A5065796750- Natural product bioactivities and synthesis
- Hedgehog Signaling Pathway Studies
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Phytochemistry and Bioactive Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Phytochemical compounds biological activities
- RNA modifications and cancer
- High voltage insulation and dielectric phenomena
- Alzheimer's disease research and treatments
- Phytochemistry and Biological Activities
- Neural and Behavioral Psychology Studies
- Satellite Communication Systems
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Aerosol Filtration and Electrostatic Precipitation
- Phytochemistry and Bioactivity Studies
- EEG and Brain-Computer Interfaces
- Cancer Mechanisms and Therapy
- Medicinal Plants and Neuroprotection
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
Hangzhou Medical College
2020-2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2017-2025
Soochow University
2012-2025
First Affiliated Hospital of Soochow University
2025
Nanjing University of Science and Technology
2025
Sichuan University
2019-2024
Zhejiang University
2008-2024
Guangxi Normal University
2023-2024
West China Hospital of Sichuan University
2019-2024
WuXi AppTec (China)
2024
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute induced short-term smoke (CS). However, whether how NETs contribute to sustained remain unclear. This study aimed elucidate the immunoregulatory mechanism of COPD, employing human neutrophils, epithelial cells (AECs), dendritic (DCs), a long-term CS-induced mouse model,...
Chlorogenic acid (CGA), a phenolic isolated from fruits and vegetables, has been established to have neuroprotective properties in relation Alzheimer's disease (AD). However, the precise mechanism by which CGA prevents cognitive deficits AD not well studied. This study aimed explore potential molecular of action using an Aβ25-35-induced SH-SY5Y neuron injury cogxnitive model APP/PS1 mice.Three-month-old male double transgenic mice human neuroblastoma cell line (SH-SY5Y) were used assess...
Purpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC). Methods: The constituents QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). therapeutic impacts assessed in dextran sulfate sodium (DSS)-induced UC mice, focusing changes body weight, disease activity index (DAI), colon length, histological assessment colonic tissues, levels pro-inflammatory...
Metabolomics has been shown to be an effective tool for biomarker screening and pathway characterization disease diagnosis. Metabolic characteristics of hepatocellular carcinoma (HCC) may enable the discovery novel biomarkers its In this work, metabolomics was used investigate metabolic alterations HCC patients. Plasma samples from patients age-matched healthy controls were investigated using high resolution ultrahigh performance liquid chromatography-mass spectrometry differences analyzed...
The incidence of Ulcerative colitis (UC), a key form inflammatory bowel disease (IBD) affecting the rectum and colon, is increasing globally. advancement in microbiome metabolomics research has revealed crucial involvement intestinal microbiota pathogenesis progression UC. Chinese herbal medicines, characterized by structural diversity multiple pharmacological activities, consistently serve as vital sources for developing anti-UC drugs. In this review, we searched focused on several online...
Prostate cancer (PCa) is the second leading cause of death among men and associated with profound metabolic changes.
Abstract As a novel kind of non‐coding RNA, circular RNAs (circRNAs) were involved in various biological processes. However, the role circRNAs developmental process chronic obstructive pulmonary disease (COPD) is still unclear. In present study, by using cell model COPD primary human small airway epithelial cells (HSAECs) treated with or without cigarette smoke extract (CSE), we uncovered 4,379 previously unknown and 903 smoke‐specific circRNAs, help RNA‐sequencing bioinformatic analysis....
Abstract Background Fibroproliferative repair starts early in the inflammatory phase of acute respiratory distress syndrome (ARDS) and indicates a poor prognosis. Lumican, small leucine-rich proteoglycan, is implicated homeostasis fibrogenesis, but its role ARDS unclear. Methods Bronchoalveolar lavage fluid (BALF) samples were obtained from patients (n = 55) enrolled within 24 h diagnosis mechanically ventilated 20) spontaneously breathing 29) control subjects. Lipopolysaccharide...
Quzhou Aurantii Fructus (QAF), the dried immature fruit of Citrus changshan-huyou Y.B. Chang, is similar to (AF), aurantium L. or its cultivars, in terms composition, pharmacological action, and appearance. However, potential chemical markers distinguish QAF from AF remain unknown owing lack a comprehensive systematic comparison aligned with discriminant analysis. To achieve better understanding differences their this study aimed identify basic compounds (n = 42) 8) using ultra-performance...
T-cell receptors (TCRs) play a pivotal role in the adaptive immune system, and understanding their antigen recognition mechanism remains critical area of research. With increasing availability binding interaction data between TCRs peptide-major histocompatibility complexes (pMHCs), data-driven computational methods are emerging as powerful tools with significant potential for advancement. In this study, we collected curated comprehensive sequence structure sets from human CD8+ T-cells...
The injection and accumulation of space charge in the bulk XLPE insulation will be intensified due to ageing HVDC cable which affect normal operation cable. In this paper, effects thermal stress different endurance time temperature on distribution were studied. samples used tests all slices 160 kV DC temperatures 90 135 °C, represented low high stress, respectively. Pulsed Electro-Acoustic (PEA) method was measure decay characteristics samples. And then, electron trap properties test...
This study investigated whether the mitochondrial‐targeted peptide SS‐31 can protect against cigarette smoke‐ (CS‐) induced airway inflammation and oxidative stress in vitro vivo . Mice were exposed to CS for 4 weeks establish a CS‐induced model, those experimental group pretreated with 1 h before exposure. Pathologic changes lung tissue, inflammatory cell counts, proinflammatory cytokine levels bronchoalveolar lavage fluid (BALF) examined. The mechanistic basis effects of on extract‐ (CSE‐)...
Importance The optimal treatment for and potential benefit populations of synchronous oligometastatic esophageal squamous cell carcinoma (SOESCC) remain unclear. Objectives To evaluate outcomes concurrent chemoradiotherapy (CCRT) to construct decision tree models predicting the risk progression mortality in patients with SOESCC. Design, Setting, Participants This prognostic study included 532 SOESCC who were treated at 2 cancer centers China from January 2012 December 2018 consisted a...
Chronic obstructive pulmonary disease (COPD) is an important public health challenge worldwide, and usually caused by significant exposure to noxious agents, particularly cigarette smoke. Recent studies have revealed that excessive production of neutrophil extracellular traps (NETs) in the airways associated with severity COPD patients. NETs are neutrophil-derived structures composed chromatin fibers decorated histones granule proteases including elastase (NE). However, effective prevention...