A5101421064- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Cell death mechanisms and regulation
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Intracranial Aneurysms: Treatment and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Disorders and Treatments
- RNA modifications and cancer
- Immune Response and Inflammation
- Meningioma and schwannoma management
- Cardiac Ischemia and Reperfusion
- HIV, Drug Use, Sexual Risk
- Alzheimer's disease research and treatments
- Flavonoids in Medical Research
- Mycorrhizal Fungi and Plant Interactions
- Aquaculture disease management and microbiota
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac electrophysiology and arrhythmias
- Cholinesterase and Neurodegenerative Diseases
Air Force Medical University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2003-2023
Hebei Medical University
2022-2023
Second Hospital of Hebei Medical University
2022-2023
Nanjing Medical University
2010-2023
South China Agricultural University
2022
University of Bern
2015-2021
University Hospital of Bern
2021
Weatherford College
2021
Marshall University
2019
Chrysin, an active natural bioflavonoid, has been proven to protect against carcinogenesis. However, the role of chrysin in glioblastoma and potential molecular mechanisms remain be elucidated. In our previous study, we found that nuclear factor erythroid 2 (NF-E2)-related (Nrf2) is highly expressed a variety cell lines associated with mitogen-activated protein kinase (MAPK) pathway. The aim this study was evaluate antitumor effects cells how related MAPK/Nrf2 signaling pathway.A Cell...
The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are still a matter scientific dispute. Here, we aim to characterize possible role receptor‐interacting protein kinase 3 (RIPK3) and mixed lineage domain‐like (MLKL) signaling pathway, which known cause necroptosis, NET formation. Using genetic pharmacological approaches, investigated whether this programmed form necrosis prerequisite NETs...
Abstract Apoptosis is the most common form of neutrophil death under both physiological and inflammatory conditions. However, forms nonapoptotic have also been observed. In current study, we report that human neutrophils undergo necroptosis after exposure to GM-CSF followed by ligation adhesion receptors such as CD44, CD11b, CD18, or CD15. Using a pharmacological approach, demonstrate presence receptor-interacting protein kinase-3 (RIPK3)—a mixed lineage kinase–like (MLKL) signaling pathway...
The objective of this study was to evaluate the immunomodulatory effects cinobufagin (CBG) isolated from Chan Su (Venenum Bufonis) in vitro. In paper, our results show that CBG significantly stimulated cell proliferation splenocytes and peritoneal macrophages (PMΦ) markedly enhanced phagocytic activation PMΦ. also increased CD4(+)CD8(+) double-positive T-cell populations percentage S-phase cells splenic lymphocytes. levels several Th1 cytokines, including interferon-γ tumor necrosis...
Abstract Potassium channel dysfunction has been implicated in Alzheimer's disease (AD). In the present study, by using potassium blocker tetraethylammonium (TEA), we investigated relationship between enhancement of currents and alteration apoptotic cascade neuronal model induced beta‐amyloid peptide 1‐40(Aβ 1–40 ). Cortical neurons exposed to Aβ 5 μM developed a specific increase delayed rectifier current ( I K ), but not transient outward A before appearance apoptosis. various features such...
To elucidate the expression and identify functional changes of 2 pore domain potassium channel TREK-1 during cardiac hypertrophy in rats, left ventricular was induced by subcutaneous injection with isoproterenol. Western blot used to detect protein, inside-out whole-cell recordings were record currents. The results showed that protein endocardium slightly higher than epicardium control ventricles. However, it obviously upregulated 89.8% hypertrophy, 2.3-fold epicardium. Mechanical stretch,...
Background In China, the HIV/AIDS epidemic is expanding among men who have sex with (MSM). As independent risk factors of HIV infection, epidemics Chlamydia (CT) and Gonorrhea (NG) in MSM were not well studied, particular for these infectious. The objectives current reported study to understand dynamics other sexual transmitted infections (STIs) Jiangsu, measure that correlated STIs. Methods order gain more participants, a multisite cross-sectional design was used our study, by using...
Objective(s) To estimate the prevalence of sexually transmitted infections (STIs) among female sex workers (FSWs) in Jiangsu Province, China and measure association Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) with their potential correlates. Design A cross-sectional study on a representative sample FSWs Yangzhou Changzhou cities was conducted. Methods 185 sex-work venues 174 were selected by stratified random sampling. 2972 (1108 1864 Changzhou), aged 15 years or more, who agreed...
Abstract Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide evidence for potential role serine proteases in CD44-mediated GM-CSF–primed human neutrophils. Specifically, observed that several inhibitors known to block enzymatic function fibroblast activation protein-α (FAP-α) were able reactive...
Abstract Background Microglia are important immune cells, which can be induced by lipopolysaccharide (LPS) into M1 phenotype that express pro-inflammatory cytokines. Some studies have shown microRNAs play critical roles in microglial activation. Objective This study was designed to investigate the role of miR-200c-3p regulating inflammatory responses LPS-treated BV2 cells. Methods The expression cells detected real-time PCR. Receptor-interacting protein 2 (RIP2) predicted as a target gene...