A5066081578- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Machine Learning in Healthcare
- Telomeres, Telomerase, and Senescence
- Ultrasound Imaging and Elastography
- Cardiovascular Health and Disease Prevention
- Genomics, phytochemicals, and oxidative stress
- Photoacoustic and Ultrasonic Imaging
- Diet and metabolism studies
- Hydrogen's biological and therapeutic effects
- Muscle activation and electromyography studies
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Sports Dynamics and Biomechanics
- RNA regulation and disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiation Therapy and Dosimetry
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
Jilin University
2019-2025
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2019-2025
Tsinghua University
2022
Guangdong Medical College
2021
During radiotherapy, reactive oxygen species- (ROS-) induced apoptosis is one of the main mechanism radiation. Based on KillerRed which can induce ROS burst in different cell substructures, here we hypothesized that targeting mitochondria (mtKR) could to enhance by In this study, empty vector, mtKR, and mtmCherry plasmids were successfully constructed, mitochondrial localization detected COS-7 HeLa cells. After cells transfected irradiated visible light X-rays, levels, membrane potential (Δ...
Exposure of PM2.5 can cause different degrees lung injury, which is referred with inflammatory response. Some evidences showed that low-dose radiation (LDR) induces hormesis in immune, however, it unknown if LDR ameliorates the PM2.5-induced injury. Additionally, gut microbiota and inflammation are crucial injury health benefits through need further exploration. Here, we aim to investigate impact on vivo vitro, elucidated potential mechanisms anti-inflammation activated by microbiota. We...
Identifying novel targets for molecular radiosensitization is critical improving the efficacy of colorectal cancer (CRC) radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member SWI/SNF-like chromatin remodeling protein family, functions in maintenance genomic integrity and regulation apoptosis senescence. However, whether ATRX directly involved radiosensitivity CRC remains unclear. Our results showed that silencing increased HCT116 cells, which was further strengthened...
Abstract Respiratory diseases pose a significant global health burden, with challenges in early and accurate diagnosis due to overlapping clinical symptoms, which often leads misdiagnosis or delayed treatment. To address this issue, we developed LungDiag , an artificial intelligence (AI)‐based diagnostic system that utilizes natural language processing (NLP) extract key features from electronic records (EHRs) for the classification of respiratory diseases. This study employed large cohort...
Type 2 diabetes mellitus (T2DM) is the fastest-growing metabolic disease in world. The gut microbiota linked to T2DM. Recent studies have showed that metabolism of can trigger Low dose radiation (LDR) has been proved activate various protective bioeffects on diabetes. However, underlying mechanisms remain unclear. In this study, T2DM model was established using high fat diet combined with streptozocin (STZ) injection C57BL/6 mice, and then exposed multiple 75 mGy LDR every other day for one...
Autophagy plays a double‐edged sword for cancer; particularly, mitophagy important roles in the selective degradation of damaged mitochondria. However, whether is involved killing effects tumor cells by ionizing radiation (IR) and its underlying mechanism remain elusive. The purpose to evaluate mitochondrial ROS (mROS) on autophagy after IR; furthermore, we hypothesized that KillerRed (KR) targeting mitochondria could induce mROS generation, subsequent depolarization, accumulation Pink1,...
Radiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In current study, we investigated effect low-dose (LDR) on suppressive high-dose (HDR) its mechanism from perspective death mode DNA damage repair, aiming provide foundation improving efficacy clinical radiotherapy. We found that LDR pre-irradiation strengthened HDR-inhibited A549 proliferation, HDR-induced apoptosis,...
The clinical and economic burdens of cardiovascular diseases pose a global challenge. Growing evidence suggests an early assessment arterial stiffness can provide insights into the pathogenesis diseases. However, it remains difficult to quantitatively characterize local in vivo. Here we utilize guided axial waves continuously excited detected by ultrasound probe blood pressures mechanical properties common carotid arteries simultaneously. In pilot study 17 healthy volunteers, observe ∼ 20 %...
