A5100450168- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Inflammation biomarkers and pathways
- Glaucoma and retinal disorders
- Respiratory Support and Mechanisms
- Cellular transport and secretion
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion Channels and Receptors
- Corneal surgery and disorders
- Regulation of Appetite and Obesity
- Neonatal Respiratory Health Research
- Plant Reproductive Biology
- Tracheal and airway disorders
- Ion channel regulation and function
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Neuroscience of respiration and sleep
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2015-2024
Wuhan Sports University
2024
University of Missouri
2024
West China Hospital of Sichuan University
2012-2024
Zhejiang Chinese Medical University
2023
West China Second University Hospital of Sichuan University
2023
Child Trends
2023
Weatherford College
2023
Air Force Medical University
2022
In plant cells, the endoplasmic reticulum (ER) and Golgi apparatus form a unique system in which single stacks are motile close association with underlying ER tubules. Arabidopsis has three RHD3 (ROOT HAIR DEFECTIVE 3) isoforms that analogous to mammalian atlastin GTPases involved shaping We used live-cell imaging, genetic complementation, split ubiquitin assays western blot analyses tobacco show mediates generation of tubular network is required for distribution motility root leaf epidermal...
Significance Oscillations in the concentration of free cytosolic calcium are an important control mechanism many cell types. However, we still have little understanding how some cells can exhibit oscillations with a period less than second, whereas other hundreds seconds. Here, show that one common type oscillation has dynamic structure is independent period. We thus hypothesize their by varying rate at which critical internal variables move around this and be controlled activates release...
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute induced short-term smoke (CS). However, whether how NETs contribute to sustained remain unclear. This study aimed elucidate the immunoregulatory mechanism of COPD, employing human neutrophils, epithelial cells (AECs), dendritic (DCs), a long-term CS-induced mouse model,...
Cytokinesis and cell polarity are supported by membrane trafficking from the trans-Golgi network (TGN), but molecular mechanisms that promote TGN poorly defined in plant cells. Here we show TRAPPII Arabidopsis regulates post-Golgi is crucial for assembly of plate polarity. Disruptions AtTRS120 or AtTRS130, two genes encoding key subunits TRAPPII, result defective cytokinesis embryogenesis seedling development. In attrs120 attrs130, organization endoplasmic reticulum (ER)-Golgi interface...
Glomerular epithelial cells (GEC) are a known site of vascular endothelial growth factor (VEGF) production. We established immortalized rat GEC, which retained the ability to produce VEGF. The isoforms expressed by GEC were defined as VEGF-205, -188, -120, and -164. electrical resistance cultured on GEC-conditioned matrix, an indicator permeability monolayers solutes, was significantly increased treatment with neutralizing polyclonal antibodies VEGF decreased VEGF-165. Transfection green...
The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor suppressor pathway, functions as an oncoprotein in variety of cancers. However, its contribution to breast cancer remains controversial. This study investigated role YAP cells under nutrient deprivation (ND). Here, we show that knockdown sensitized MCF7 deprivation-induced apoptosis. Furthermore, response ND, increased autolysosome degradation, thereby enhancing cellular autophagic flux cells. Of...
ABSTRACT In this paper, the cold expansion test of titanium alloy open hole structures was conducted, and fatigue performance also assessed. A parametric study mandrel front cone angle revealed a correlation with strengthening quality evolution, providing valuable insight for optimization structure designs. The results showed that resistance decreased then increased increase angle. microhardness edge exhibited obvious sensitivity to As expected, life specimens after strengthening. best 15°....
Introduction: C-X-C motif chemokine 5 is primarily chemotactic for neutrophils and previously shown to increase in the bronchoalveolar lavage fluid of patients with chronic obstructive pulmonary disease. However, whether levels correlate lung function decline or mouse model disease was not clear. Methods: The induced by cigarette smoke exposure. Plasma/serum were obtained from disease; assessed correlated functions granulocyte-colony stimulating factor levels, respectively. Results:...
Abstract Background Fibroproliferative repair starts early in the inflammatory phase of acute respiratory distress syndrome (ARDS) and indicates a poor prognosis. Lumican, small leucine-rich proteoglycan, is implicated homeostasis fibrogenesis, but its role ARDS unclear. Methods Bronchoalveolar lavage fluid (BALF) samples were obtained from patients (n = 55) enrolled within 24 h diagnosis mechanically ventilated 20) spontaneously breathing 29) control subjects. Lipopolysaccharide...
Summary 1. Nitric oxide (NO), a gas transmitter, modulates many physiological processes, including the central regulation of cardiovascular activity. However, mechanisms underlying activity remain relatively unexplored. In present study, we hypothesized that NO-dependent sympathetic inhibition is mediated by activation adenosine A2A receptors (A2AR) and acetylcholine (ACh) release in rostral ventrolateral medulla (RVLM). 2. l-Arginine (l-Arg; an NO donor; 100 nmol/100 nL) was microinjected...
Chronic obstructive pulmonary disease (COPD) is an important public health challenge worldwide, and usually caused by significant exposure to noxious agents, particularly cigarette smoke. Recent studies have revealed that excessive production of neutrophil extracellular traps (NETs) in the airways associated with severity COPD patients. NETs are neutrophil-derived structures composed chromatin fibers decorated histones granule proteases including elastase (NE). However, effective prevention...
Myofascial Pain Syndrome (MPS) is a prevalent disease, and the related literature research has been increasing in recent years. However, there lack of scientific comprehensive bibliometric analyses MPS field. This study aimed to summarize visualize distribution laws, hotspots development trends based on methods. Relevant from 1956 2022 was retrieved Web Science Core Collection database. Quantitative visual collected were performed using Microsoft Office 2021, Bibliometrics, VOSviewer,...
The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic adrenal (HPA) axis activation was tested by examining effect pharmacologic VP receptor blockade on adrenocorticotropic hormone (ACTH) and corticosterone responses 14‐day repeatedly restrained rats. In spite increased vasopressinergic activity, rats showed lower ACTH to 10 min white noise compared with handled controls. These were unchanged injection...
Abstract Acute lung injury (ALI) is a severe disease with sudden onset, rapid progression, poor treatment response, and high mortality. An increasing number of studies had found that circular RNAs (circRNAs) has significant functions in various diseases, while the role circRNAs ALI not yet clear. The purpose this study was to find related their mechanism action. Expression profiles messenger (mRNAs) were analyzed by microarray mice models healthy controlled mice. Differentially expressed...
Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival social animals. Gastrin-releasing peptide (GRP) its receptor (GRPR) in suprachiasmatic nucleus (SCN) hypothalamus mediates contagious mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual information, independently melanopsin, from to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR relay information paraventricular thalamus (PVT)....