A5039545143- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer Risks and Factors
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Galectins and Cancer Biology
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Surgical Treatments
- Systemic Lupus Erythematosus Research
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Mechanisms of cancer metastasis
- Extracellular vesicles in disease
- Abdominal Trauma and Injuries
- Genetic factors in colorectal cancer
- Rheumatoid Arthritis Research and Therapies
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- Cytokine Signaling Pathways and Interactions
- Medical Imaging and Analysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ultrasound and Hyperthermia Applications
Beijing Chao-Yang Hospital
2013-2025
Capital Medical University
2013-2025
Lanzhou University
2019-2024
Lanzhou University Second Hospital
2019-2024
Peking University Cancer Hospital
2015-2024
South Australian Health and Medical Research Institute
2024
Peking University
2015-2024
Shanghai University of Medicine and Health Sciences
2021-2024
First Affiliated Hospital of Soochow University
2014-2022
Guangzhou Medical University
2022
Abstract Purpose: Tumor genomic features have been of particular interest because their potential impact on the tumor immune microenvironment and response to immunotherapy. Due substantial heterogeneity, an integrative approach incorporating diverse molecular is needed characterize immunologic underlying primary resistance immunotherapy for establishment novel predictive biomarkers. Experimental Design: We developed a pan-cancer deep machine learning model integrating mutation burden,...
As a selective estrogen receptor β agonist, the natural flavonoid liquiritigenin reportedly inhibits invasiveness of breast cancer cells, but its specific role and mechanism remain largely unclear. In this study, cells from triple negative lines MDA-MB-231 BT549 were incubated with different concentrations liquiritigenin. The results indicated that low had no significant cytotoxic effect, whereas high decreased viability both cells. Liquiritigenin treatment also resulted in increased...
The spinal endoscopic technique has been extensively documented in decompression procedures for treating lumbar degenerative diseases. However, there is limited literature on the fusion techniques. This study evaluates outcomes and safety of full-endoscopic posterior interbody (Endo-PLIF) treatment A retrospective case series was conducted at Beijing Chaoyang Hospital, Capital Medical University, involving 43 patients who underwent Endo-PLIF between February 2020 March 2021, with a minimum...
CD47/SIRPα interaction serves as an immune checkpoint for macrophage-mediated phagocytosis. Mouse anti-CD47 blocking antibodies had demonstrated potent efficacy in the treatment of both leukemic and solid tumors preclinical experimentations, therefore moved forward rapidly into clinical trials. However, a fully human antibody, which meets purpose better, has not been reported CD47 up to date. In this study, we isolation ZF1, from phage display library. ZF1 displayed high specificity affinity...
The drug resistance and the immune suppression in tumor microenvironment are important factors affecting progression. Reversing changing ideal ways to inhibit aim of study is verify antitumor response probiotics patients with colorectal carcinoma explore its mechanism. To detect samples 122 after surgery, analyze effect on enhancing tumor-infiltrating CD8+T cells carcinoma, further mechanism through animal experiments. results immunohistochemistry showed that proportion treated before...
The expression of homeobox A10 (HOXA10) in endometrial stromal cells is regulated by steroid hormones, especially estrogen. As a precursor molecule estrogen, abnormal cholesterol metabolism significantly positively correlated with endometriosis. purpose this study was to explore the regulation HOXA10 on synthesis cells.mRNA data eutopic cell (ESC) and ovarian endometriotic cysts (OESC) were download from Gene Expression Omnibus (GEO) databases. Overexpression silence conducted cultured ESC...
Autoimmune thyroid disease (AITD), the most common autoimmune disease, includes Graves’ (GD) and Hashimoto’s thyroiditis (HT). Currently, pathogenesis of AITD is not fully understood. Our study aimed to examine presence macrophage polarization imbalance in patients, investigate whether high iodine can cause imbalance, role key genes metabolic reprogramming caused by iodine. We synergistically used various research strategies such as systems biology, clinical studies, cell culture mouse...
Introduction Autoimmune thyroid diseases (AITDs) are prevalent disorders, primarily encompassing Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Despite their common occurrence, the etiology of AITDs remains elusive. Th9 cells, a new subset CD4+T cells with immunomodulatory properties, have been linked to development various autoimmune diseases. However, research on role in is limited. Methods We investigated expression cells,their functional cytokine IL-9, transcription factor IRF4...
Objective. Rheumatoid arthritis (RA) is a complex disease with unknown pathogenesis. In recent years, fewer have paid attention to the broad spectrum of systemic markers RA. The aim this study was identify exosomal candidate proteins in pathogenesis Methods. Totally, 12 specimens plasma from 6 RA patients and age- gender-matched controls Chinese population were obtained for nanoscale liquid chromatography coupled tandem mass spectrometry (nano-LC-MS/MS) analysis profiles. Results. A total...
Background Coflex, a type of interspinous process implant, can provide intervertebral dynamic stability for surgical segments and effectively relieve lumbocrural pain. However, few studies have described therapeutic strategies the avoidance Coflex implant complications. Methods complications in this study included intraoperative or postoperative spinous fracture, aggravated pain, dislodgment malposition. The were analyzed, applied according to specific complication. Visual Analogue Scale...
Human heat shock protein 60 (hHSP60) and apolipoprotein B-100 (ApoB-100) in oxidized low density lipoproteins are considered pro-atherosclerotic factors by inducing autoimmunity response, immunization with peptides from these two proteins can inhibit atherosclerosis animal models. In this study, we constructed chimeric containing ApoB-100 and/or hHSP60 human intestinal trefoil factor (ITF) as a scaffold then fused glutathionine-S transferase (GST) for expression Escherichia coli. These...
Background: ARASENS has demonstrated the efficacy and safety for darolutamide (DARO) with androgen deprivation therapy (ADT) plus docetaxel in metastasis hormone-sensitive prostate cancer (mHSPC). There is a lack of reports DARO ADT mHSPC though regimen used clinical from time to time. Moreover, recent studies have supported importance early rapid prostate-specific antigen (PSA) reduction, which correlates reduced disease progression improved survival patients mHSPC. This study aims evaluate...
Previous studies have shown that general and central obesity are each linked to adverse outcomes in gastrointestinal cancers. However, their combined effect on cancers surgery were less understood. This study aims integrate both examine the of gastric cancer different patterns. We retrospectively analyzed 248 patients who underwent between 2021 2023 a single institute. The Inbody720 body composition analyzer measured composition. evaluated relationship patterns - combining BMI with measures...
A retrospective case-control study.
The aim of this study was to evaluate the correlations between p53, COX2, EGFR, nm23 expression and progression free survival (PFS) post-operative patients with colorectal carcinoma. Immunohistochemistry used detect EGFR in 459 specimens from carcinoma patients. Kaplan-Meier estimates, Cox proportional hazard regression analyses hierarchical were performed on collected data. estimates analysis suggested that as a negative predictor, median PFS high 21.73 months, low 57.83 months (χ2=20.880,...