A5042786100- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Healthcare and Venom Research
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Ion Channels and Receptors
- Neuroscience and Neural Engineering
- Bee Products Chemical Analysis
- Dermatology and Skin Diseases
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Olfactory and Sensory Function Studies
- Myofascial pain diagnosis and treatment
- Herbal Medicine Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Urticaria and Related Conditions
- Exercise and Physiological Responses
- Photoreceptor and optogenetics research
- Innovations in Medical Education
- Cervical Cancer and HPV Research
Air Force Medical University
2012-2023
Northwest University
2023
Washington University in St. Louis
2017-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Development of chronic pain involves alterations in peripheral nociceptors as well elevated neuronal activity multiple regions the CNS. Previous pharmacological and behavioral studies suggest that acid-sensing ion channels (ASICs) contribute to sensation, expression ASIC subunits is rat spinal dorsal horn (SDH) an inflammatory model. However, cellular distribution functional consequence increased subunit SDH remain unclear. Here, we identify Ca 2+ -permeable, homomeric ASIC1a predominant...
To scratch or not to Observing someone else scratching themselves can make you want do so. This contagious itching has been observed in monkeys and humans, but what about rodents? Yu et al. found that mice imitate when they observe it other mice. The authors identified a brain area called the suprachiasmatic nucleus as key circuit for mediating itch. Gastrin-releasing peptide its receptor were necessary sufficient transmit this behavior. Science , issue p. 1072
Tetrodotoxin-resistant (TTX-R) sodium channels NaV1.8 and NaV1.9 in sensory neurons were known as key pain modulators. Comparing with the widely reported NaV1.8, roles of on inflammatory are poorly studied by antisense-induced specific gene knockdown. Here, we used molecular, electrophysiological behavioral methods to examine effects antisense oligodeoxynucleotide (AS ODN) targeting pain. Following complete Freund's adjuvant (CFA) inflammation treatment, rat dorsal root ganglion (DRG)...
Pain can be socially transferred between familiar rats due to empathic responses. To validate rat model of empathy for pain, effects pain expressions in a cagemate demonstrator (CD) on responses naïve observer (CO) after 30 min priming dyadic social interactions (PDSI) were evaluated. The CD prepared with four models: bee venom (BV), formalin, complete Freund's adjuvant (CFA), and spared nerve injury (SNI). Both BV formalin tests are characterized by displayable eye-identifiable spontaneous...
Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival social animals. Gastrin-releasing peptide (GRP) its receptor (GRPR) in suprachiasmatic nucleus (SCN) hypothalamus mediates contagious mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual information, independently melanopsin, from to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR relay information paraventricular thalamus (PVT)....
In the mammalian autonomic nervous system, tonic and phasic neurons can be differentiated on firing patterns in response to long depolarizing current pulse. However, similar somatic primary sensory their functional significance are not well investigated. Here, we identified two types of innervating rat dorsal root ganglia (DRG). Tonic fire action potentials (APs) an intensity-dependent manner, whereas typically generate only one AP at onset stimulation regardless intensity. Combining...
Abstract In present study, in vivo electrophysiological techniques were applied to examine the effects of anterior cingulate cortex (ACC) activation on mechanical and electrical stimuli‐evoked responses rat spinal cord wide‐dynamic‐range (WDR) neurons. We found that bilateral ACC stimulation (100 Hz, 20 V, s) had different neuronal brush, pressure pinch stimuli (10 s). The brush‐evoked at baseline, post 1 min 5 60.8±15.0, 59.2±15.4 60.0±19.3 spikes/10 s, respectively ( n =10, P >0.05 vs....
The motor protein Eg5, known as kif11 or kinesin-5, interacts with adjacent microtubules in the mitotic spindle and plays essential roles cell division, yet function of Eg5 mature postmitotic neurons remains largely unknown. In this study, we investigated contribution molecular mechanism pathological pain. Pharmacological inhibition a specific shRNA-expressing viral vector reversed complete Freund's adjuvant (CFA)-induced pain abrogated vanilloid receptor subtype 1 (VR1) expression dorsal...
Acute pressure on the sciatic nerve has recently been reported to provide rapid short-term relief of pain in patients with various pathologies. Wide dynamic range (WDR) neurons transmit nociceptive information from dorsal horn higher brain centers. In present study, we examined effect a 2-min application WDR neuronal activity anesthetized male Sprague-Dawley rats. Experiments were carried out 41 albino rats weighing 160-280 grams. Dorsal identified basis characteristic responses mechanical...
The CXCR2 chemokine receptor is known to have a significant impact on the initiation and control of inflammatory processes. However, its specific involvement in sensation itch not yet fully understood. In this study, we aimed elucidate function trigeminal ganglion (TG) by utilizing orofacial models induced incision, chloroquine (CQ), histamine. Our results revealed up-regulation mRNA protein expressions primary sensory neurons TG response stimuli. inhibitor SB225002 resulted notable decrease...