A5019125981- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Healthcare and Venom Research
- Urticaria and Related Conditions
- Infection Control in Healthcare
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Biochemical effects in animals
- Psychosomatic Disorders and Their Treatments
- Antibiotic Use and Resistance
- Cannabis and Cannabinoid Research
- Music Therapy and Health
- Endoplasmic Reticulum Stress and Disease
- Caveolin-1 and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic function and diabetes
- Cardiovascular and Diving-Related Complications
- Ion Channels and Receptors
- HIV/AIDS drug development and treatment
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Healthcare Decision-Making and Restraints
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
China North Industries Group Corporation (China)
2024
Icahn School of Medicine at Mount Sinai
2023
Washington University in St. Louis
2020-2022
Xuzhou Medical College
2022
University of Washington
2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Background Paclitaxel is commonly used as a cancer chemotherapy drug that frequently causes peripheral neuropathic pain. Inflammasome multiprotein complex consisting of Nod-like receptor proteins (NLRPs), apoptosis-associated speck-like protein, and caspase-1, which functions to switch on the inflammatory process release interleukin-1β. Growing evidences have supported interleukin-1β critical in enhancing paclitaxel-induced However, whether activation NLRP3 inflammasome nerve contributes...
Abstract Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role GRP in sensory neurons, we generated floxed Grp mouse line. We found that conditional knockout results attenuated without impairing histamine-induced itch. Using -Cre knock-in line, show upper epidermis skin is exclusively innervated by fibers, whose activation via optogeneics and...
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, and it typical disease which can develop pain. Although electroacupuncture (EA) effective in relieving pain clinic, the involved mechanisms remain unclear. Reduced diffuse noxius inhibitory controls (DNIC) function associated with pain, may be related to deficit of endocannabinoids. In present study, we determine whether EA potentiate cannabinoid receptor mediated descending control inhibit mouse model KOA. We found...
Background Electroacupuncture (EA) is effective in relieving pain patients with postherpetic neuralgia (PHN). However, the mechanism underlying therapeutic effect of EA PHN still unclear. Systemic injection resiniferatoxin (RTX), an ultrapotent analog TRPV1 agonist, adult rats can reproduce clinical symptoms by ablating TRPV1-expressing sensory neurons. In this study, we determined beneficial and potential mechanisms rat model PHN. Methods was induced a single RTX. Thermal hyperalgesia...
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, with pain as its typical symptom. Although studies have shown that an activated peripheral CB2 receptor can reduce acute pain, whether the involved in electroacupuncture (EA) inhibiting and mechanism remains unclear. The aim of this study was to investigate EA may strengthen receptor-inhibited mouse model KOA.KOA induced by intra-articular injection monosodium iodoacetate (MIA) into left knee mice. Thermal hyperalgesia...
Multiple system atrophy (MSA) is regarded as a progressive neurodegenerative disease mainly divided into MSA-p type with Parkinsonism and MSA-c cerebellar ataxia the main symptom. However, its neural mechanism still unclear. In this study, we only focus on type. The purpose of study to explore functional connectivity changes cerebello-cortical circuit in by using resting state magnetic resonance imaging (rs-fMRI). Thirty-six subjects (18 MSA 18 normal controls) participated rs-fMRI data were...
Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival social animals. Gastrin-releasing peptide (GRP) its receptor (GRPR) in suprachiasmatic nucleus (SCN) hypothalamus mediates contagious mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual information, independently melanopsin, from to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR relay information paraventricular thalamus (PVT)....
Abstract Background Spinal microglia activation is one of the pathologic mechanisms involved in post‐operative pain, which results from surgical injuries skin, fascia, muscle and small nerves innervating these tissues. Recent research has shown that neuregulin‐1 ( NRG 1) its receptor erythroblastosis oncogene B ErbB ) family mediate proliferation chemotaxis contributing to development neuropathic pain. However, it unclear whether 1‐ signalling contributes incision‐induced mechanical...
Abstract Obstructive sleep apnea syndrome (OSAS) is a complete or partial airway obstruction that causes significant physiologic disturbance with various clinical impacts. The aim of the study was to determine risk factors associated severity OSAS. 303 patients OSAS and 199 without enrolled in disorder center from 2017 2019 were included study. All completed physical examination, Epworth sleepiness scale, polysomnography. By apnea–hypopnea index (AHI), separated into four subsets: AHI < 5...
Histamine-dependent and -independent itch is conveyed by parallel peripheral neural pathways that express gastrin-releasing peptide (GRP) neuromedin B (NMB), respectively, to the spinal cord of mice. B-type natriuretic (BNP) has been proposed transmit both types via its receptor NPRA encoded Npr1 . However, BNP also binds cognate receptor, NPRC Npr3 with equal potency. Moreover, peptides (NP) signal through G i -couped inhibitory cGMP pathway supposed inhibit neuronal activity, raising...
Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in variety pain models. Postherpetic neuralgia (Shingles) neuropathic conditioned presence profound allodynia. Systemic injection resiniferatoxin can reproduce clinical symptoms postherpetic neuralgia. In this study, we determined to study whether activation contributes cleave myelin basic protein dorsal root involved...
Detection of healthcare-associated infection (HCAI) clusters is crucial in limiting disease transmission.To investigate whether data on antibiotic use can be an alternative indicator for the identification HCAI caused by multidrug-resistant organisms (MDROs).We retrospectively analysed MDRO-related HCAIs and 10 indicators from four independent high-risk units at a tertiary hospital China January 2014 to 2017. Spearman's correlation test was used evaluate correlations between variables,...
Recent studies have implicated the activation of p38 mitogen-activated protein kinase (MAPK) and glial cells contribute to hyperalgesia following nerve injury or compression. In our work, we investigated underlying mechanisms autologous nucleus pulposus (NP)-induced mechanical in a modified rat model lumbar disk herniation (LDH). Firstly, results showed that 50% withdrawal threshold (50% MWT) decreased on postoperative day (POD) 1 significantly minimally reduced POD 7 lasted for 28 after...
The aim of this study was to evaluate the impact hyperbaric oxygen therapy (HBOT) on patients with SARS-CoV-2 infection and determine its efficacy safety in reducing treatment failure events. A retrospective cohort involving COVID-19 conducted. Inverse probability weighting (IPTW) used balance covariates between HBOT non-HBOT groups. primary endpoint occurrence a clinical event, defined as all-cause mortality, abandonment treatment, or transfer Intensive Care Unit due worsening condition....