The aim was to describe the clinical, radiological and pathological features of an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.Data from 19 patients with positive GFAP-immunoglobulin G in cerebrospinal fluid (CSF) were retrospectively analyzed.The main disease manifestations included myelitis (68.4%), headache (63.2%), abnormal vision fever (52.6%), ataxia (36.8%), psychosis (31.6%), dyskinesia (15.8%), dementia (15.8%) seizure (10.5%). Seventeen had brain abnormalities...

Mendelian randomization (MR) analysis was used to determine the causal relationship between Type 2 diabetes (T2D) and osteomyelitis (OM). We performed MR using pooled data from different large-scale genome-wide association studies (GWAS). Instrumental variables were selected based on significance, instrumental strength assessed F-values, thresholds for number of exposed phenotypes further adjusted by Bonferroni correction. univariable multivariable analyses assess effects proportions...

Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. The aim this study was to investigate the association CYP1A1 polymorphisms with male infertility Han-Chinese population. We genotyped two polymorphisms, CYP1A1*2A and CYP1A1*2C, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay hospital-based case-control including 192 infertile patients...

The accelerated aging process worldwide is placing a heavy burden on countries. PM

The transcription factor NFIL3 exerts comprehensive effects on the immune system. Previous studies revealed that is related to function and development of different cell subsets. Experimental autoimmune encephalomyelitis (EAE) mediated by cells which results in inflammatory demyelination central nervous system (CNS). However, how affects EAE has not been thoroughly studied.The current study aimed investigate EAE, especially changes T dendritic as well crosstalk between them.We used NFIL3-/-...

To explore the correlation between platelet endothelial aggregation receptor-1 (PEAR1) genetic polymorphism and pulmonary thromboembolism (PTE). Variant loci of PEAR1 gene were screened in a PTE pedigree, followed by verification using Sanger sequencing. These polymorphic validated 101 patients 132 matched normal MassARRAY single nucleotide (SNP) genotyping methods. The frequency differences allele genotypes compared Hardy–Weinberg equilibrium test Chi-square test. SNP was analyzed comparing...

Calreticulin has been identified to play a critical role in innate and adaptive immune responses. However, little is known about the of calreticulin sepsis with characteristic disorder. This study was aimed at investigating whether plasma level increases its association severity. retrospective analysis evaluated patients who were admitted intensive care unit (ICU). Healthy subjects also included as controls. Plasma samples collected from within 48 h after ICU admission well healthy subjects....

<b><i>Background and Objective:</i></b> Plasma homocysteine (Hcy) levels have been investigated among patients with multiple sclerosis (MS). However, the changes in Hcy association between inflammatory/immune/cerebrospinal fluid (CSF) parameters neuromyelitis optica spectrum disorder (NMOSD) not yet. <b><i>Methods:</i></b> Case data were collected from 97 acute-phase NMOSD 39 stable-phase patients. Patients acute phase divided into 2 groups...

Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes Hcy anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis not thus far. Methods: Case data were collected from 46 patients with anti-NMDAR 179 age- sex-matched healthy controls (HCs). Clinical characteristics, levels, C reactive protein (CRP) cerebrospinal fluid (CSF) parameters determined. Association of clinical evaluated these patients....

<b><i>Background and Objective:</i></b> Limited studies are available for male patients with anti-aquaporin-4 antibody (AQP4-Ab)-positive late-onset neuromyelitis optica spectrum disease (LONMOSD). The aim of this study was to investigate the clinical characteristics Chinese AQP4-Ab-positive LONMOSD. <b><i>Methods:</i></b> We retrospectively reviewed medical records 12 LONMOSD, 16 early-onset NMOSD (EONMOSD), 64 female These enrolled were...

Imprinted in placenta and liver ( IPL ) gene has been identified as an imprinted the mouse human. Its sequence imprinting status, however, have not determined domestic pigs. In present study, a 259 base pair-specific for of pig was obtained novel SNP, T/C transition, exon 1. The C allele this polymorphism found to be predominant Landrace,Yorkshire, Duroc. frequency CC genotype are different Duroc compared with Yorkshire (<mml:math...

Objective: To investigate the therapeutic effect of Biling Weitong Granules combined with oryz-aspergillus enzyme and pancreatin tablets on patients reflux esophagitis functional dyspepsia. Methods: Sixty diagnosed dyspepsia who were admitted to Affiliated Hospital Hebei University between June 2020 2023 selected divided into two groups: control group observation group, each consisting 30 cases. The received only, while in addition tablets. clinical efficacy, Chinese medicine syndrome...

As lumbar degenerative diseases become more prevalent in an aging population, there is increasing demand for surgical interventions, such as posterior interbody fusion (PLIF). However, cage subsidence (CS), observed 23.9–54% of cases postoperatively, remains a significant complication. Several factors, including age, bone quality, and endplate damage, contribute to the risk CS, with quality being among most critical determinants. Although DEXA QCT are widely employed assess density, their...

Rationale: The aim of this study is to investigate the de novo mutation and clinical features latent transforming growth factor-beta-binding protein 3 (LTBP3) gene-associated geleophysic dysplasia 3, possible mechanisms action. Patient concerns: A nonconsanguineous couple was recruited for due presence intrauterine restriction. pregnant woman her elder daughter presented with skeletal abnormalities diabetes. underwent amniocentesis cytogenetic analysis copy number variation sequencing....

Abstract Introduction Although over 1000 hemoglobin (Hb) variants were identified so far, Hb Port Phillip compound with α‐thalassemia deletion had no reported before. Methods Two patients and the associated families from Guangdong province in China recruited. Hematological parameters determined by blood routine examination electrophoresis. Genotyping was performed Gap‐PCR Sanger sequencing. Results One patient diagnosed as Phillip, while her daughter compounded ‐α4.2 deletion, normal level...

With the maturity of hardware and software virtual reality decline in equipment costs, wide application technology has become possible, it focus discussion education teaching field. Simultaneously, also brings new opportunities challenges to current practical higher education. For universities, is important challenging not only provide students with an imaginative, exploring authentic practice environment, but build positive, open free space-time space for students, which difficult achieve...

Objective To investigate the level of thyroid hormone in Xinjiang Uygur and Han old people with mild cognitive dysfunction (MCI), to provide basis for early intervention MCI. Methods Case control study was carried out among 5398 residents who above 60 years Xinjiang, Uyghur ,from July 2008 October 2010.According diagnosis MCI by American Psychiatric Society DSM-Ⅳ, 314 patients were diagnosed matching 299 healthy as group.Serum T3 (triiodothyronine), T4 (thyroxine) TSH (thyroid...