A5100333420- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Kidney Stones and Urolithiasis Treatments
- Adipose Tissue and Metabolism
- Systemic Sclerosis and Related Diseases
- Silk-based biomaterials and applications
- Temporomandibular Joint Disorders
- Mast cells and histamine
- Periodontal Regeneration and Treatments
- Olfactory and Sensory Function Studies
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Systemic Lupus Erythematosus Research
- Respiratory and Cough-Related Research
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- Medicinal plant effects and applications
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Flame retardant materials and properties
- Cervical Cancer and HPV Research
- Berberine and alkaloids research
- Medicinal Plants and Bioactive Compounds
Shandong University
2017-2024
Sichuan University
2003-2024
Wenzhou Medical University
2022-2024
Ruian People's Hospital
2022-2024
Shanghai Institute of Ceramics
2017-2023
Chinese Academy of Sciences
2017-2023
University of Nottingham Ningbo China
2023
Tianjin Medical University Cancer Institute and Hospital
2019-2022
Shanghai Jiao Tong University
2020
Tongji University
2020
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute induced short-term smoke (CS). However, whether how NETs contribute to sustained remain unclear. This study aimed elucidate the immunoregulatory mechanism of COPD, employing human neutrophils, epithelial cells (AECs), dendritic (DCs), a long-term CS-induced mouse model,...
Abstract Background Due to the lack of research on pathological mechanism temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in clinic. In recent years, microRNAs (miRs) have been demonstrated play an important role pathogenesis (OA) by regulating a variety target genes, and latest evidence shows that miR-21-5p is specifically overexpressed OA. The purpose this project was clarify whether can regulate TMJOA process targeting Spry1. Methods induced...
The repair of damaged cartilage still remains a great challenge in clinic. It is demonstrated that bone marrow stromal cells (BMSCs)-chondrocytes communication significance for repair. Moreover, BMSCs have been confirmed to enhance biological function chondrocytes via exosome-mediated paracrine pathway. Lithium-containing scaffolds reported effectively promote regeneration; however, whether lithium-containing biomaterial could facilitate regeneration through regulating BMSCs-derived exosomes...
Airway inflammation with mucus overproduction is a distinguishing pathophysiological feature of many chronic respiratory diseases. Phosphodiesterase (PDE) inhibitors have shown anti-inflammatory properties. In the present study, effect sildenafil, potent inhibitor PDE5 that selectively degrades cyclic guanosine 3′,5′-monophosphate (cGMP), on acrolein-induced and production in rat airways was examined. Rats were exposed to acrolein for 14 28 days. Sildenafil or distilled saline administered...
Background/Aims: Osteoarthritis (OA) as a degenerative disease is major problem in ageing populations. To better understand the molecular mechanisms pathogenesis of OA, this study explored role microRNA (miR)-146a articular chondrocytes. Methods: The chondrocyte line ATDC5 was used to simulate inflammatory injury by LPS administration vitro. Cell viability, apoptosis, mRNA expressions and productions factors were assessed, respectively. Mir-146a Cxcr4 measured qRT-PCR. Targeting effect...
LCS scaffolds promoted chondrocyte maturation by inducing M2 macrophage polarization.
The aim of the study was to explore relationship between concentration C-telopeptide fragments type II collagen (CTX-II), Zn2+, and Ca2+ in urine knee osteoarthritis (KOA). Eighty-two patients with KOA 20 healthy volunteers were enrolled. Anteroposterior lateral position x-rays joints collected. images classified according Kellgren-Lawrence radiographic grading criterion. divided into group grade I, II, III, IV. CTX-II detected by enzyme-linked immunosorbent assay. Zn2+ inductively coupled...
Aims The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). Methods TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) a unilateral anterior crossbite (UAC) procedure. Mouse tissues exhibited histopathological changes, as assessed by: Safranin O, toluidine blue, immunohistochemistry staining; western blotting (WB); quantitative real-time polymerase chain...
Abstract Objective This study aimed to provide support for the extensive application of Distress Thermometer (DT) in advanced cancer inpatients with pain and explored factors associated high DT scores among this population. Methods Advanced patients were recruited from Department Pain Relief Tianjin Cancer Hospital Institute, China. They completed problems list HADS within 48 h after admission. The cutoff score was evaluated against Anxiety Depression Scale (HADS) its sensitivity specificity...
The present study investigated the molecular changes and related regulatory mechanisms in response of skeletal muscle to exercise. microarray dataset 'GSE109657' high‑intensity intermittent exercise training (HIIT) was downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened analyzed using weighted gene co‑expression network analysis (WGCNA) identify significant functional co‑expressed modules. Moreover, enrichment performed for DEGs In addition,...
Temporomandibular disorders are a common cause of chronic pain in the orofacial region and have complex multi-factorial pathophysiology. Mechanical loading or inflammatory conditions been shown to decrease oxygen tension within joint cartilage activate hypoxia-inducible factor (HIF) pathway, which turn aggravates pathological processes underlying temporomandibular (TMJ) disorders. We previously showed that low-intensity pulsed ultrasound (LIPUS) treatment effectively repairs TMJ injury...
Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and obstructive pulmonary disease. AMH contributes to the pathogenesis diseases, it associated with reduced lung function high rates hospitalization mortality. It has been suggested that should be target in treatment diseases. Recent evidence suggests regulator inflammation, hyperresponsiveness, remodeling peroxisome proliferator-activated...
The objective of the current study was to investigate ability human umbilical cord blood‑derived mesenchymal stem cells (HUCB‑MSCs) undergo chondrogenic differentiation, by co‑culture with rabbit chondrocytes. aim obtain more seed for tissue engineering research and lay foundation clinical repair cartilage defects. studies were performed using isolated HUCB‑MSCs in vitro, which co‑cultured a 2:1 or 3:1 ratio without insulin‑like growth factor‑1 (IGF‑1). Following 7 14 days culture, cell...