A5068511941- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune cells in cancer
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Neurofibromatosis and Schwannoma Cases
- Flavonoids in Medical Research
Xiangya Hospital Central South University
2019-2025
Central South University
2019-2025
Jilin Province Tumor Hospital
2017
Soochow University
2008-2017
Second Military Medical University
1995-2016
The First People's Hospital of Changzhou
2013
Soochow University
2012
Eastern Hepatobiliary Surgery Hospital
1995
Abstract Purpose: Radiofrequency ablation (RFA) has been shown to elicit tumor-specific T-cell immune responses, but is not sufficient prevent cancer progression. Here, we investigated immune-suppressive mechanisms limiting the efficacy of RFA. Experimental Design: We performed a retrospective case-controlled study on patients with synchronous colorectal liver metastases who had received primary tumor resection or without preoperative RFA for metastases. Tumor-infiltrating T cells and...
Abstract Radiofrequency ablation (RFA) promotes tumor antigen-specific T cell responses and enhances the effect of immunotherapy in preclinical settings. Here we report that existence remnant masses due to incomplete RFA (iRFA) is associated with earlier new metastases poor survival patients colorectal cancer liver (CRCLM). Using mouse models, demonstrate iRFA progression hinders efficacy anti-PD-1 therapy. Immune analysis reveals induces sustained local inflammation predominant myeloid...
Abstract RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating splicing, translation, transport, and stability. Notably, studies have illuminated the substantial impact of methylation on tumor immunity. The primary types encompass N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), 3-methylcytidine...
To determine the long-term efficacy of adjuvant immunotherapy with autologous cytokine-induced killer (CIK) cells for locally advanced gastric cancer patients.One hundred and fifty-one patients stage III/IV who had undergone gastrectomy were enrolled, assigned to two groups (immunotherapy group versus no group/or control group), followed.The 5-year overall survival (OS) disease-free (DFS) rates 32.4 23.4 % (P = 0.071) 28.3 10.4 0.044), respectively. For intestinal-type tumors, OS DFS...
It remains controversial whether tumour mutational burden (TMB) or neoantigens are prognostic markers in hepatocellular carcinoma (HCC). This study aimed to define the function of TMB antitumour immunotherapy.Neoantigens patients (n=56) were analysed by pVAC tools with major histocompatibility complex-1 (MHC-I) algorithms based on whole exome sequencing and mutant type IC50 <50 nM defined as high-affinity (HANs). Patients segregated into HAN-high/low groups median HAN value, overall survival...
Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric tissues, over-expression was significantly associated with progression and patients' postoperative prognoses. However, as now, how regulates the biological function cells still remains elusive.We constructed stable knockdown expression cell lines by using RNAi method, further investigated changes functions including viability, migration, invasion, cycle, apoptosis,...
The detailed understanding of the immunobiology tumor microenvironment has recently translated into new therapeutic approach against human cancers. Besides role immune cells mediating adaptive responses, infiltrating components innate system including, neutrophils, mast cells, NK and macrophages, also importantly in anti-tumor immunity. In our present study, we retrospectively analyzed prognostic value densities macrophages esophageal cancer tissues derived from stage II+III patients. Our...
Abstract The FOXO signaling pathway has been reported to have an important role in human cancer. Expression of miR-629 was markedly upregulated pancreatic cancer and negatively correlated with FOXO3. Therefore, exploring the regulatory mechanism FOXO3 may provide valuable clinical targets for therapy. In current study, we found that overexpressing inhibiting miR-629, respectively, enhanced reduced cell proliferation metastasis cells vitro vivo compared parental or transfected a control...
Liver cancer, specifically hepatocellular carcinoma (HCC), stands out as one of the most formidable solid tumors, characterized by a dauntingly low survival rate. At forefront tumor microenvironment (TME) orchestrating initiation and advancement HCC are cancer-associated fibroblasts (CAFs). TGF-β, widely recognized potent activator CAFs, not only regulates their activity but also assumes pivotal role in metastatic journey tumor. In our recent study, drawing from GEO database, we identified...
Purpose Early prediction of the prognosis viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim this study to explore a comprehensive prognostic assessment model evaluating survival outcomes post-TIPS.
