A5101745928- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- Membrane Separation Technologies
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Advanced Battery Materials and Technologies
- Thermochemical Biomass Conversion Processes
- Circular RNAs in diseases
- Polymer Surface Interaction Studies
- MicroRNA in disease regulation
- Iron and Steelmaking Processes
- Photoreceptor and optogenetics research
- Cancer-related molecular mechanisms research
- Supercapacitor Materials and Fabrication
- Membrane-based Ion Separation Techniques
- Gear and Bearing Dynamics Analysis
- Cultural, Linguistic, Economic Studies
- Electrocatalysts for Energy Conversion
- Abdominal Trauma and Injuries
- Advanced oxidation water treatment
- Corporate Identity and Reputation
- Risk Management in Financial Firms
Soochow University
2014-2025
West China Hospital of Sichuan University
2024
Yangzhou University
2024
Sichuan University
2014-2024
Institute of Molecular Functional Materials
2024
Nanjing Medical University
2013-2023
Xuzhou Medical College
2023
Suzhou Municipal Hospital
2023
Weatherford College
2023
Zhongda Hospital Southeast University
2023
The key property of protein–nanoparticle conjugates is the bioactivity protein. ability to accurately modulate activity protein on nanoparticles at interfaces important in many applications. In work reported here, modulation protein–gold nanoparticle (AuNP) by specifically orienting and varying surface density was investigated. Different orientations were achieved introducing cysteine (Cys) residues specific sites for binding gold. We chose Escherichia coli inorganic pyrophosphatase (PPase)...
Rechargeable zinc batteries (RZBs) are hindered by two primary challenges: instability of Zn anode and deterioration the cathode structure in traditional aqueous electrolytes, largely attributable to decomposition active H2O. Here, we design synthesize a non‐flammable water‐in‐dimethyl sulfoxide electrolyte address these issues. X‐ray absorption spectroscopy, situ techniques computational simulations demonstrate that activity H2O this is extremely compressed, which not only suppresses side...
Visible light induced fast and controllable RAFT polymerization from protein as a novel method for preparing protein–polymer conjugates at ambient temperature.
Anticoagulant surface modification of blood-contacting materials has been shown to be effective in preventing thrombosis and reducing the dose anticoagulant drugs that patients take. However, commercially available coatings, is, both bioinert bioactive are typically based on a single anticoagulation strategy. This puts function coating at risk failure during long-term use. Considering several pathways human coagulation system, synergy multiple theories may provide separate, targeted effects...
Porous magnetic iron oxide nanoparticles are developed as a photoporation nanoplatform for macromolecular delivery.
Stem cell therapy shows great potential in the treatment of neurodegenerative diseases, which efficient neural differentiation stem cells is still challenging.
P2-type Mn-based layered oxides are among the most prevalent cathodes for sodium-ion batteries (SIBs) owing to their low cost, resource abundance, and high theoretical specific capacity. However, they usually suffer from Jahn-Teller (J-T) distortion high-spin Mn3+ poor cycling stability, resulting in rapid degradation of structural electrochemical properties. Herein, a stable oxide is realized through local construction strategy by introducing high-valence Ru4+ overcome these issues. It has...
Abstract There is increasing evidence that exosome-mediated transmission of microRNAs helps to connect tumor-associated macrophages and cancer cells, including lung adenocarcinoma (LUAD) cells. The objective this study identify the role miR-3153 in LUAD progression M2 macrophage polarization explore its regulatory mechanism. relevant molecular mechanisms were analyzed validated through mechanistic assays. In vitro functional assays followed by vivo experiments implemented evaluate exosomes...
To clarify the role of LINC00702 in progression ovarian cancer (OC) and potential mechanism.Expression level OC tissues matched normal was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). cell lines determined as well. The influences on cellular behaviors A2780 HEY cells were evaluated. subcellular distribution examined. Through RNA immunoprecipitation (RIP) Chromatin (ChIP) assay, interaction among LINC00702, EZH2, KLF2 verified. rescue experiments conducted to...
A polyacrylamide-based nanogel sensor was constructed for spectral and visual colorimetric fluorescence measurement of ionizing radiation doses. The showed a good linear reproducible response in the dose range 0-20 Gy with low errors, temperature stability durability. used to detect X-ray-irradiated tumor cell
The intracellular delivery of exogenous macromolecules is great interest for both fundamental biological research and clinical applications. Although traditional systems based on either carrier mediation or membrane disruption have some advantages; however, they are generally limited with respect to efficiency cytotoxicity. Herein, a collaborative platform excellent comprehensive performance developed using polyethylenimine low molecular weight (LPEI) as gene in conjunction gold nanoparticle...
Regulating cell behavior and fate are of great significance for basic biological research therapy. Carbohydrates, as the key biomacromolecules, play a crucial role in regulating behavior. Herein, "modular" glycopolymers were synthesized by reversible addition–fragmentation chain transfer polymerization. These contain sugar units (glucose), anchoring (cholesterol), "guest" (adamantane) host–guest interaction, fluorescent labeling (fluorescein). It was demonstrated that these can insert into...
P2-type Mn-based layered oxides have emerged as one of the most promising cathode materials for sodium-ion batteries owing to their advantages facile preparation and high theoretical capacity. However, challenges such phase transition irreversible oxygen release during cycling often lead rapid structural distortion formation vacancies, ultimately resulting in capacity decay. Herein, a covalency modulation strategy is adopted address these successfully achieved stable oxide by introducing...
The neural differentiation of embryonic stem cells (ESCs) is great value in the treatment neurodegenerative diseases. On basis two related signaling pathways that direct ESCs, we used gold nanoparticles (GNP) as a means combining chemical and physical cues to trigger neurogenic cells. Neural differentiation-related functional units (glyco sulfonate on glycosaminoglycans, GAG) were anchored GNP surface then transferred cell membrane via GNP-membrane interactions. able activate GAG-related...
The time-varying meshing stiffness (TVMS) is an important element of the gear system. In this paper, TVMS each set a wind turbine gearbox calculated based on principle potential energy method, where wear most likely failure in operation gearbox. Therefore, Archard model brought into it, and theoretically analytical formula considering tooth derived, depth deduced as natural speed keeps changing input torque changing. interrelationship between pressure angle number meshes studied depth, under...