A5062657734- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Climate Change and Health Impacts
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Heme Oxygenase-1 and Carbon Monoxide
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Inflammation biomarkers and pathways
- Building Energy and Comfort Optimization
- Traditional Chinese Medicine Analysis
- GDF15 and Related Biomarkers
- Prion Diseases and Protein Misfolding
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Protein Tyrosine Phosphatases
Second Affiliated Hospital of Guangzhou Medical University
2015-2024
Guangzhou Medical University
2015-2024
First Hospital of Lanzhou University
2016
Chenzhou First People's Hospital
2016
Southern Medical University
2016
Inner Mongolia Medical University
2016
Nanfang Hospital
2016
Zhujiang Hospital
2016
Hunan Provincial People's Hospital
2016
Wenzhou Medical University
2016
The aim was to describe the clinical, radiological and pathological features of an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.Data from 19 patients with positive GFAP-immunoglobulin G in cerebrospinal fluid (CSF) were retrospectively analyzed.The main disease manifestations included myelitis (68.4%), headache (63.2%), abnormal vision fever (52.6%), ataxia (36.8%), psychosis (31.6%), dyskinesia (15.8%), dementia (15.8%) seizure (10.5%). Seventeen had brain abnormalities...
Background and Purpose— We aimed to develop validate a grading scale for predicting 30-day mortality 90-day functional outcome in patients with primary pontine hemorrhage (PPH). Methods— retrospectively reviewed records of consecutive first-ever from 3 teaching hospitals between 2005 2012. Independent factors associated were identified by logistic regression establish risk stratification scale, named the new PPH score. For validation score, we prospectively recruited subjects 10 units...
In contrast to the previous COVID-19 pandemic, most frontline healthcare workers (HCWs) worked on residents' nucleic acid tests in outdoor environments, instead of taking care patients hospitals during hot summer 2021. Therefore, it is necessary investigate prevalence and characteristics thermal discomfort caused by personal protective equipment (PPE). A cross-sectional survey was conducted online at from 11 administrative regions Guangzhou for assessment among HCWs June 12–16, Univariate...
Cerebral ischemia-reperfusion injury (IRI) has a complex pathogenesis, and interleukin-17 (IL-17) is newly identified class of the cytokine family that plays an important role in ischemic inflammation. An oxygen-glucose deprivation (OGD) model showed IL-17A expression was significantly up-regulated microglial cells. After siRNA transfection, inhibition proliferation increased apoptosis cells, induced by OGD/reperfusion, obviously improved, elevation Caspase-3, Caspase-8, Caspase-9 poly ADP...
Background:Previous studies have reported that the total bilirubin (TB) level is associated with coronary artery disease, heart failure and atrial fibrillation. These diseases can produce cardiogenic cerebral embolism cause cardioembolic stroke. However, whether serum TB could be a biomarker to differentiate stroke from other subtypes unclear.Methods:Our study consisted of 628 consecutive patients ischaemic Various clinical laboratory variables were analysed according quartiles...
Background: Although rare, brain abnormalities without optic neuritis (ON) or transverse myelitis (TM) diagnosed with neuromyelitis optica spectrum disorder (NMOSD) have been reported in patients positive for the aquaporin-4 (AQP4) antibody. Objective: To analyze demographic and clinical differences among NMOSD ON TM, those either simultaneous TM at disease onset. Methods: In this retrospective study, were recruited who AQP4 antibody, as detected using a cell-based assay, Second Affiliated...
Since the advent of coronavirus disease 2019 (COVID-19), healthcare workers (HCWs) wearing personal protective equipment (PPE) has become a common phenomenon. COVID-19 outbreaks overlap with heat waves, and must unfortunately wear PPE during hot weather experience excessive stress. Healthcare are at risk developing heat-related health problems periods in South China. The investigation thermal response to stress among HCWs when they do not finish work PPE, impact use on HCWs’ physical were...
Several prior studies have linked serum prealbumin (PA) as a predictor for perioperative infection. However, whether peripheral blood PA levels can be used an indicator of stroke-associated infection (SAI) is still unclear. In this study, we attempt to find meaningful in SAI after ischemic stroke, so provide theoretical basis clinical treatment.Consecutive patients with acute stroke who were admitted our hospital enrolled and was collected. A prospective study conducted observe the...
Aquaporin-4 (AQP4) antibody sero-positivity is critically important in neuromyelitis optica (NMO). However, the sensitivity of different assays highly variable. Repeating detection with a sensitive assay large population necessary case so-called negative NMO.Retrospective analysis where AQP4 antibodies were detected by commercial cell-based (CBA), in-house M23-CBA and M1-CBA.Of 1011 serum samples, 206 (20.4%) sero-positive primary CBA. In retest, all participants positive CBA also yielded...
To analyze changes in magnetic resonance imaging (MRI) of spinal cord lesions neuromyelitis optica (NMO) and the correlation between segmental length expanded disability status scale (EDSS) scores.Twenty-five patients with confirmed NMO were examined from Second Affiliated Hospital Guangzhou Medical University, China. The information collected included their treatment, MRI, laboratory tests, EDSS scores at different stages.All cases exhibited lesions, 23 (92%) having longitudinally extensive...
Background and Purpose: Oxidative stress is involved in the development of infections. However, whether oxidative indicators can be used as markers stroke-associated infection (SAI) still unclear. The purpose this study was to test predictive values superoxide dismutase (SOD) malondialdehyde (MDA) levels for SAI incidence.Methods: A total 45 consecutive patients with ischemic stroke who were admitted our hospital enrolled. prospective carried out observe occurrence during first 7 days after...
The aim of the study was to serum peroxisome proliferator-activated receptor gamma (PPARγ) level and PPARγ gene polymorphism as well severity prognosis brain injury in patients with arteriosclotic cerebral infarction (ACI). A total 246 ACI presenting at Department Neurology Zengcheng District People's Hospital Guangzhou between April 2009 July 2015 were selected case group, 382 control subjects enrolled group. hepatic renal functions homocysteine (Hcy) expression levels measured....
Objective To investigate the correlations of serum total bilirubin level with infarct volume, severity and etiological typing in patients acute ischemic stroke. Methods Patients stroke admitted to hospital from January 2012 2014 were used as subjects study. Their clinical imaging data collected, levels detected. The analyzed. Results A 290 enrolled divided into either a large infarction group(≥1.8 cm3,n=145)or small group( 17.893 μmol/L)was an independent risk factor for...
Objective To investigate the correlations of plasma brain natriuretic peptide （BNP） levels and subtypes severity acute ischemic stroke. Methods Consecutive patients with stroke were enrolled in study. They divided into large-artery atherosclerosis （LAA）, small- artery occlusion （SAO） cardioembolism （CE） according to Trial Org 10172 Acute Stroke Treatment （TOAST） classification. Electrochemiluminescence immtmoassay was used measure plasmaBNP. OsiriX software calculate cerebral infarction...