A5018003191- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Systemic Lupus Erythematosus Research
- Inflammation biomarkers and pathways
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Chemokine receptors and signaling
- Immune cells in cancer
- Blood Coagulation and Thrombosis Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Whipple's Disease and Interleukins
- Aldose Reductase and Taurine
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Hematological disorders and diagnostics
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
Affiliated Hospital of Youjiang Medical University for Nationalities
2014-2025
First Affiliated Hospital of Jinan University
2024-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2023
Sun Yat-sen University
2023
University of California, Los Angeles
2023
Fourth Affiliated Hospital of Guangxi Medical University
2016
Youjiang Medical College for Nationalities
2013
Jinan University
2013
Zhujiang Hospital
2012
Southern Medical University
2012
Acute respiratory distress syndrome (ARDS) is characterized by inflammatory injury to the alveolar and capillary barriers that results in impaired gas exchange severe acute failure. Nuclear orphan receptor Nur77 has emerged as a regulator of gene expression inflammation, its role pathogenesis ARDS not clear. The objective this study investigate potential underlying mechanism regulation endothelin-1 (ET-1) lipopolysaccharide (LPS)-induced A549 cells an rat model. We demonstrate LPS induced...
Copper, an indispensable trace element for the human body, serves not only as a crucial auxiliary factor in redox reactions within organism but also significant constituent of numerous key metabolic enzymes.The COMMD family plays vital role regulating copper at both cellular and systemic levels, particularly realm tumor research, area notably deficient gastric cancer investigations.With advancement precision medical techniques, individualized precise screening treatment have become paramount...
Pancreatic cancer, a highly malignant tumor of the digestive system, is characterized by microenvironment with high degree immunosuppression. This immunosuppressive property poses significant challenges, as it hampers effective infiltration immune cells and impairs their ability to exert cytotoxic effects. The metabolic process taurine has emerged crucial factor in modulating functions activities cells. Intervening metabolism holds potential reshape microenvironment, thereby enhancing...
Abstract Involvement of long non-coding RNAs (lncRNAs) in hepatocarcinogenesis has been largely documented. Mitochondrial dynamics is identified to impact survival and metastasis tumors including hepatocellular carcinoma (HCC), but the underlying mechanism remains poorly understood. This study planned explore regulation lncRNA LL22NC03-N14H11.1 on HCC progression mitochondrial fission. Dysregulated lncRNAs are through circlncRNAnet GEPIA bioinformatics tools. Biological function was detected...
Sepsis is now the leading cause of death in non-cardiovascular intensive care unit (ICU). Recent research suggests that sepsis likely to be due an interaction between genetic and environmental factors. Genetic mutations toll-like receptor 4 (TLR4) cluster differentiation 14 (CD14) genes are involved immune (or) inflammatory response. These may contribute susceptibility patients. This study was designed evaluate whether TLR4 CD14 gene polymorphisms associated with sepsis. The single...
This study investigated the relationship of Fas and ligand (FasL) expression apoptosis lymphocytes in relation to pathogenic immune response infectious complications observed experimental severe acute pancreatitis mice. Forty male Balb/c mice were randomly divided into control, mild (MAP), (SAP) groups. Overexpression Fas/FasL messenger ribonucleic acid (mRNA) protein was spleen-derived SAP (p < 0.01). Apoptosis these resulted a depletion circulating this group 0.05). A further significant...
Fractalkine (FKN) is involved in the occurrence and development of human lupus nephritis. It known to be upregulated by lipopolysaccharide (LPS) as a stimulus vivo. MRL/lpr mice have been used an vivo model study Methylprednisolone (MP) widely clinical treatment progressive glomerular diseases such The aim this explore mechanism LPS induced FKN expression determine whether other molecular mechanisms contribute signaling pathway MP action mice.Forty-eight female at 12 weeks age were randomly...
Background . LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated relationship between LPS-induced A549 cells rat lung tissue an ARDS model. Methods were transfected with or shRNA plasmid DNA pretreated SB203580 SC-514 following LPS treatment. An model was established using without LBPK95A, SB203580, RT-PCR, western blotting, ELISA, immunofluorescence, coimmunoprecipitation, immunohistochemical staining used expression p38 MAPK p65 NF- κ B...
Excessive alcohol intake is a major risk factor for pancreatitis, sensitizing the exocrine pancreas to stressors by mechanisms that remain obscure. Impaired autophagy drives nonalcoholic but effects of ethanol (EtOH) and alcoholic pancreatitis on are poorly understood. Here, we find reduces autophagosome formation in pancreatic acinar cells, both mouse model induced combination EtOH diet cerulein (a CCK ortholog) EtOH+CCK-treated cells (ex vivo model). Ethanol treatments decreased level...
miR-125a-5p's role in various cancers has been recognized, yet its specific function pancreatic cancer (PCa) demands further exploration. This study aimed to reveal the potential of miR-125a-5p PCa.
Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy, with its pathogenesis involving complex interplay of molecular mechanisms, including cell cycle dysregulation, evasion apoptosis, enhanced angiogenesis, and aberrant immune responses. Precision medicine approaches that target specific subtypes through multi-omics integration hold promise for improving patient survival. Among the various players, sphingolipids have emerged as pivotal regulators tumor growth...
Objective To examine the potential relationship of EPCR polymorphisms and risk sepsis in a Chinese population. Methods Snapshot SNP genotyping assays DNA sequencing methods were used to detect gene, rs2069948C/T (2532C/T) rs867186A/G (6936A/G), 64 patients with 113 controls. Soluble (sEPCR) was measured by ELISA. Results There significant differences allele genotype frequencies gene between male female Females carrying rs2069948 C/T or T males rs867186 A associated significantly increased...
Ferroptosis is regarded as a promising cancer therapeutic target. As major bioactive compound from traditional Chinese medicine (TCM) herb Sophora flavescens Aiton, oxymatrine (OMT) can depress inflammatory factors, reduce iron deposition, and suppress the hub gene or protein expression involved in ferroptosis inflammation. Additionally, OMT control collagen deposition liver has effect on cancer. This research investigated action mechanism of process triggered cell death restrained...
Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 vitro. A549 cells were pre-treated with S2505 (10 μM), S2871 μM) with/without SB203580 for 60 min following 2 h treatment 10 ng/mL TGF-β1. also transfected positive or negative PPAR-γ plasmids comparison. RT-PCR, ELISA, western blotting confocal laser scanning microscopy (CLSM) used measure relevant expression mRNA, protein,...