Background and Purpose: Oxidative stress is involved in the development of infections. However, whether oxidative indicators can be used as markers stroke-associated infection (SAI) still unclear. The purpose this study was to test predictive values superoxide dismutase (SOD) malondialdehyde (MDA) levels for SAI incidence.Methods: A total 45 consecutive patients with ischemic stroke who were admitted our hospital enrolled. prospective carried out observe occurrence during first 7 days after...
Mesoporous silica nanoparticles promote <italic>ent</italic>-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid, extracted from the Chinese herbal medicine <italic>Pteris semipinnata</italic> L., to make more important impact in treatment of low-differentiated nasopharyngeal carcinoma.
Abstract Despite the importance of radiation therapy as a non-surgical treatment for non-small cell lung cancer (NSCLC), resistance has always been concern, due to poor patient response and prognosis. Therefore, it is crucial uncover novel targets enhance radiotherapy investigate mechanisms underlying resistance. Previously, we demonstrated that NRP1 was connected in NSCLC cells. In present study, bioinformatics analysis constructed radiation-resistant A549 H1299 models revealed...
<title>Abstract</title> Background Type 2 diabetes mellitus (T2DM) is the fastest-growing metabolic disease in world. The gut microbiota linked to T2DM. Recent studies have showed that metabolism of can trigger Low dose Radiation (LDR) has been proved activate various protective bioeffects on diabetes. However, underlying mechanisms remain unclear. Method In this study, T2DM mouse model was established using high fat diet combined with streptozocin (STZ) injection, and then exposed multiple...
Introduction: Respiratory diseases pose a global health burden, and early diagnosis is crucial for effective treatment. Developing natural language processing (NLP) diagnostic system based on electronic records (EHRs) essential but challenging due to the complexity of EHR data.Methods: A retrospective study was conducted using EHRs respiratory disease patients from multiple hospitals in China. An NLP algorithm developed extract clinical features phenotypic attributes EHRs. The extracted were...
The clinical and economic burden of cardiovascular diseases (CVDs) poses a global challenge. Growing evidence suggests an early assessment arterial stiffness can provide insights into the pathogenesis CVDs. However, it remains difficult to quantitatively characterize in vivo. Here we utilize guided elastic waves continuously excited detected by ultrasound as tool probe blood pressure (BP) mechanical properties common carotid artery (CCA) simultaneously. In pilot study 17 healthy volunteers,...
Abstract Identifying novel targets for molecular radiosensitization is critical to improve the efficacy of cancer radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member SWI/SNF-like chromatin remodeling protein family, functions in maintenance genomic integrity, alternative lengthening telomeres, and regulation apoptosis senescence. However, whether ATRX directly involved DNA damage response (DDR) remains unknown. Here, we show that silencing increased sensitivity cells...
Abstract Background: Alpha-thalassemia/mental retardation X-linked (ATRX), a member of the SWI/SNF-like chromatin remodeling protein family, functions in maintenance genomic integrity, alternative lengthening telomeres, and regulation apoptosis senescence. However, whether ATRX is directly involved DNA damage response (DDR) remains unknown. Here, we Identify novel targets for molecular radiosensitization cancer radiotherapy. Methods: ATRX-depleted HeLa cell lines were obtained by RNAi, after...
Background. Radiation resistance of lung cancer cells is a vital factor affecting the curative effect cancer. Transcription GATA3 involved in cell proliferation, invasion, and migration significantly expressed variety malignancies. However, molecular mechanism governing regulation cells’ radiation unknown. Methods. Radiation-resistant models (A549-RR H1299-RR) were made using fractionated high-dose irradiation. Use clone formation, CCK-8, F-actin staining, cycle detection, other experiments...
Shear wave elastography of human skeletal muscles enables the measurement muscle elastic properties in vivo and finds important applications sport medicine diagnosis therapy muscle-related diseases. Previous SWE methods for rely on passive constitutive theory are unable to provide parameters describing active behavior so far. We overcome this limitation present paper by proposing a method quantitatively infer vivo. To end, we investigate motion described with model which has been defined. An...