A5048575345- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Osteoarthritis Treatment and Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tendon Structure and Treatment
- Cancer Immunotherapy and Biomarkers
- Microtubule and mitosis dynamics
- Inflammatory mediators and NSAID effects
- Liver physiology and pathology
- Shoulder Injury and Treatment
- Natural product bioactivities and synthesis
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Laser Applications in Dentistry and Medicine
- Polysaccharides Composition and Applications
- Adolescent and Pediatric Healthcare
- Veterinary Equine Medical Research
- Cancer Mechanisms and Therapy
- Silk-based biomaterials and applications
- Endoplasmic Reticulum Stress and Disease
- Proteoglycans and glycosaminoglycans research
- Bone Metabolism and Diseases
- Orthopedic Surgery and Rehabilitation
- Flavonoids in Medical Research
Central South University
2019-2024
Xiangya Hospital Central South University
2019-2024
Creative Commons
2023
Bryan College
2022
Texas A&M University
2022
Soil and Fertilizer Institute of Hunan Province
2019
Shandong Academy of Pharmaceutical Sciences
2012-2019
Shandong University
2017-2018
First Affiliated Hospital of Harbin Medical University
2018
Harbin Medical University
2018
Functional fibrocartilage regeneration is a bottleneck during bone-tendon healing, and the currently available tissue-engineering strategies for are insufficient because of lack appropriate scaffold that can load large seeding-cells induce chondrogenesis stem cells. The acellular (AFS) contains active growth factors as well tissue-specific epitopes cell-matrix interactions, which make it potential tissue-engineered fibrocartilage. A limitation to this its low porosity inhibits cells loading...
Osteoarthritis (OA) is a degenerative joint disease and major cause of pain disability in older adults. We have previously identified epidermal growth factor receptor (EGFR) signaling as an important regulator cartilage matrix degradation during epiphyseal development. To study its function OA progression, we performed surgical destabilization the medial meniscus (DMM) to induce two mouse models with reduced EGFR activity, one genetic modification (Egfr(Wa5/+) mice) other pharmacological...
To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC).In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240 mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3), or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue progression-free survival (PFS) as primary for 1/2.A...
Purpose Early prediction of the prognosis viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim this study to explore a comprehensive prognostic assessment model evaluating survival outcomes post-TIPS.
Osteoarthritis (OA) is a multifactorial disease that associated with inflammation in joints. The purpose of the present study was to investigate anti-inflammatory activity and mechanism morin on human osteoarthritis chondrocytes stimulated by IL-1β.The levels NO PGE2 were measured Griess method ELISA. MMP1, MMP3, MMP13 also ELISA.The results revealed IL-1β significantly increased production NO, PGE2, MMP13. Additionally, increases attenuated treatment morin. Furthermore, IL-1β-induced NF-κB...
Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells vitro. This study aimed to determine whether LIPUS improve the efficacy transplanted on B-T healing.LIPUS lineage-specific adipose-derived (ASCs) at site, thus resulting superior quality when compared with ASCs alone.Controlled laboratory study.A total 112 mature rabbits partial patellectomy...
Objective The aim of the study was to evaluate dosage effect low-intensity pulsed ultrasound stimulation on tendon-bone healing. Design Standard partial patellectomies were performed 120 mature New Zealand rabbits randomly assigned into following three groups: a control group (daily mock sonication, 20 mins), qd ultrasonication, and bid (ultrasonication twice day, mins each time). killed 8 or 16 wks postoperatively, microarchitectural, histological, mechanical properties patella-patellar...
Bone-tendon (B-T) healing is a clinical challenge due to its limited regeneration capability. Fibrocartilage and bone formation at the site are two critical factors for B-T healing. Promoting fibrocartilage by tissue-engineering may be promising treatment strategy. In this study, we innovatively fabricated kinds of acellular scaffolds from or tissues, namely book-type scaffold (BABS) (BAFS). Histologically, well preserved native extracellular matrix (ECM) structure without cellular...
We previously reported that intra-articular injection of xanthan gum protected the joint cartilage and reduced osteoarthritis progression. In this study, effects on chondrocytes apoptosis were evaluated using labeling assay, terminal deoxynucleotidyl transferase-mediated dUTP nick end to determine protein expression matrix metalloproteinase-1, 3, tissue inhibitors metalloproteinase-1 immunohistochemistry Western blot assay in papain-induced rabbit model. Compared negative control group, gum,...
<p>Supplementary Method, Table 1-9</p>
<p>Supplementary Fig. 4 A. Progression-free survival by PD-L1 status. B. Overall Dot marks indicate censored data.</p>
<p>Supplementary Fig. 3 A. Progression-free survival by CD8+ TIL density. B. Overall Dot marks indicate censored data.</p>
<p>Supplementary Fig. 1 Forest plot of subgroup analysis for progression-free survival (A) and overall (B).</p>
<p>Supplementary Fig. 2 The association of CD8+ TIL density and PD-L1 expression with tumor objective response.</p>
<div>Abstract<p>Purpose: To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC). Patients Methods: In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3) or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue...
<p>Supplementary Method, Table 1-9</p>
<p>Supplementary Fig. 1 Forest plot of subgroup analysis for progression-free survival (A) and overall (B).</p>