A5082642554- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
Peking University
2019-2024
Center for Life Sciences
2019-2024
The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME. Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal disentangle factors shaping By aligning CD45+ across different tissues, classified exhausted CD8+ T (Texs) activated regulatory as M-type, whose phenotypes were associated with malignancy, while natural...
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression. To depict their phenotypic and functional diversities the microenvironment, we perform integrative single-cell RNA sequencing analyses on NK from 716 patients with cancer, covering 24 cancer types. We observed heterogeneity cell composition a tumor-type-specific manner. Notably, have identified group of tumor-associated that are enriched tumors, show impaired anti-tumor functions,...
Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism tumor-reactive has important therapeutic implications. Yet DNA methylation status this cell not been elucidated.In study, we segregate bystander TILs, as well naïve effector memory subtypes controls from colorectal cancer patients, to compare their transcriptome methylome characteristics. Transcriptome profiling...
Summary Despite sustained clinical responses to immune-checkpoint blockade (ICB) therapies in non-small-cell lung cancer (NSCLC), the majority of patients derive no benefits, and cellular molecular underpinnings such resistance remain incompletely understood. To identify cell types that may influence immunotherapy responses, we first integrated newly generated previously published single-cell RNA sequencing data from 110 treatment-naïve with NSCLC. Among tumor-resident types, identified MMP1...
SUMMARY Dysfunctional immune response in the COVID-19 patients is a recurrent theme impacting symptoms and mortality, yet detailed understanding of pertinent cells not complete. We applied single-cell RNA sequencing to 284 samples from 205 controls create comprehensive landscape. Lymphopenia active T B cell responses were found coexist associated with age, sex their interactions COVID-19. Diverse epithelial types observed be virus-positive showed dramatic transcriptomic changes. Elevation...