A5101947727- Acute Myeloid Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Advanced Glycation End Products research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- TiO2 Photocatalysis and Solar Cells
- Retinoids in leukemia and cellular processes
- Bacterial biofilms and quorum sensing
- Multiple Myeloma Research and Treatments
- Advanced Biosensing Techniques and Applications
- Connective Tissue Growth Factor Research
- Protein Degradation and Inhibitors
- Biochemical effects in animals
- Neonatal and Maternal Infections
- Natural Compounds in Disease Treatment
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Microbial Metabolism and Applications
- Mesenchymal stem cell research
Xian Central Hospital
2020-2024
Shaanxi University of Chinese Medicine
2024
Changzhi Medical College
2017-2021
First Hospital of Xi'an
2020-2021
Lanzhou University
2018-2020
First Hospital of Lanzhou University
2018-2020
Changzhi Medical College Peace Hospital
2019
University of Benin
2017
Beijing Children’s Hospital
2013-2015
Capital Medical University
2013-2015
This study aims to investigate the clinical features of invasive community-acquired Staphylococcus aureus (CA-SA) infection in Chinese children and analyze its molecular features.Clinical data CA-SA isolates were prospectively collected. Pediatric risk mortality (PRISM) score was used for disease severity measurement. Molecular typing then performed, followed by expression analysis virulence genes.Among 163 cases, 71 (43.6%) methicillin-resistant SA (MRSA) infections 92 (56.4%)...
Summary Increased levels of plasma free amino acids (p FAA s) can disturb the blood glucose in patients with obesity, diabetes mellitus and metabolic syndrome ( MS ) are associated enhanced protein oxidation. Oxidation proteins, especially muscles, promote degradation elevate p s. Gamma‐aminobutyric acid GABA ), a food additive, reduce high‐fat diet HFD )‐induced hyperglycaemia; however, mechanisms remain unclear. The aim this study was to evaluate effects on oxidation s changes. One hundred...
This study aims to investigate the prevalence of a novel cell wall-anchored protein gene, sasX, and obtain information on genetic basis for pathogenic potential MRSA strains isolated from Chinese children. The molecular virulence characteristics clinical were analyzed. Twenty-two sequence types (STs) obtained, with six epidemic clones ST59, ST239, ST1, ST910, ST88, ST338 accounting 35.8, 22, 6.6, 5.3, 4.1% respectively. expression levels hla, psmα, RNAIII higher in ST59 than other STs (p <...
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear. The present study was performed investigate of OP-D STZ-induced DN rat model. showed dysfunction, as evidenced by decreased serum albumin and creatinine clearance, along with increases...
Abstract Introduction To confirm the role of additional chromosomal abnormalities (ACAs) and kinase domain (KD) mutations in progression outcomes Chronic myeloid leukaemia (CML) patients connection between them, we analysed ACAs KD 219 CML admitted to our hospital. Methods Cytogenetic analysis metaphases was performed detect ACAs, BCR‐ABL1 sequenced mutations. Results Twenty‐four (11.0%) had addition or t(9;22)(q34;q11) translocation. The most common abnormality trisomy 8. Twelve different...
Long non-coding RNA psoriasis-susceptibilityrelated gene induced by stress (PRINS) is known to be involved in kidney ischemia reperfusion injury. The aim of the current study was investigate potential role PRINS diabetic nephropathy. relative mRNA expression level and SMAD family member 7 (Smad7) examined patients with diabetes, including without obvious complications (n=43), nephropathy (n=33), retinopathy (n=37), cardiomyopathy (n=29), lung disease (n=38) healthy controls (n=48)....
This study aims to characterize the clinical features of community‐acquired methicillin‐resistant Staphylococcus aureus ( CA ‐ MRSA ) infections in Chinese neonates, as well molecular characteristics and expression key virulence genes isolates. Clinical information 130 cases were analyzed. Up 83.8% patients affected with late‐onset infection. Cesarean delivery was main route, accounting for 74.6% total deliveries. Pneumonia (69, 53.1%) most common A 38 (29.2%) suffered from complications....
Background: This study was conducted to investigate the clinical features of hospital-associated infections (HAIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) in Chinese children, and molecular characteristics bacteria. Methods: Patients with HAIs MRSA were identified retrospectively. All isolates analyzed using typing antimicrobial susceptibility tests. Results: In total, 150 patients identified, a median age 18 months. The most common infection pneumonia (55.3%), followed...
Purpose: To study the anti-arthritic effect of total anthraquinone from Polygonum cuspidatum (TAPC) on type II collagen-induced arthritis (CIA) in rats, and to investigate underlying mechanism(s).Methods: CIA rats were prepared treated orally with TAPC at doses 50, 100 200 mg/kg/day, for 24 days. Paw volume score measured prior treatment, subsequently 3-day intervals days 3, 6, 9, 12, 15, 18, 21 24. Serum levels TNF-α, IL-6 IL-17 determined by enzyme-linked immunosorbent assay (ELISA), while...
Purpose: To investigate the preventive effect of resveratrol against renal pathological changes in a rat model chronic kidney disease (CKD).Methods: CKD was induced by daily intragastric administration adenine (200 mg/kg) for 1 month. The 10, 15, and 20 mg/kg doses on levels parathyroid hormone, phosphorous, fibroblast growth factor-23 (FGF-23) urine samples after 2 months were analyzed using an auto-analyzer.Results: Resveratrol treatment significantly inhibited adenine-mediated increase...
MiR-429 was reported to be downregulated in contrast-induced acute kidney injury (CI-AKI). However, whether miR-429 is functionally relevant with CI-AKI needs further investigation. Human renal tubular epithelial cell (HK-2) cells were stimulated contrast media iodixanol establish vitro model. Cell Counting Kit-8 (CCK-8) applied access viability. Flow cytometry performed determine apoptosis. Quantitative real-time polymerase chain reaction (qRT-PCR) evaluate level of programmed death 4...
Insomnia is one of the sleep disorders that seriously affect quality life people all over world. Several studies have shown acupuncture and moxibustion advantages significant curative effect high total effective rate in treatment insomnia. Traditional Chinese medicine believes insomnia heart, closely related to liver, spleen kidney, its pathogenesis Yang flourishing Yin failing, disconnecting. Western changes neurotransmitter content, endocrine dysfunction, immune inflammatory response,...
Insomnia is a non-organic sleep disorder that currently affects the quality of life people around globe, and has received widespread attention at home abroad. Current treatments such as psychotherapy, medication, physical therapy can improve patients' quality, but they have drawbacks high price, drug resistance, easy to damage skin, whereas acupuncture significant efficacy, few side effects, low ease use in treatment insomnia. Acupuncture widely recognised insomnia, research on different...
To the Editor: Chronic myelomonocytic leukemia (CMML) is characterized by both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs).[1] The rare incidence of CMML leads to difficulty establish standard criteria diagnosis specific treatment paradigms, accurate prognostic scores are required for appropriate paradigms. existing mainly included: CMML-specific (CPSS), CPSS Model (CPSS-MOL), MD Anderson scoring system (MDAPS), Global MDAPS (G-MDAPS), Groupe Francophone des...