary)
2022
Semmelweis University
2022
State Key Laboratory of Kidney Diseases
2013
University of Bari Aldo Moro
2013
Hôpital Edouard Herriot
2013
Ospedale Bassini
2013
Ruijin Hospital
2013
Shanghai Jiao Tong University
2013
Transcranial electric stimulation is a non-invasive tool that can influence brain activity; however, the parameters necessary to affect local circuits in vivo remain be explored. Here, we report rodents and human cadaver brains, ~75% of scalp-applied currents are attenuated by soft tissue skull. Using intracellular extracellular recordings rats, find at least 1 mV/mm voltage gradient neuronal spiking subthreshold currents. We designed an 'intersectional short pulse' method inject...
Animal models are ideal to study the pathomechanism and therapy of acute pancreatitis (AP). The use L-arginine-induced AP model is nowadays becoming increasingly popular in mice. However, carefully looking through literature, marked differences disease severity could be observed. In fact, while setting up L-arginine (2×4 g/kg i.p.)-induced BALB/c mice, we found a relatively low rate (around 15%) pancreatic necrosis, whereas others have detected much higher rates (up 55%). We suspected that...
This study examined whether administration of L-carnitine ameliorates gentamicin-induced renal injury in rats.Male Sprague-Dawley rats were assigned to one seven treatment groups: group A (control) given normal saline injections daily for 8 consecutive days; B, C and D gentamicin injections, 50 mg/kg body weight/day E, F G 80 mg/kg/day days. Starting 4 days before these all groups additional 12 days, (groups A, B E) or at 40 F) 200 G). Histological scoring cortical pathology was performed...
Objective: Intraperitoneal administration of large doses l-arginine is known to induce severe acute pancreatitis in rats. We therefore set out determine whether metabolites (l-ornithine, l-citrulline, and nitric oxide) cause pancreatitis. Design: The authors conducted an vivo animal study. Setting: This study was at a university research laboratory. Subjects: Study subjects were male Wistar Interventions: Dose–response time course changes laboratory histologic parameters determined after...
Objectives: A common potentially fatal disease of the pancreas is acute pancreatitis, for which there no treatment. Most studies this disorder focus on damage to acinar cells since they are assumed be primary target multiple stressors affecting pancreas. However, increasing evidence suggests that ducts may also have a crucial role in induction disease. To test hypothesis, we sought determine specific duct pancreatitis using well-established models and mice with deletion Na+/H+ exchanger...
The ultrastructural features of peritubular capillary (PC) damage was studied in 12 kidney allografts with acute humoral rejection (AHR). AHR manifested diffuse linear PC staining for C4d, and histology consistent Banff grade III 7 recipients II 5. Allografts tubular necrosis served as controls. First biopsies (post-transplantation day 16.2 +/- 2.2): intra-capillary exudate comprised monocytes (59%), polymorphonuclears (14%), lymphocytes (12%) not otherwise specified mononuclears (15%)....
Aims: Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another acid, L-lysine, was also shown to cause acinar cell injury. The aim study get insight into through which L-lysine damages rat exocrine pancreas, particular characterize kinetics L-lysine-induced mitochondrial injury, as well pathologic responses (including alteration antioxidant...
The clinicopathological and molecular features of synchronous parathyroid carcinoma (PC) thyroid in a male patient are presented. At 11, he received mantle field radiotherapy for Hodgkin lymphoma. He had 26-year adulthood history recurrent nephrolithiasis treated five times with lithotripsy. 52, was referred to our clinic hypercalcemia. Primary hyperparathyroidism diagnosed (calcium: 3.46 mmol/L, parathormone: 150 pmol/L, preserved renal function, nephrolithiasis, osteoporosis). Neck...
Fibronectin glomerulopathy (FG) is caused by fibronectin 1 (FN1) gene mutations. A renal biopsy was performed on a 4-year-old girl with incidentally discovered proteinuria (150 mg/dL); her family history of disease negative. Markedly enlarged glomeruli (mean glomerular diameter: 196 μm; age-matched controls: 140 μm), α-SMA-positive and Ki-67-positive mesangial cell proliferation (glomerular index 1.76), the mild expansion areas, no immune or electron-dense deposits, normal basement membrane,...
Xp11.2 translocation carcinoma is a distinct subtype of renal cell characterized by translocations involving the TFE3 gene. Our study included morphological, immunohistochemical and clinicopathological examination 28 RCCs. The immunophenotype has been assessed using CA9, CK7, CD10, AMACR, MelanA, HMB45, Cathepsin K immunostainings. diagnosis was confirmed break-apart FISH in 25 cases. ages 13 male 15 female patients, without underlying disease or having undergone chemotherapy ranged from 8...
Objectives: Intraperitoneal (IP) injection of 3.5 g/kg L-arginine (known to induce acute pancreatitis) in rats will result much greater increases serum ornithine versus citrulline concentration (Crit Care Med. 2008;36:2117-2127). These data indicate a major role arginase the catabolism L-arginine. Therefore, we tested effects irreversible inhibitor (+)-S-2-amino-6-iodoacetamidohexanoic acid (AIHA) on L-arginine-induced pancreatitis. Methods: The inhibitory effect AIHA activity was rat liver...