A5100331240- Pharmacological Effects of Natural Compounds
- Advanced Optical Network Technologies
- Plant-based Medicinal Research
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Bacterial Genetics and Biotechnology
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Alkaloids: synthesis and pharmacology
- Advanced Memory and Neural Computing
- Ocular Surface and Contact Lens
- Natural Compounds in Disease Treatment
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Chemical synthesis and alkaloids
- Liver Disease and Transplantation
- Berberine and alkaloids research
- Advanced Synthetic Organic Chemistry
- Microencapsulation and Drying Processes
- Ginger and Zingiberaceae research
- Neural Networks and Reservoir Computing
- Alcoholism and Thiamine Deficiency
- Chemical Reactions and Isotopes
- Psoriasis: Treatment and Pathogenesis
- Ginseng Biological Effects and Applications
Huazhong University of Science and Technology
2024
Tianjin University
2000-2024
Scripps Research Institute
2024
Wuhan University
2021-2022
Renmin Hospital of Wuhan University
2021-2022
Scripps (United States)
2020-2021
Scripps Institution of Oceanography
2020-2021
Freie Universität Berlin
2017-2021
Albert Einstein College of Medicine
2020
Paul Scherrer Institute
2020
The cerebellum plays a vital role in motor learning and control with supervised capability, while neuromorphic engineering devises diverse approaches to high-performance computation inspired by biological neural systems. This article presents large-scale cerebellar network model for learning, as well cerebellum-inspired architecture map the anatomical structure into model. Our multinucleus its underpinning contain approximately 3.5 million neurons, upscaling state-of-the-art designs over 34...
Novel nanogels that possess the capacity to change their physico-chemical properties in response external stimuli are promising drug-delivery candidates for treatment of severe skin diseases. As thermoresponsive (tNGs) capable enhancing penetration through biological barriers such as stratum corneum and taken up by keratinocytes human skin, potential adverse consequences exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) two polymers....
Abstract Objectives Aconitine, the natural product extracted from Aconitum species, is widely used for treatment of various diseases, including rheumatism, arthritis, bruises, fractures and pains. However, many studies have reported cardiotoxicity neurotoxicity caused by aconitine, but detailed mechanism underlying aconitine's effect on these processes remains unclear. Materials methods The effects aconitine inflammation, apoptosis viability H9c2 rat cardiomyocytes were evaluated flow...
Background: Liquiritin (LIQ) is a traditional Chinese medicine that has been reported to regulate inflammation, oxidative stress and cell apoptosis. However, the beneficial effects of LIQ in lipopolysaccharides (LPS)-induced septic cardiomyopathy (SCM) not reported. The primary goal this study was investigate LPS-induced SCM model. Methods: Mice were pre-treated with for 7 days before they injected LPS (10 mg/kg) inducing Echocardiographic analysis used evaluate cardiac function after 12 h...
As a selective estrogen receptor β agonist, the natural flavonoid liquiritigenin reportedly inhibits invasiveness of breast cancer cells, but its specific role and mechanism remain largely unclear. In this study, cells from triple negative lines MDA-MB-231 BT549 were incubated with different concentrations liquiritigenin. The results indicated that low had no significant cytotoxic effect, whereas high decreased viability both cells. Liquiritigenin treatment also resulted in increased...
Background: Liquiritin (LQ) is one of the main flavonoids extracted from roots Glycyrrhiza spp., which are widely used in traditional Chinese medicine. Studies both cellular and animal disease models have shown that LQ attenuates or prevents oxidative stress, inflammation, apoptosis. However, potential therapeutic effects on pressure overload-induced cardiac hypertrophy not been so far explored. Therefore, we investigated cardioprotective role its underlying mechanisms aortic banding...
Type 2 alveolar epithelial cells (AEC2s) are stem in the adult lung that contribute to lower airway repair. Agents promote selective expansion of these might stimulate regeneration compromised epithelium, an etiology-defining event several pulmonary diseases. From a high-content imaging screen drug repurposing library ReFRAME, we identified dipeptidyl peptidase 4 (DPP4) inhibitors, widely used type diabetes medications, selectively expand AEC2s and broadly efficacious mouse models damage....
