A5057480066- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
- Spaceflight effects on biology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Radiotherapy Techniques
- T-cell and B-cell Immunology
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Genomics, phytochemicals, and oxidative stress
- Advanced Nanomaterials in Catalysis
- NF-κB Signaling Pathways
- Endometrial and Cervical Cancer Treatments
Jilin University
2016-2025
Southern Medical University
2025
Dongguan People’s Hospital
2025
Health Commission of Jilin Province
2021
Xi'an Jiaotong University
2021
Jilin Medical University
2013-2020
National Institute for Radiological Protection
2014
Shenzhen Blood Center
2011-2012
First Hospital of Jilin University
2011
Union Hospital
2010
Insufficient reactive oxygen species (ROS) production and radioresistance have consistently contributed to the failure of radiotherapy (RT). The development a biomaterial capable activating ROS-induced apoptosis ferroptosis is potential strategy enhance RT sensitivity. To achieve precision high-efficiency RT, theranostic nanoplatform Au/Cu nanodots (Au/CuNDs) were designed for dual-mode imaging, amplifying ROS generation, inducing apoptosis-ferroptosis sensitize RT. A large amount derived...
The activation of nuclear factor-kappa B1 (NFkB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency IR lung cancer, we screened for microRNAs (miRNAs) that suppress NFkB1 and observed their effects on radiosensitivity a human cell line. From time series data miRNA expression γ-irradiated H1299 cells, found miR-9 was inversely correlated with NFκB1. Overexpression down-regulated level NFκB1 surviving fraction decreased. Interestingly,...
Background Dyslipidemia and lipotoxicity-induced insulin resistance, inflammation oxidative stress are the key pathogeneses of renal damage in type 2 diabetes. Increasing evidence shows that whole-body low dose radiation (LDR) plays a critical role attenuating stress. Objective The aims present study were to investigate whether LDR can prevent diabetes-induced underlying mechanisms. Methods Mice fed with high-fat diet (HFD, 40% calories from fat) for 12 weeks induce obesity followed by...
Surgery, radiotherapy (RT), and brachytherapy are crucial treatments for localized deep tumors. However, imprecise tumor location often leads to issues such as positive surgical margins, extended target volumes, radiation damage healthy tissues. Reducing side effects in tissue enhancing RT efficacy critical challenges. To address these issues, we developed a multifunctional theranostic platform using Au/Ag nanodots (Au/AgNDs) that act "pilot light" real-time guided surgery, high-efficiency...
Repetitive exposure of diabetic mice to low-dose radiation (LDR) at 25 mGy could significantly attenuate diabetes-induced renal inflammation, oxidative damage, remodeling, and dysfunction, for which, however, the underlying mechanism remained unknown. The present study explored effects LDR on expression function Akt Nrf2 in kidney mice. C57BL/6J were used induce type 1 diabetes with multiple streptozotocin. Diabetic age-matched control irradiated whole body X-rays either single 75 or...
Exposure to ionizing radiation often induces T helper (Th) cell differentiation, resulting in an imbalance of Th1 and Th2 cellular subtypes, which can affect the efficacy cancer radiotherapy. The aim this study was analyze differential expression Th1, Th3/Type 1 regulatory (Tr1) subtype-related genes cytokines mouse thymocytes after high- low-dose systemic radiation, using functional classification gene arrays Elisa assays, explore molecular mechanisms underlying radiation's immune effects...
The present paper aims at studying the role of B7/CD28 interaction and related cytokine production in immunological changes after exposure to different doses ionizing radiation. stimulatory effect low dose radiation (LDR) on proliferative response lymphocytes Con A was found require presence APCs. addition APCs obtained from both low- high-dose-irradiated mice splenic separated low-dose-irradiated caused stimulation lymphocyte proliferation. B7-1/2 expression up-regulated high There...
In the present study, novel preventive effects of repeated low-dose radiation exposure on diabetes-induced cardiac inflammation and damage were investigated. C57BL/6J mice given multiple low doses streptozotocin (STZ, 60 mg/kg × 6) to generate type 1 diabetes. A week after last STZ injection, hyperglycemic diagnosed treated with without whole-body (25 mGy X rays) once every 2 days for 2, 4, 8, 12 16 weeks. Diabetes caused significant increases in inflammation, shown by time-dependent mRNA...
The onset of diabetic nephropathy (DN) is associated with both systemic and renal changes. Fibroblast growth factor (FGF)-21 prevents complications mainly by improving metabolism. In addition, low-dose radiation (LDR) protects mice from DN directly preventing oxidative stress inflammation. the present study, we tried to define whether combination FGF21 LDR could further prevent blocking its pathogeneses. To this end, type 2 diabetes was induced feeding a high-fat diet for 12 wk followed...
Radiotherapy (RT) is one of the most widely used treatment strategies for cervical cancer. However, radiation resistance poses a significant challenge in clinical practice, leading to poor prognosis and cancer-related deaths following RT. Herein, multifunctional bimetallic nanoplatform Au/Fe nanodots (Au/FeNDs) were constructed serve as an excellent radiosensitizer reverse resistance, aiming enhance therapeutic efficiency Au/FeNDs can generate sufficient amount reactive oxygen species...
Radiation has been shown to promote the epithelial-mesenchymal transition (EMT) in tumor cells, and TGF-β/Smad PI3K-Akt signaling pathways play an important role EMT. In this study, we investigated effects of neuropilin-1 (NRP1) on radiation-induced non-classical Smad lung cancer as well NRP1 invasion migration.Changes expression levels EMT markers (β-catenin, N-cadherin, vimentin) related transcription factors (Twist ZEB1) stably transfected cells were detected by Western blotting qPCR,...
Abstract Background: Radiation (IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment (TME). Wee1, regulator, can eliminate G2/M by phosphorylating cyclin-dependent kinase 1 (CDK1). Meanwhile, programed death-1/programed death ligand-1 (PD-1/PDL-1) blockade is closely related to TME. This study aims investigate effects mechanisms of Wee1 inhibitor AZD1775 anti-PD-1 antibody (anti-PD-1 Ab) radiosensitization hepatoma. Methods: The...
Insufficient accumulation of reactive oxygen species (ROS) due to tumor hypoxia significantly contributes increased radiation resistance and the failure radiotherapy (RT). Therefore, developing methods alleviate boost ROS levels represents a promising strategy for enhanced radiosensitivity. This study introduced self-cascade catalytic Pt@Au nanozymes as radiosensitizer, using glucose oxidase (GOx)-, catalase (CAT)-, peroxidase (POD)-like activities improve increase accumulation, thereby...
The RVG29–dextran–PTX nanoparticles can cross the BBB, reach brain glioma, and thus improve PTX efficacy.