A5012873551- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Developmental Biology and Gene Regulation
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Caveolin-1 and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Cell Adhesion Molecules Research
- Liver physiology and pathology
Shanghai First People's Hospital
2014-2025
Shanghai Jiao Tong University
2014-2025
Kashi University
2016
Shandong Provincial QianFoShan Hospital
2011
General Department of Preventive Medicine
2011
Yuhuangding Hospital
2008
Qingdao University
2008
National Natural Science Foundation of China
2008
Huaian First People’s Hospital
2002
Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate biological function clinical significance human colon cancer. We analyzed the expression of TIMP1 both public database (Oncomine TCGA) 94 cases primary cancer matched normal tissue specimens. The underlying mechanisms altered on cell tumorigenesis, proliferation, metastasis were explored vitro vivo. was...
We previously discovered that Ras association domain family member 6 (RASSF6) was downregulated and predicted poor prognosis in GC patients. However, the mechanisms of down regulation RASSF6 remained unclear. Increasing evidence indicates dysregulation microRNAs promotes progression cancer through repression tumour suppressors. Here, we identified miR-181a-5p as a novel regulator GC. Functionally, ectopic expression or silencing miR-181a-5p, respectively, promoted inhibited cell...
Homeobox A10 (HOXA10) belongs to the HOX gene family, which plays an essential role in embryonic development and tumor progression. We previously demonstrated that HOXA10 was significantly upregulated gastric cancer (GC) promoted GC cell proliferation. This study designed investigate of metastasis explore underlying mechanism.Immunohistochemistry (IHC) used evaluate expression GC. In vitro migration invasion assays as well vivo mice metastatic models were utilized effects on metastasis....
Colorectal cancer (CRC) is the second leading cause of death worldwide, and immune checkpoint blockade therapy provides an opportunity for improving outcome CRC patients. Recent studies suggest that programmed ligand-1 (PD-L1) only expressed in 12% CRCs. Here, we demonstrate PD-L2 approximately 40% CRCs, its expression independently associates with poor survival By detection by immunofluorescence 124 cases 10-y data, found significant association between overexpression cells worse overall...
HOXA1 is a member of the Homeobox gene family, which encodes group highly conserved transcription factors that are important in embryonic development. However, it has been reported exhibits oncogenic properties many malignancies. This study focused on expression and clinical significance gastric cancer (GC). To assess mRNA protein cyclin D1 GC tissues, we utilized qRT-PCR western blotting, respectively. The effects cell proliferation, migration, invasion, as well xenograft tumor formation...
Biglycan, a member of the small leucine-rich proteoglycan family, has been implicated in development and progression human cancers. However, clinical significance biglycan expression gastric cancer not determined. In present study, mRNA protein concentrations were analyzed using quantitative realtime reverse transcription polymerase chain reaction Western blot 69 adjacent non-tumorous tissues, respectively. Biglycan was further assessed immunohistochemistry tissue microarrays that contained...
Abstract Homeobox A10 (HOXA10) has been implicated critical for the promotion of carcinogenesis, but underlying mechanism between HOXA10 and malignant gastric cancer (GC) phenotype remains elusive. In present study, we analyzed validated that BCL2 expressions were elevated both at mRNA protein levels in GC tissues. Upregulated promoted cell proliferation with reduced apoptosis vitro accelerated tumor growth vivo. Bioinformatics analysis quantitative real‐time polymerase chain reaction...
While simulation is widely employed in anesthesia crisis management training, its effectiveness often hindered by lack of preparation. Flipped classroom (FC) a novel teaching method that encourages active student engagement and We aim to investigate whether FC could enhance the residents' preparation activities improve learning outcomes simulation. This quasi-experimental study included anesthesiology residents from department, Shanghai General Hospital between January 2023 July 2023. The...
Backgrouds: Whether homologous recombination repair (HRR) mutation has a differential effect on the prognosis not been confirmed by current studies. The purpose of this study was to explore clinical importance, prognostic value, and frequency pathogenic changes in HRR genes patients with ovarian cancer (OC). Methods: We analyze information including OC both our cohort TCGA-OV database. Blood and/or tumor samples from 98 women admitted Shanghai General Hospital between January 2021 May 2024,...
Abnormal activation of the hedgehog (Hh) signaling pathway has been found to be involved in occurrence, invasion, and metastasis cancers. Epithelial-mesenchymal transition (EMT) also plays an important role invasion However, significance Hh EMT gastric cancer is still unclear. This study aimed investigate prognostic value progressive cancer. Immunohistochemistry was performed detect expression Hh-induced transcriptional factor Gli-1 EMT-related molecules Snail E-cadherin 121 patients with...
Increasing evidence has found that the dysregulation of long non-coding RNAs (lncRNAs) may be important indicators in tumorigenesis. MYC-induced RNA (MINCR) been to related with some cancers, such as non-small cell lung cancer and gallbladder cancer. Besides, MINCR potentially prognostic value for colon (CC) patients' prognosis, yet its function molecular mechanism CC are not explored. qRT-PCR evaluated gene expression, western blot detected protein level. In vitro vivo experiments were...
MicroRNAs (miRNAs) are important regulators of gastric cancer development and progression. miR-148a is one the most frequently highly downregulated miRNAs in associated with advanced clinical stage poor prognosis. In this study, we investigated role metastasis. Levels were determined by qRT-PCR 60 samples. Cell migration invasion assays performed a stably expressing miRNA-148a cell line established using lentivirus expression system. Epithelial-mesenchymal transition (EMT) was evaluated...
Retinoblastoma binding protein 6 (RBBP6) plays an important role in chaperone-mediated ubiquitination and interacts with TP53 carcinogenesis. However, the clinicopathologic significance of RBBP6 expression colon cancer is unknown; particular, prognostic value combined has not been explored. Therefore, quantitative real-time PCR western blot analyses were performed to detect tissues. assessed by immunohistochemistry a tissue microarray format, which primary was paired noncancerous tissue....
Gastric cancer (GC) is one of the most common cancers causing a poor prognosis worldwide. HOXA13, as member homeobox (HOX) family, involved in regulation progression and has attracted increasing attention, potential novel target for anticancer strategies. However, significance HOXA13 GC remains unclear. This article aims to explore mechanism progression.Quantitative real-time PCR was carried out detect expression FN1 correlation between tissues. In vitro assays were conducted investigate...
Expression microarrays are widely used for investigating the nature and extent of global gene-expression changes in human cancer. Accurate genomewide profiles have not been conducted colon tumor normal tissue specimens obtained from Chinese patients.In present study a pure population cancer cells was differences were compared 2 cell types using combined experimental bioinformatic approaches. Various categories genes that differentially expressed those identified, including novel candidate...