A5101508192- Endometrial and Cervical Cancer Treatments
- Management of metastatic bone disease
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Colorectal and Anal Carcinomas
- Pancreatitis Pathology and Treatment
- Sarcoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Abdominal vascular conditions and treatments
- Nanoparticle-Based Drug Delivery
- Peripheral Nerve Disorders
- Acute Myeloid Leukemia Research
- Autoimmune Neurological Disorders and Treatments
- Advanced Materials and Mechanics
- Radiation Therapy and Dosimetry
Hubei University of Chinese Medicine
2023-2025
Hebei Medical University
2012-2025
Hebei General Hospital
2012-2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Second Affiliated Hospital of Jilin University
2016-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Jilin University
2017-2023
Dazhou Central Hospital
2023
Abstract Conductive hydrogels have recently gained impressive attention in biological medicine and intelligent electronics. Despite the multifunctions demonstrated by existing conductive hydrogels, it is still a challenge to introduce hydrogel adjust distance between peritumoral organs tumor, reducing radiation damage organs. Here, hydrophobic associating with multiple desirable features fabricated based on diverse supramolecular assembly. The introduction of MXene hydrolyzed keratin (HK)...
Surgery, radiotherapy (RT), and brachytherapy are crucial treatments for localized deep tumors. However, imprecise tumor location often leads to issues such as positive surgical margins, extended target volumes, radiation damage healthy tissues. Reducing side effects in tissue enhancing RT efficacy critical challenges. To address these issues, we developed a multifunctional theranostic platform using Au/Ag nanodots (Au/AgNDs) that act "pilot light" real-time guided surgery, high-efficiency...
With the potential for fast, contactless and environmentally friendly delivery, unmanned aerial vehicles (UAVs) have gained increasing attention application due to their cost-effectiveness convenient rapid delivery operations. In future cities, a multi-level airport that supports vertical take-off landing (VTOL) of UAVs forming network is necessary improve efficiency provide competitive advantage. This paper proposes location-routing problem considers UAV flight energy consumption...
Large-scale language models have demonstrated robust understanding and generation capabilities, enabling them to tackle various complex natural processing tasks. However, for domain-specific tasks like healthcare that require specialized expertise, relying solely on large dialogue is insufficient. Moreover, this paper aims improve the performance of in medical conversations enhance interpretability intermediary processes. It argues leveraging diverse knowledge agent-based architecture can...
Radiotherapy (RT) is one of the most widely used treatment strategies for cervical cancer. However, radiation resistance poses a significant challenge in clinical practice, leading to poor prognosis and cancer-related deaths following RT. Herein, multifunctional bimetallic nanoplatform Au/Fe nanodots (Au/FeNDs) were constructed serve as an excellent radiosensitizer reverse resistance, aiming enhance therapeutic efficiency Au/FeNDs can generate sufficient amount reactive oxygen species...
Insufficient accumulation of reactive oxygen species (ROS) due to tumor hypoxia significantly contributes increased radiation resistance and the failure radiotherapy (RT). Therefore, developing methods alleviate boost ROS levels represents a promising strategy for enhanced radiosensitivity. This study introduced self-cascade catalytic Pt@Au nanozymes as radiosensitizer, using glucose oxidase (GOx)-, catalase (CAT)-, peroxidase (POD)-like activities improve increase accumulation, thereby...
Objective We present a new technique of 3-dimensional computed tomography–guided interstitial (IS) brachytherapy (BT) for locally advanced cervical cancer, offering more advantageous clinical treatment approach. Materials/Methods Interstitial BT was performed using an applicator combining uterine tandem and metal needles; needles were inserted freehand under real-time tomography guidance. Twenty-eight patients with bulky tumors and/or parametrial extension (tumor size > 5 cm) after...
