A5050473535- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Mechanisms of cancer metastasis
- Patient-Provider Communication in Healthcare
- Health Literacy and Information Accessibility
- Gastric Cancer Management and Outcomes
- Healthcare Systems and Reforms
- Colorectal and Anal Carcinomas
- Global Maternal and Child Health
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- AI in cancer detection
- Clinical Nutrition and Gastroenterology
- RNA Interference and Gene Delivery
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Empathy and Medical Education
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Healthcare Policy and Management
- Communication in Education and Healthcare
- Galectins and Cancer Biology
Huazhong University of Science and Technology
2013-2019
Soochow University
2016-2017
Jilin Province Tumor Hospital
2017
Background/Aims: PD-L1 (Programmed cell death 1 ligand 1, PD-L1), an essential immune checkpoint molecule in the tumor microenvironment, is important target for cancer immunotherapy. We have previously reported that its expression human gastric and esophageal tissues significantly associated with progression patients’ postoperative prognoses. Its cells well known to inhibit T cell-mediated anti-tumor response, this mechanism of action has been targeted As now, autonomous effect on not...
Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric tissues, over-expression was significantly associated with progression and patients' postoperative prognoses. However, as now, how regulates the biological function cells still remains elusive.We constructed stable knockdown expression cell lines by using RNAi method, further investigated changes functions including viability, migration, invasion, cycle, apoptosis,...
The World Health Report 2000 stated that increased public financing for healthcare was an integral part of the efforts to achieve equity access. In 2009, Chinese government launched a three-year health reform program Through this program, intended increase its investment in primary institutions (PHIs). However, reports about outcome and improvement access have yet be presented. Stratified sampling employed research. samples used study comprised 34 community service centers (CHSCs) 92...
Background/Aims: T-bet, a member of the T-box family transcription factors, is key marker type I immune response within tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients potential biomarker immunotherapy. In present study, we aimed assess clinical significance value T-bet+ tumor-infiltrating lymphocytes in epithelial ovarian cancer. Methods: The immunohistochemistry was used analyze infiltration...
The aim of this study was to evaluate the correlations between p53, COX2, EGFR, nm23 expression and progression free survival (PFS) post-operative patients with colorectal carcinoma. Immunohistochemistry used detect EGFR in 459 specimens from carcinoma patients. Kaplan-Meier estimates, Cox proportional hazard regression analyses hierarchical were performed on collected data. estimates analysis suggested that as a negative predictor, median PFS high 21.73 months, low 57.83 months (χ2=20.880,...
Nutritional support for patients in the intensive-care unit (ICU) is a part of standard care which promotes medical quality and decreases nosocomial infection. Supplemental parenteral nutrition (SPN) approach (enteral (EN) combined with (PN) when EN alone insufficient) has become one major concern research field. This aims to explore following relationships: (i) relationship between SPN infection, (ii) early late initiation development
Background: Previous studies have ignored the bidirectional causality and heterogeneity of health level. This study explored between pharmaceutical expenditure (PE) total health-care (Total HCE) considering level for effective investment national improvement.Methods: Based on panel data PE Total HCE in 32 OECD countries China, Granger test was applied. Countries were divided into low- high-health-level (LH HH) groups according to their life expectancies.Results: A 1% increase growth rate per...
The prevalence and feature of online textual pediatrician-parent communication (OPPC) have been recognized, but evidence on OPPC assessment remains insufficient. This study aimed to develop validate an instrument provide measurement quality characteristics for management. 490 exchanges 61 tertiary hospitals from 9 Chinese provinces were obtained the Spring Rain Doctor website. SEGUE framework, feature, a pilot considered establish instrument. An empirical was conducted it incidence items...
According to the relevant reports, TIMP-2 polymorphism might be associated with susceptibility gastric cancer. Owing inconclusive results from published studies based on association between single nucleotide polymorphisms (SNPs) and cancer susceptibility, a meta-analysis was conducted investigate correlation SNPs risk of cancer.PubMed, Embase, CNKI Wanfang databases were systematically searched cover all two before April 2016. Pooled odds ratios (ORs) 95% confidence intervals calculated for...
Objective To study the impact of downregulating negative costimulation molecule B7-H1 on biological behaviors in esophageal cancer cell line Eca-109. Methods Down-regulation was performed by using RNAi method human Eca-109. The expression level confirmed flow cytometry and Western blotting. counting kit-8 (CCK-8) assay, scratch assay Transwell were used to investigate contribution cells. Results We successfully constructed stably reduced named Eca109-B7-H1-small interfering RNA...
Objective To evaluate the predictive value of epidermal growth factor receptor (EGFR) and nm23 expression its guiding role choosing chemotherapy regimen in post-operation patients with rectal carcinoma. Methods The EGFR 243 specimens carcinoma tissues was examined by immunohistochemistry. The clinical pathological data were recorded, followed up for more than five years. Kaplan-Meier estimates, Cox proportional hazard regression hierarchical analyses employed to assess correlation...
Objective To discuss the expression of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) in gastric cancer tissue, and to analyze correlation level IFIT2 clinical features prognosis patients. Methods Immunohistochemical staining method was used detect 90 cases tissue corresponding normal adjacent tissues chip. The rank sum test compare difference chi-square features. Kaplan-Meier overall survival, Cox model fitted estimate different indexes...