A5100639685- Pain Mechanisms and Treatments
- Healthcare and Venom Research
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Stroke Rehabilitation and Recovery
- Developmental Biology and Gene Regulation
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Biological and pharmacological studies of plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacogenetics and Drug Metabolism
- Analytical Methods in Pharmaceuticals
- TGF-β signaling in diseases
- Nerve injury and regeneration
- Bee Products Chemical Analysis
- Pain Management and Placebo Effect
- Sesquiterpenes and Asteraceae Studies
- Spinal Cord Injury Research
- Ion channel regulation and function
- Heterotopic Ossification and Related Conditions
- Alkaline Phosphatase Research Studies
Air Force Medical University
2016-2025
Wenzhou Medical University
2020-2024
Nanjing Medical University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2024
Mianyang Third People's Hospital
2023
Xijing Hospital
2012-2022
Xinjiang Medical University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2020
Tianjin Medical University
2020
First Hospital of Xi'an
2020
Dental pulp regeneration by tooth stem cells promotes recovery of damaged teeth in animal models and human patients.
Empathy for the pain experience of others can lead to activation pain-related brain areas and even induce aberrant responses in human observers. Recent evidence shows this high-level emotional cognitive process also exists lower animals; however, mechanisms underlying phenomenon remain unknown. In present study we found that, after social interaction with a rat that had received subcutaneous injection bee venom (BV), only cagemate observer (CO) but not noncagemate (NCO) showed bilateral...
Painful diabetic neuropathy is a common complication of diabetes mellitus and can affect many aspects life severely limit patients' daily functions. Signals painful are believed to originate in the peripheral nervous system. However, its mechanism hyperalgesia has remained elusive. Numerous studies have accumulated that polymodal nociceptive C-fibres play crucial role generation conduction pain signals sensitization which following injury or inflammation leads marked hyperalgesia....
In normal liver, lipocytes are the principal reservoir for retinoids, which stored as retinyl esters. liver injury, activate into myofibroblast-like cells, lack retinoid. We examined mechanisms of retinoid loss using a culture model in lipocyte activation is provoked by exposure to Kupffer cell-conditioned medium (KCM) (S.L. Friedman and M. J. P. Arthur, Clin. Invest. 84: 1780-1785, 1989). exposed KCM, there was approximately 11-fold more retinol than untreated without release Both bile...
Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus and adversely affects the patients' quality life. Evidence has accumulated that PDN associated with hyperexcitability peripheral nociceptive primary sensory neurons. However, precise cellular mechanism underlying remains elusive. This may result in lacking effective therapies for treatment PDN. The phenolic glucoside, gastrodin, which main constituent Chinese herbal medicine Gastrodia elata Blume, been widely...
Background The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and the mechanisms underlying development of HCC remain unclear. Notch1 Notch3 may be involved in malignant transformation, although their roles unknown. Materials Methods tissues were stained anti-Notch1 or -Notch3 antibody. migration invasion capacities cells measured transwell cell culture chambers. RT-PCR was used to measure expression mRNA. Additionally, western blot analysis assess protein Notch1,...
Pain is one critical hallmark of inflammatory responses. A large number studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine type 4 (CXCR4) play an important role in immune reaction processes. However, whether how SDF1–CXCR4 signaling involved pain remains unclear. Under the intraplantar (i.pl.) bee venom (BV) injection-induced persistent state, changes SDF1 CXCR4 expression cellular localization rat dorsal root...
Abstract Objectives Central neuropathic pain (CNP) often appears following spinal cord injury (SCI), but current treatments are not always successful. In this study, we evaluated the analgesic effects of repetitive transcranial magnetic stimulation (rTMS) applied over hand area motor cortex in patients with acute CNP after SCI. Methods A total 48 complete or incomplete SCI and participated study were randomized to receive either rTMS (10 Hz, 1,500 stimuli; N = 24) a sham intervention (N for...
Background:Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for chronic intractable neuropathic pain in patients with spinal cord injury (SCI). However, the analgesia-enhancing effects of rTMS on conventional interventions (e.g., medications), and underlying mechanis ms remain poorly understood. Objective:To investigate enhancement analgesia change cortex activation by following SCI. Methods:A double-blind, sham-controlled, clinical trial was performed. Twenty-one...
Stroke is always associated with a difficult functional recovery process. A brain-computer interface (BCI) technology which provides direct connection between the human brain and external devices. The primary aim of this study was to determine whether training BCI-controlled robot can improve functions in patients subacute stroke.Subacute stroke aged 32-68 years course 2 weeks 3 months were randomly assigned BCI group or sham for 4-week course. outcome measures Loewenstein Occupational...
Hepatocellular carcinoma (HCC) is one of the most common human malignancies and also leading cause cancer-related death in world. The mechanisms underlying progression metastasis HCC remain unclear. E3 ubiquitin ligase F-box WD repeat domain-containing 7 (Fbxw7) broadly considered as a tumor suppressor gene. However, role Fbxw7 not clear. To investigate expression biological functions HCC, we examined level using tissue microarray immunohistochemistry. Our data showed that significantly...
As inflammatory and immune responses are involved in pathophysiology of debilitating neuropathic pain, reagents that can modulate these two may have therapeutic potential. Morin, derived from the moraceae family plants, benefits inflammation‐related diseases, but its antinociceptive effects on cancer pain remain elusive. In present study, we investigated morin bone using a rat model, where rats were subject to implantation Walker 256 mammary gland carcinoma cells into tibia. Morin (5–20...
Central poststroke pain (CPSP) develops commonly after stroke, which impairs the quality of life, mood, and social functioning. Current pharmacological approaches for treatment CPSP are not satisfactory. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique has been recommended chronic CPSP. However, few studies have evaluated analgesic effects rTMS in patients with acute neuropathic stroke. We applied over upper extremity area motor cortex (M1) Forty were randomized...
Neuropathic pain can occur during the prediabetic stage, even in absence of hyperglycemia. The presence neuropathic (PDNP) poses challenges to management individuals with prediabetes. However, mechanisms underlying this remain unclear. This study aims investigate mechanism and identify potential therapeutic targets PDNP. A animal model induced by a high-energy diet exhibits both mechanical allodynia thermal hyperalgesia. Furthermore, hyperexcitability decreased potassium currents are...