A5044304844- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Child and Adolescent Psychosocial and Emotional Development
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Child Abuse and Trauma
- Signaling Pathways in Disease
- Suicide and Self-Harm Studies
- Corporate Finance and Governance
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Sleep and related disorders
- Prenatal Substance Exposure Effects
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- Youth Substance Use and School Attendance
- Inflammatory Bowel Disease
- Maternal Mental Health During Pregnancy and Postpartum
- Atmospheric chemistry and aerosols
- Cancer, Hypoxia, and Metabolism
- Toxic Organic Pollutants Impact
- Cholangiocarcinoma and Gallbladder Cancer Studies
Guangdong Medical College
2016-2025
Wuhan University of Technology
2024
Tsinghua University
2001-2024
China Southern Power Grid (China)
2023-2024
Hangzhou Normal University
2023-2024
Southwest Minzu University
2023
Sichuan University
2022
China University of Mining and Technology
2010-2021
The University of Texas MD Anderson Cancer Center
2020
Guangdong Province Environmental Monitoring Center
2014-2019
Abstract Background and Aim: Circulating miRNAs exist in serum plasma they can be used as a potential noninvasive molecular marker for colorectal cancer (CRC) diagnosis. The present study was to test the availability of direct amplification from without RNA extraction, evaluate its clinical application value CRC. Methods: Plasma miR‐21, miR‐221 miR‐222 levels were determined 103 CRC patients 37 healthy normal controls by quantitative reverse transcription‐polymerase chain reaction....
The COVID-19 outbreak seriously affected all economies, especially the operations of listed companies, around world. This article studies impact on firm-level cash holdings using difference-in-differences method. It finds that has a significant positive in serious-impact industries. Goodwill and goodwill impairment can weaken this impact, which may be related to higher business risks these firms. Therefore, managers should raise firms' holding level during pandemic protect firms against...
To investigate the prevalence and correlates of sleep disturbance depressive symptoms among Chinese adolescents to examine association between two problems.Cross-sectional survey.A total 3186 school students in grades 7-12 were sampled from schools Guangdong. A stratified-cluster random-sampling strategy was used select schools.A self-administered questionnaire used. The Pittsburgh Sleep Quality index (PSQI) assess occurrence disturbance, Center for Epidemiology Scale Depression (CES-D)...
Background and aims This large-scale study aimed to test (a) associations of problematic Internet use (PIU) sleep disturbance with suicidal ideation suicide attempts among Chinese adolescents (b) whether mediates the association between PIU behavior. Methods Data were drawn from 2017 National School-based Adolescents Health Survey. A total 20,895 students’ questionnaires qualified for analysis. The Young’s Addiction Test was used assess PIU, level measured by Pittsburgh Sleep Quality Index....
This study aims to identify prognostic microRNAs (miRNAs) biomarkers for diagnosis and survival of hepatocellular carcinoma (HCC) based on large patients cohort analysis. HCC patient data were downloaded from The Cancer Genome Atlas, including paired adjacent non-cancer tissues. Receiver operating characteristic curve method was used classify cancer tissues according expression levels. aberrant level ranked risked building a miRNAs signature model. Kaplan-Meier analyze the differences among...
To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with pyknon motif), and to characterise potential as biomarker therapeutic target.FLANC expression was analysed in 349 tumours from four cohorts correlated clinical data. In series multiple vitro vivo models molecular analyses, we characterised fundamental biological roles this lncRNA. We further explored targeting FLANC mouse model colorectal cancer...
MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim this study is to identify miRNA expression signatures hepatocellular carcinoma delineate their clinical significance for carcinoma.Patients with carcinoma, undergoing hepatectomy were randomly divided into training set (60 patients) test (50 patients). Other 56 patients used as an independent cohort. levels detected by microarray verified quantitative real-time reverse transcription-PCR (qRT-PCR).A...
<h3>Importance</h3> Suicidal behavior is a leading cause of injury and death worldwide, previous cross-sectional studies have demonstrated that nonmedical use prescription drugs (NMUPD) was associated with suicidality. However, there not any study in China having examined the longitudinal relationships between NMUPD, suicidal ideation, attempts, as well explored potential mediating effects depressive symptoms. <h3>Objective</h3> To determine whether baseline NMUPD subsequent ideation...
Objective To determine whether involvement in bullying as a bully, victim, or bully-victim was associated with higher risk of poor sleep quality among high school students China. Methods A cross-sectional study conducted. total 23,877 were surveyed six cities Guangdong Province. All asked to complete the adolescent health status questionnaire, which included Chinese version Pittsburgh Sleep Quality Index (PSQI) and involvement. Descriptive statistics used evaluate prevalence bullying....
Extra-nodal natural killer T-Cell (NK/T-cell) lymphoma is a progressive cancer with poor prognosis due to the lack of disease specific treatment. To develop therapeutic strategies, it essential identify tumor markers. Recent studies show that circulating microRNA (miRNA) may serve as diagnostic and/or prognostic markers for some diseases. explore miRNAs potential NK/T-cell lymphoma, in our study, we compared miR-221 levels 79 patients and 37 normal subjects by real-time PCR amplification...
Extra-nodal natural killer T-Cell (NK/T-cell) lymphoma is a progressive cancer with poor prognosis due to the lack of disease specific treatment. To develop therapeutic strategies, it essential identify tumor markers. Recent studies show that circulating microRNA (miRNA) may serve as diagnostic and/or prognostic markers for some diseases. explore miRNAs potential NK/T-cell lymphoma, in our study, we compared miR-221 levels 79 patients and 37 normal subjects by real-time PCR amplification...
Colorectal cancer (CRC) is the third most common and fourth leading cause of cancer‑associated mortalities worldwide. MicroRNAs (miRNAs/miRs) serve important roles in tumor development, progression metastasis. miR‑221 has been reported to modulate proliferation, apoptosis, cell cycle distribution migration a variety cancers. However, function autophagy unclear. In present study, role CRC cells was investigated its associated target identified. Survival analysis using The Cancer Genome Atlas...
Abstract The aim of this study was to examine the association between cigarette smoking, alcohol consumption and depressive symptoms among adolescents, with a particular focus on gender differences. A total 19,578 middle high school students in Chongqing Province were surveyed. Self-reported consumption, family- school-related factors assessed. 8.8% adolescents reported smoking cigarettes. Tobacco use by boys (16.5%) significantly higher than girls (1.9%). Approximately 23.5% consumption....
The relationship of bullying with suicidal ideation among adolescents is controversial. Although depression has been related to and ideation, little known about the combined impacts on ideation. A sample 20,509 high school students from Fujian Province were selected randomly by multistage stratified sampling. All participants completed an adolescent health status questionnaire. Three categories assessed: perpetration, victimization, both (victimization perpetration). associations these 3...
Abstract Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, molecular mechanisms by which HQT protects colon are unclear. We studied protective effects and underlying an experimental mouse model vitro. In vivo , dextran sodium sulphate (DSS)-induced acute chronic colitis were significantly ameliorated as gauged phenotypic, histopathologic manifestations disease. Mechanistically, DSS-induced...
The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series experiments both vitro vivo were used to characterize promotive NPC tumorigenesis identify prolyl isomerase Pin1 as novel regulator at post-transcription. First, we found that overexpression promoted colony formation NPC. However, high protein level not resulted from mRNA level....