A5088558686- CRISPR and Genetic Engineering
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Antimicrobial agents and applications
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Structural Health Monitoring Techniques
- MicroRNA in disease regulation
- MXene and MAX Phase Materials
- Monoclonal and Polyclonal Antibodies Research
- Nanowire Synthesis and Applications
- Genetic Associations and Epidemiology
- Complement system in diseases
- Vibrio bacteria research studies
- Surgical Sutures and Adhesives
- Trace Elements in Health
- Extracellular vesicles in disease
- SARS-CoV-2 detection and testing
- Nephrotoxicity and Medicinal Plants
- Salmonella and Campylobacter epidemiology
- Liver Disease Diagnosis and Treatment
- Dam Engineering and Safety
- Aquaculture disease management and microbiota
- Cancer Diagnosis and Treatment
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2024-2025
Nanjing Hydraulic Research Institute
2024-2025
Xiamen University
2022-2024
Fujian Medical University
2022-2024
Xiamen University of Technology
2024
Fujian University of Traditional Chinese Medicine
2024
117th Hospital of People's Liberation Army
2021
Respiratory tract infections (RTIs) pose a grave threat to human health, with bacterial pathogens being the primary culprits behind severe illness and mortality. In response pressing issue, we developed centrifugal microfluidic chip integrated recombinase-aided amplification (RAA)-clustered regularly interspaced short palindromic repeats (CRISPR) system achieve rapid detection of respiratory pathogens. The limitations conventional two-step CRISPR-mediated systems were effectively addressed...
Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability...
Leakage is the most common issue encountered in earth–rock dam projects, with characteristics of strong concealment initial stage and rapid development significant threat later stage. For a accurate detection leakage dams, this paper introduces an infrared thermal imaging technology by fully considering correlation between temperature. The principle behind application for noncontact water dams was expounded. Based on theory flow–heat coupling combined numerical simulation test under effects...
Multidrug-resistant bacteria infections frequently occur in wound care due to the excessive use of antibiotics. It can cause scar formation, closure delay, multiple organ failure, and high mortality. Here, a double network hydrogel with injectability, hemostasis, antibacterial activity was developed prompt multidrug-resistant infected healing. The is composed gelatin methacryloyl (GelMA), oxidized dextran (ODex), ε-polylysine (EPL), bacitracin, formed through Schiff-base UV-initiated...
Yilun Wei, Jinhe Xu, Xiulian Huang, Siting Xie, Ping Lin, Chenxi Wang, Yuxin Guo, Shumei Zou, Zhongquan Zhao, Wen Wen, Yingfang Song, Zhenming Bao, Lei Zhang, Wei Liu, Wencui Kong, Wenwu Baochang He, Shenghang Chengzhi Zhou, Ying Chen, Zongyang Yu
Listeria monocytogenes (LM) is one of the most common food-borne pathogens and can induce a series diseases with high mortality rate to humans; hence, it very necessary develop highly sensitive method for LM detection. Based on this need, new sandwich-like electrochemical immunosensing platform was developed herein by preparing carboxyl Ti3C2Tx MXene (C-Ti3C2Tx MXene) as sensing rhodamine b/gold/reduced graphene oxide (RhB/Au/RGO) signal amplifier. The conductivity large surface area...
Low serum amylase activity and copy number (CN) variation (CNV) of the salivary gene (AMY1) are reportedly associated with obesity abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify relationship between CNV AMY1/2A/2B occurrence metabolic syndrome (MetS) in Chinese adults.Anthropometry, risk factors, were assessed 560 subjects (260 MetS patients; 300 healthy controls). CNs evaluated using highly sensitive droplet digital PCR.The total,...
Timely and accurate identification of leakage is vital for ensuring the safe operation embankment projects. However, few studies have considered utilizing information related to temperature-field anomalies on dam surfaces obtained through infrared thermal imaging in detection process. In this context, explore feasibility characteristics detecting dams under natural environmental conditions, study fully correlation between temperature, on-site inspection tests were conducted based imaging. By...
Background: Vibrio vulnificus can cause serious infections in human beings associated with the consumption of raw oysters or cuts exposed to seawater. The traditional method for culturing V. is time-consuming and has a high failure rate. Objectives: This study aims detect using an AMCA-modified specific DNA aptamer. Methods: Common pathogenic microorganisms present seawater Fujian Sea area were collected, cultured, identified. samples found contain mainly vulnificus, Staphylococcus aureus,...
Abstract Elevated expression of ERBB3 receptor correlates with increased distant metastasis breast cancers amplification and/or overexpression ERBB2 (HER2/neu), which the underlying molecular mechanism remains unclear. In recent years, cumulative studies have demonstrated that mesenchymal stem cells (MSCs), one important cellular components in tumor microenvironment, play roles multiple hallmarks cancer including invasion and metastasis. However, its role ERBB2-positive as well precise...
Rapid detection of heparin-binding protein (HBP) is essential for timely intervention in sepsis cases. Current techniques are usually antibody-based immunological methods, which have certain problems, such as complexity and slow detection, fall short meeting the urgency clinical needs. The application an aptamer can address these concerns well. In this study, HBP-specific DNA aptamers were screened first. Among which, Apt-01, Apt−02, Apt−13 had a high affinity HBP, exhibiting impressive KD...
Multidrug−resistant bacteria infections frequently occur in wound care due to the excessive use of antibiotics. It can cause scars formation, closure delaying, multiple organ failure, and high mortality. Here, a double network hydrogel with injectability, hemostasis, antibacterial activity was developed prompt multidrug−resistant infected healing. The composed gelatin methacryloyl (GelMA), oxidized dextran (ODex), ε-polylysine (EPL), bacitracin, formed through Schiff−base UV-initiated...