A5108046712- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Aquaculture Nutrition and Growth
- Single-cell and spatial transcriptomics
- Reproductive biology and impacts on aquatic species
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- Pneumonia and Respiratory Infections
- Medicinal Plant Pharmacodynamics Research
- Hepatocellular Carcinoma Treatment and Prognosis
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Intensive Care Unit Cognitive Disorders
- Cell Adhesion Molecules Research
- Influenza Virus Research Studies
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 and healthcare impacts
Fujian Medical University
2012-2025
Xiamen University
2018-2025
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Huzhou Central Hospital
2024
Second Military Medical University
2017-2023
Hangzhou Medical College
2023
Affiliated Hospital of Hangzhou Normal University
2021-2023
The Fourth People's Hospital
2023
Shinshu University
2023
Abstract COVID-19, caused by SARS-CoV-2, has recently affected over 1,200,000 people and killed more than 60,000. The key immune cell subsets change their states during the course of COVID-19 remain unclear. We sought to comprehensively characterize transcriptional changes in peripheral blood mononuclear cells recovery stage single-cell RNA sequencing technique. It was found that T decreased remarkably, whereas monocytes increased patients early (ERS) COVID-19. There an ratio classical CD14...
Abstract Purpose: Radiofrequency ablation (RFA) has been shown to elicit tumor-specific T-cell immune responses, but is not sufficient prevent cancer progression. Here, we investigated immune-suppressive mechanisms limiting the efficacy of RFA. Experimental Design: We performed a retrospective case-controlled study on patients with synchronous colorectal liver metastases who had received primary tumor resection or without preoperative RFA for metastases. Tumor-infiltrating T cells and...
Abstract Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the that human circulating undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry scATAC-seq compare cell types peripheral blood collected from young old subjects patients COVID-19. We found landscape was reprogrammed characterized by T polarization naive memory effector, cytotoxic, exhausted regulatory cells, along late...
Abstract Background COVID‐19 is currently a global pandemic, but the response of human immune system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection remains unclear. Noncoding RNAs serve as regulators and thus may play critical role in disease progression. Methods We performed multi‐transcriptome sequencing both noncoding mRNAs isolated from red blood cell depleted whole moderate patients. The functions were validated by analyses expression downstream mRNAs. further...
The substantial heterogeneity and hierarchical organization in liver cancer support the theory of stem cells (LCSCs). However, relationship between chronic hepatic inflammation LCSC generation remains obscure. Here, we observed a close correlation aggravated progenitor cell (LPC) propagation cirrhotic rats exposed to diethylnitrosamine. LPCs isolated from rat initiated subcutaneous cancers nonobese diabetic/severe combined immunodeficient mice, suggesting malignant transformation toward...
<h2>Summary</h2><h3>Background</h3> Ocular changes are traditionally associated with only a few hepatobiliary diseases. These non-specific and have low detection rate, limiting their potential use as clinically independent diagnostic features. Therefore, we aimed to engineer deep learning models establish associations between ocular features major diseases advance automated screening identification of from images. <h3>Methods</h3> We did multicentre, prospective study develop using slit-lamp...
Abstract Background Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by . Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. Case presentation This report included five cases of pneumonia. Symptoms signs common all 5 fever, coughing, generalized muscle ache, most notably, inflammatory infiltration the lungs upon chest CT X-ray. Metagenomic next-generation sequencing (mNGS) revealed presence in...
Feeding trials were conducted to determine the dietary level of yeast extract (YE) for replacing fish meal evaluating whether was superior intact as an alternative protein source shrimp Litopenaeus vannamei. The basal diet (control, D0, containing 25% meal), compared with five isonitrogenous and isoenergetic experimental diets [replacing 15% (D15), 30% (D30), 45% (D45), 60% (D60) or 100% (D100) in IYE]. digestibility, growth muscle composition measured. results showed that all replacement...
Abstract Introduction To clarify the expression of caveolin‐1 in human peritoneal vascular endothelial cells (HUM‐CELL‐0116) and investigate whether dialysis fluid (PDF) can promote permeability through caveolae/caveolin‐1‐mediated endocytosis. Methods HUM‐CELL‐0116 were passaged divided into following groups: control group, PDF Filipin DMSO antibody group. The cultured for 0, 4, 12, 24, 48 h. Then, we detected monolayer caveolin‐1. Results (1) Expression caveolin‐1: In decreases after...
Purpose The aim of this study was to investigate the prognostic value abnormal expression anaplastic lymphoma kinase (ALK) protein in patients with small cell lung cancer (SCLC) based on 9-year data from our center. Methods A retrospective cohort conducted assess clinical outcomes ALK-positive SCLC diagnosed hospital over past 9 years. We used public databases analyze ALK pan-cancer and its analyzed correlation between prognosis-related genes. Results total 685 underwent testing, 59 were...
Abstract Coronavirus disease 2019 (COVID-19), driven by SARS-CoV-2, is a severe infectious that has become global health threat. Vaccines are among the most effective public tools for combating COVID-19. Immune status critical evaluating safety and response to vaccine, however, evolution of immune during immunization remains poorly understood. Single-cell RNA sequencing (scRNA-seq) represents powerful tool dissecting multicellular behavior discovering therapeutic antibodies. Herein,...
Patients with rheumatoid arthritis are prone to atherosclerosis. We explored the role of elevated level monocyte chemotactic protein-1 (MCP-1)-induced protein (MCPIP) in endothelial dysfunction associated arthritis.The MCP-1 was sera from mice collagen-induced (CIA) and negatively correlated endothelium-dependent vessel dilation. Aortas CIA showed increased expression MCPIP but decreased bioavailability NO synthase-derived NO. Administering neutralizing antibody aortas alleviated...
Chronic obstructive pulmonary disease (COPD) is a major global epidemic with increasing incidence worldwide. The pathogenesis of COPD involved mitochondrial autophagy. Recently, it has been reported that FUN14 domain containing 1 (FUNDC1) mediator Therefore, we hypothesized FUNDC1 was in cigarette smoke (CS)-induced progression by regulating In vitro extract (CSE)-treated human bronchial epithelial cell (hBEC) Beas-2B line and vivo CS-induced mouse models were developed, which expression...
Yilun Wei, Jinhe Xu, Xiulian Huang, Siting Xie, Ping Lin, Chenxi Wang, Yuxin Guo, Shumei Zou, Zhongquan Zhao, Wen Wen, Yingfang Song, Zhenming Bao, Lei Zhang, Wei Liu, Wencui Kong, Wenwu Baochang He, Shenghang Chengzhi Zhou, Ying Chen, Zongyang Yu
Background Health-related quality of life (HRQOL) has become commonly used both as a concept and field research. However, little is known about the HRQOL men who have sex with women (MSMW). The aim this study was to examine HIV-related behaviors, social support, status explore its predictors among MSMW. Methods An anonymous cross-sectional conducted by snowball sampling method in 2013. A total 563 Chinese MSM completed structured questionnaire. support were measured version World Health...
To the Editor: Primary pulmonary enteric adenocarcinoma (P-PEAC), classified as a variant of lung with invasive mucinous adenocarcinoma, colloid and fetal by International Association for Study Lung Cancer, American Thoracic Society, European Respiratory was rare type adenocarcinoma.[1] In clinical practices, P-PEAC is easily confused secondary (S-PEAC) that manifested infiltration onset. Therefore, retrospective study carried out to investigate difference manifestation, imaging...