A5100441500- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Voice and Speech Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Silk-based biomaterials and applications
- NF-κB Signaling Pathways
- Gallbladder and Bile Duct Disorders
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Metal-Organic Frameworks: Synthesis and Applications
- Flavonoids in Medical Research
- Nuclear Receptors and Signaling
- Cancer Immunotherapy and Biomarkers
- Inorganic Chemistry and Materials
- Hypertrophic osteoarthropathy and related conditions
- Medicinal plant effects and applications
- Quantum-Dot Cellular Automata
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Wireless Signal Modulation Classification
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
Chinese Academy of Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2024
Shenzhen Institutes of Advanced Technology
2024
National Engineering Research Center of Electromagnetic Radiation Control Materials
2024
Nanfang Hospital
2024
Zhuzhou Central Hospital
2022-2024
Central South University
2024
Beijing National Laboratory for Molecular Sciences
2024
Institute of Chemistry
2024
Southern Medical University
2024
The treatment of cartilage lesions has always been a difficult problem. Although tissue engineering provides alternative options for lesions, biodegradable scaffolds have limitations.In this study, we constructed porous PEEK scaffold via 3D printing, surface-engineered with concentrated sulfuric acid 15 s (SPK-15), 30 (SPK-30), and 60 (SPK-60). We systematically evaluated the physical chemical characteristics biofunctionalities scaffolds, then macrophage polarization modulating ability...
ObjectiveTo investigate microRNA (miRNA) expression profiles in the seminal plasma of nonobstructive azoospermia (NOA) patients with different histopathologic patterns and evaluate potential noninvasive diagnostic biomarkers NOA.DesignSequencing validation using quantitative reverse transcription polymerase chain reaction (qRT-PCR).SettingReproductive center research institute.Patient(s)Thirteen NOA (7 Sertoli cell–only syndrome [SCOS] 6 hypospermatogenesis to spermatogenesis arrest [SA]) 7...
This study aimed to assess the safety and efficacy of percutaneous transhepatic cholangiography drainage (PTCD) endoscopic retrograde cholangiopancreatography (ERCP) in palliative preoperative biliary for treating malignant obstructive jaundice (MOJ). A total 520 patients with MOJ who underwent PTCD or ERCP were enrolled classified into group group. Baseline characteristics, liver function, blood routine, complications compared among groups. The technical success rates 97.1% 85.9%. In group,...
Inflammatory cytokines commonly initiate extreme changes in the synovium and cartilage microenvironment of osteoarthritis (OA) patients, which subsequently cause cellular dysfunction, especially chondrocytes. It has been reported that induction purinergic P2X7 receptor (P2X7R) can regulate expression a variety inflammatory factors, including interleukin (IL)-6 -8, leading to OA pathogenesis. However, knowledge mechanism upregulation P2X7R is still incomplete, its role chondrocyte...
In tissue engineering, hydrogel scaffolds allow various cells to be cultured and grown in vitro then implanted repair or replace the damaged areas. Here this work, kartogenin (KGN), an effectively chondro-inductive non-protein bioactive drug molecule, was incorporated into a composite comprising positively charged chitosan (CS) methacrylated gelatin (GelMA) polymers fabricate appropriate microenvironments of bone marrow mesenchymal stem (BMSCs) for cartilage regeneration. Based on...
Background: Osteoarthritis (OA) is a degenerative joint disease that acts as major cause of early disability in the old population. However, molecular mechanisms autophagy osteoclasts involved OA remain unclear. Methods: The gene expression profiles were downloaded from Gene Expression Omnibus (GEO) repository. NCBI GEO2R and ScanGEO analysis tool used to identify differentially expressed genes (DEGs). protein-protein interaction (PPI) network was predicted by STRING website visualized with...
Bone marrow mesenchymal stem cell (BMSC) chondrogenic differentiation contributes to the treatment of osteoarthritis (OA). Numerous studies have indicated that microRNAs (miRNAs) regulate pathogenesis and development multiple disorders, including OA. Nevertheless, role miR-20a-5p in OA remains obscure. Forty male C57BL/6 mice were divided into four groups surgically induced or underwent sham surgery presence absence miR-20a-5p. Flow cytometry was implemented detect surface markers BMSCs....
Vocal fold leukoplakia (VFL) is a precancerous lesion of laryngeal cancer, and its endoscopic diagnosis poses challenges. We aim to develop an artificial intelligence (AI) model using white light imaging (WLI) narrow-band (NBI) distinguish benign from malignant VFL.
To evaluate the outcomes of vulvar reconstruction using anterolateral thigh (ALT) flaps in patients with advanced and recurrent malignancies.Totally 24 who received ALT-based were retrospectively reviewed to outcome focusing on quality life prognosis.Four at time primary surgery due stage, 20 underwent after recurrence. No patient experienced complete flap loss. Major complications happened five (20.83%). Minor occurred three (12.5%). All wounds healed favorable appropriate treatment. The...
Introduction Limited clinical studies have been conducted on rare solid tumours, and there are few guidelines the diagnosis treatment, including experiences with targeted therapy immunotherapy, of tumours in China, resulting limited treatment options poor outcomes. This study first proposes a definition is designed to test preliminary efficacy immunotherapy drugs for tumours. Methods analysis phase II, open-label, non-randomised, multiarm, single-centre trial patients advanced who failed...
Objective The aim of the present study was to examine value high-density lipoprotein (HDL) subfractions for predicting cardiovascular events (CVEs) in untreated type 2 diabetes mellitus (T2DM) patients with stable coronary artery disease (SCAD) using an age- and gender-matched case-control study. Methods In total, 185 SCAD T2DM were enrolled subjected a clinical follow-up CVEs. HDL analyzed Quantimetrix Lipoprint System. relationship between CVEs evaluated by Kaplan–Meier analysis Cox...
To report a case of Hutchinson-Gilford progeria syndrome (HGPS). Peripheral blood samples were collected from 5-year-old boy with HGPS and his parents. DNA was extracted these samples, PCR performed to amplify exon 11 the LMNA gene its flanking sequences followed by sequencing. The patient presented scleroderma-like skin changes all over body, growth retardation, distinctive facial features hypotrichosis. His hip knee joints could not be straightened completely, giving horse-riding stance. A...
Shade has a direct impact on photosynthesis and production of plants. Exposure to shade significantly reduces crops yields. Identifying shade-tolerant genomic loci soybean varieties is crucial for improving In this study, we applied treatment (30% light reduction) natural population consisting 264 accessions, measured several traits, including the first pod height, plant number per plant, grain weight branch number, main stem node number. Additionally, performed GWAS these six traits with...
Metastatic spread of lung adenocarcinoma to the stomach is rare and most gastric metastases are discovered at advanced stage due certain symptoms. The present study reported two cases asymptomatic from presenting as diminutive nodules or erosion endoscopically. manifestations were also visualized under magnifying endoscopy with blue laser imaging (BLI-ME), share common characteristics BLI-ME, such an obviously widened intervening part extended subepithelial capillary network, which indicated...