Abstract Human leukocyte antigen (HLA) class I allelic genotypes were determined in 105 unrelated Han ethnic individuals inhabiting the northern China area. A total of 19 HLA‐A alleles, 49 HLA‐B alleles and 24 HLA‐Cw detected. Through analyses two three loci haplotypes HLA‐A, HLA‐B, HLA‐C loci, 11 HLA‐A‐B‐Cw haplotypes, HLA‐A‐B 18 HLA‐A‐Cw HLA‐B‐Cw with frequencies higher than 0.01 revealed. The Nei's genetic distance (GD) was estimated, NJ dendrogram showed that Northern had a GD to...
Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents new technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT).Sixteen patients with recurrent radical external-beam (EBRT) were included in this study. These underwent high-dose-rate (HDR) BT free-hand placement of metal needles 3D-CT. Six Gy 6 fractions prescribed the high-risk clinical...
The Radiation Therapy Oncology Group reported a maximum tolerated dose of 74 Gy for patients with non-small cell lung cancer (NSCLC); however, it was unclear whether this could be safely administered to Asian due differences in their physique compared Western patients. We therefore conducted modified Phase I trial determine 70 delivered Chinese NSCLC undergoing 3D-conformal radiation therapy (3D-CRT) concurrent chemotherapy. Previously untreated received 3D-CRT (2 Gy/day, 5 fractions per...
Objective: To explore the factors influencing early treatment responses in adult with de novo acute myeloid leukemia (AML) . Methods: Data of consecutive newly-diagnosed AML (non-acute promyelocytic leukemia) adults were analyzed retrospectively. assess impact clinical characteristics at diagnosis and induction regimen on achieving morphologic leukemia-free state (MLFS) , blood counts minimal residual (MRD, positive MRD defined as RQ-PCR WT1 mRNA ≥0.6% and/or any level abnormal blast...
Purpose The aim of this study is to evaluate the efficacy and toxicity image-guided high-dose rate (HDR) interstitial brachytherapy (ISBT) for reirradiation cervical cancer within a previously irradiated area. Methods materials Twenty-three consecutive patients with were reirradiated curative intent using (BT) or without external beam irradiation. median biologically equivalent dose in 2-Gy fractions (EQD2) was 64.0 Gy (range: 31.3–95.1 Gy), cumulative EQD2 (for primary treatment...
Abstract Objective: This study aimed to identify differentially expressed genes associated with early gastric cancer and analyze their potential functions through bioinformatics analysis. Additionally, we sought validate the genetic causality of identified differential molecules related using Mendelian randomization. Methods: We analyzed expression profiles 19 gastritis specimens 20 (high-grade intraepithelial neoplasia) from GEO database combined gene analysis weighted co-expression network...
Crohn's disease (CD) presents significant diagnostic and therapeutic challenges due to its unclear etiology, frequent relapses, limited treatment options. Traditional monitoring often relies on invasive costly gastrointestinal procedures. This study aimed identify specific markers for CD using advanced computational approaches. Four gene expression datasets from the Gene Expression Omnibus (GEO) were analyzed, identifying differentially expressed genes (DEGs) through set enrichment analysis...
Abstract: A novel human leukocyte antigen (HLA)‐DQB1 allele, DQB1*020102, was detected in a 28‐year‐old woman of Han ethnic Guangzhou, China. Compared with HLA‐DQB1*020101 and HLA‐DQB1*0202, they differed only one nucleotide at the position 167 (C to T) exon 2, which highly conserved position. This is synonymous mutation, does not cause any change amino acid sequence mature protein.
Objective: The goal of this study was to evaluate the efficacy and safety modified (accelerated and/or hyperfractionated) radiotherapy in treatment esophageal carcinoma, compared with conventional radiotherapy. Methods: Studies published PubMed, Cochrane Library, EMBASE, CBM, VIP, CNKI Wanfang databases most recent two decades were searched for use meta-analysis. Only randomized controlled trials included. heterogeneity analysis calculation pooled odds ratio (OR) performed using RevMan 5.3...