Radiofrequency ablation (RFA) causes coagulative necrosis of tumor tissue and the production local protein debris. These fragments debris contain a large number various antigens, which can stimulate specific cellular immune response. In present study, dendritic cells (DCs) were loaded with lysate antigens that produced in situ by RFA, used to treat murine colon carcinoma combination cytokine‑induced killer (CIK) cells. Subsequent treatment supernatant lysis was collected DCs antigen generate...
Background/Aims: T-bet, a member of the T-box family transcription factors, is key marker type I immune response within tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients potential biomarker immunotherapy. In present study, we aimed assess clinical significance value T-bet+ tumor-infiltrating lymphocytes in epithelial ovarian cancer. Methods: The immunohistochemistry was used analyze infiltration...
Purpose: This phase II/III, non-randomized clinical trial aimed to determine the efficacy and safety of combination radiofrequency ablation (RFA) cytokine-induced killer (CIK) cells transfusion for patients with colorectal liver metastases (CRLMs). Experimental Design: A total 60 eligible CRLMs were enrolled divided into Group (RFA alone, n = 30) B plus CIK, 30), following enzyme-linked immunosorbent spot assay was performed in 8 CEA > 50 ng/mL pre-RFA 7 days post-RFA CIK treatment,...
Radiation encephalopathy (RE) is an important potential complication in patients with nasopharyngeal carcinoma (NPC) who undergo radiotherapy (RT) that can affect the quality of life. However, a functional imaging biomarker pre-symptomatic RE has not yet been established. This study aimed to assess radiation-induced gray matter alterations and explore fractional amplitude low-frequency fluctuation (fALFF) as for predicting or diagnosing NPC. A total 60 NPC were examined, 21 pre-RT cohort 39...
Deguelin is a naturally occurring rotenoid with marked chemopreventive and antitumor activity. Cisplatin, characterized by damaging DNA, widely used in the chemotherapy of malignancies, including gastric cancer. The present study investigated whether synergistic effects exist between combination deguelin cisplatin, possible mechanism vitro. interactive various concentrations cisplatin were evaluated human cancer MGC‑803 cell line. inhibition proliferation was determined...
In recent years, the number of patients exhibiting multiple primary malignant neoplasms has been increasing. The current study reports rare case a 61-year-old Chinese female with eight histopathologically confirmed neoplasms; to best our knowledge, such high in one patient not previously described English literature. tumors originated from colon (five separate over 32 years), endometrium, breast and small intestine. It is important diagnose as generally exhibit more favorable prognosis...
The co-stimulatory ligands of B7-family have been confirmed to play an important role in negatively regulating the T-cell mediated anti-tumor immunity. In addition, these inhibitory molecules are also aberrantly expressed on various human cancers tissues, and significantly associated with cancer progression patients' poor prognoses. We previously reported that B7-H3 B7-H4 highly esophageal tissues. Herein, we tried further analyze value their combined expression prognostic prediction for...
Abstract Background Locoregional recurrence is the typical pattern of in gastric cancer, and cannot be removed by surgery most patients. We aimed to evaluate feasibility efficacy computed tomography (CT)-guided brachytherapy for patients with locoregional recurrent cancer. Materials methods reviewed case histories 28 cancer that were selected CT- guided a multidisciplinary team. The clinical data including patient characteristics, treatment parameters, short-term effects, survival collected...
The treatment of gastric cancer has been unsatisfactory thus far; therefore, novel targets and strategies are urgently required. Lemur tyrosine kinase (LMTK)3 is an estrogen receptor-α (ERα) modulator with a central role in endocrine resistance breast cancer. Moreover, the expression polymorphisms LMTK3 correlated prognosis patients. Since receptor (ER) also expressed plays cancer, we herein investigated protein 83 patients by tissue microarray analyzed correlation between Our results...
To evaluate the efficacy of hepatic artery infusion (HAI) floxuridine (FUDR) in combination with systemic chemotherapy patients pancreatic cancer liver metastases (PCLM).We retrospectively collected clinical data 347 PCLM who underwent first-line at two Chinese centers between 2012 and 2019. Propensity score matching without HAI was performed to compensate for differences baseline characteristics. Objective response rate (ORR) overall survival (OS) groups were compared. pump functionality...