A5003222281- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- CAR-T cell therapy research
- Calpain Protease Function and Regulation
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Inflammatory mediators and NSAID effects
- Colorectal Cancer Treatments and Studies
- Phytoestrogen effects and research
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- interferon and immune responses
- Galectins and Cancer Biology
- Hair Growth and Disorders
- Protein Degradation and Inhibitors
- Synthesis and biological activity
- Menopause: Health Impacts and Treatments
Renji Hospital
2017-2021
Shanghai Jiao Tong University
2017-2021
Fudan University
2021
Yunnan Academy of Agricultural Sciences
2021
State Key Laboratory of Oncogene and Related Genes
2017-2020
Jiangmen Central Hospital
2020
Shanghai Sixth People's Hospital
2018
Shanghai Institute of Hematology
2018
Air Force Medical University
2017
Programmed death-ligand 1 (PD-L1) expression in colorectal cancer (CRC) was implicated predicting anti-PD-1/PD-L1 therapy efficacy. However, therapeutic response has also been found patients without PD-L1 the primary tumor. In present study, we aimed to clarify prevalence of and metastatic CRC.The determined by immunohistochemistry matched CRC.PD-L1 significantly more prevalent CRCs than tumors, CRC may not represent tumors that spread distant organs. Positive 81.8% CRC, being (40.9%; P =...
Colorectal cancer (CRC) is the second leading cause of death worldwide, and immune checkpoint blockade therapy provides an opportunity for improving outcome CRC patients. Recent studies suggest that programmed ligand-1 (PD-L1) only expressed in 12% CRCs. Here, we demonstrate PD-L2 approximately 40% CRCs, its expression independently associates with poor survival By detection by immunofluorescence 124 cases 10-y data, found significant association between overexpression cells worse overall...
We show for the first time that PD-1 is palmitoylated, identify DHHC9 as predominant enzyme its palmitoylation, and reveal molecular mechanisms underlying effects on stability functions. Importantly, we also designed PD1-PALM, a competitive inhibitor of this first-in-class molecule may inspire development new checkpoint inhibitors.
Background The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mechanisms that drive and maintain PD-L1 expression are still incompletely understood. Methods Combined analyses genomes proteomics were applied to find potential regulators PD-L1. In vitro experiments performed investigate regulatory mechanism by thyroid adenoma associated gene (THADA) using human colorectal (CRC) cells. prevalence THADA was...
To explore the correlation of body composition with severity menopausal symptoms, as well each classic symptom.A total 758 (peri-)menopausal women were recruited (aged from 40 to 67 years) Menopause Clinic in Shanghai Sixth People's Hospital. Different regions fat mass, lean mass and fat-free measured by bioelectrical impedance analysis, while symptoms evaluated valid modified Kupperman's index (KMI) Chinese version.After adjusting for potential confounders, logistic regression revealed that...
Gastric acidity-associated disorders such as peptic ulcer and reflux diseases are widespread, the reported resistance side effects of currently used medicines suggest an urgent requirement for alternative therapeutic approaches. Here we demonstrate a critical role ASAP3 in regulating microvilli structure parietal cells vivo , reveal feasibility controlling gastric acidity by targeting ASAP3. Conditional knockout mice caused elongation stacking cells, substantially decreased acid secretion....
Abstract Programmed cell death protein 1 (PD-1) is a crucial anticancer target, but the relatively low response rate and acquired resistance to existing antibody drugs highlight an urgent need develop alternative targeting strategies. Here we report palmitoylation of PD-1, discovered main DHHC enzyme for this modification, revealed mechanism its effect on PD-1 expression, rationally developed peptide expression. Palmitoylation promoted trafficking recycling endosome, thus preventing...
Summary Cancer cell expression of PD-L1 leads to T cells exhaustion by transducing co-inhibitory signal, and further understanding the regulation in cancer may provide additional therapeutic strategies. Here drug repurposing screen we identified amlodipine as a potent inhibitor cells. Further survey calcium-associated pathways revealed calpains-dependent stabilization protein. Intracellular calcium delivered an operational signal calpain-dependent Beclin-1 cleavage, blocking autophagic...
Hereditary properties of strong growth and huge accumulation biomass in Oryza officinalis exhibit a great potential; however, the genes that code for its high photosynthesis performance are not established. This study screened eight hybrids, using analysis, based on introgression lines constructed by analyzing distant hybridization patterns between cultivars HY-8. We designed 23 primer pairs transcriptome sequencing two types photosynthetic enzymes: phosphoenolpyruvate carboxylase (PEPC)...