The cell wall is an elaborate framework of peptidoglycan that serves to protect the bacterium against osmotic challenge. This exoskeleton composed repeating saccharides covalently cross-linked by peptide stems. general structure widely conserved across diverse Gram-negative bacteria. To begin explore biological consequence introducing non-canonical cross-links into Escherichia coli, we generated a where up 31% cell-wall are formed non-enzymatic reaction between sulfonyl fluoride and amino...
Noscapine is an antitussive and potential anticancer drug. Clinically significant interactions between warfarin noscapine have been previously reported. In this study, to provide a basis for dosage adjustment, the inhibition kinetics of against metabolism was characterized. Our enzyme data obtained from human liver microsomes recombinant CYP2C9 proteins indicate that competitive inhibitor (<i>S</i>)-warfarin 7-hydroxylation reaction by CYP2C9. Interestingly, also inhibited in NADPH-...
Kalimeris indica (L.) Sch. Bip. is a traditional Chinese medicine (TCM) and portion of food used for cooking in China. It has been demonstrated that an ethanol extract K. anti-inflammatory effect by inhibition nitric oxide (NO) production on murine macrophage RAW264.7 cells after lipopolysaccharide (LPS) induction. In this study, the hepatoprotective effects total phenolics (TPK), triterpenes (TTK), flavones (TFK) from extracts were evaluated Bacille Calmette-Guerin (BCG)/LPS-induced liver...
A plethora of micro- and nanoparticle types are currently investigated for advanced ocular treatment due to improved drug retention times, higher bioavailability better biocompatibility. Yet, comparative studies both physicochemical toxicological performance these novel delivery systems still rare. Herein, poly(L-lactic acid)- poly(ε-caprolactone)-based nanoparticles were loaded with prednisolone as a model drug. The properties the particles varied respect their hydrophilicity size well...
A novel copper(II) acetate mediated synthesis of 3-hydroxyphenanthridin-6(5<i>H</i>)-ones from <i>N</i>-(3-oxocyclohex-1-enyl)benzamides was developed. The process is postulated to involve an intramolecular oxidative C(sp<sup>2</sup>)–C(sp<sup>3</sup>) bond formation followed by dehydrogenative aromatization.
Significance The cell wall of bacteria is a biopolymer formed glycan chains cross-linked by interconnecting peptide stems. Elucidating the structure, biosynthesis, and recycling mechanisms important to understanding mechanism action β-lactam antibiotics development new antibiotics. Here we use synthetic biology approach probe structural biosynthetic constraints cell-wall architecture introducing noncanonical building blocks into walls living bacteria. We show that Gram-positive bacterium...
Waste-to-energy (WTE) plants are utilized for the production of heat and electricity from municipal solid waste (MSW) refused derived fuel (RDF). However, a desire to raise steam temperature in order improve electrical efficiency WTE has introduced potential high corrosion problems transfer surface, due chlorine content (0.5wt.%∼1.0wt.%) MSW. To study mechanism deposits chemistry, full scale investigations were therefore conducted plant Tianjin, China. Deposit probes inserted exposed flue...
The natural product (+)-discodermolide (DDM) is a microtubule stabilizing agent and potent inducer of senescence. We refined the structure DDM evaluated activity novel congeners in triple negative breast ovarian cancers, malignancies that typically succumb to taxane resistance. Previous structure-activity analyses identified lactone diene as moieties conferring anticancer activity, thus identifying priorities for structural refinement studies described herein. Congeners possessing monodiene...
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA characterized by immune cell infiltration abnormal proliferation synoviocytes in joints. Herein, we developed biomimetic formulation via co‐loading anti‐inflammatory agent Celastrol (Cel) along with stabilizer Vitamin K (VK) antirheumatic methotrexate (MTX)‐conjugated Pluronic F127 (F127) micelles. Micelles were then coated B derived membrane, yielding MTX...
This paper establishes leakage model base on water balance, night flow methodology and hydraulic model. Then apply the to real distribution system, result of which verifies that is practicable rational.
Objective: To invetigate the influencing factors and clinical significance of liver function damage (LFD) in patients diagnosed with Corona Virus Disease 2019 (COVID-19) Methods: The retrospective case-control study was conducted clinicopathological data 51 COVID-19 who were admitted to Sino-French New City Branch Tongji Hospital Affiliated Huazhong University Science Technology by 5th group assisting team from First Jilin February 9th 27th 2020 collected There 27 males 24 females, aged 36...
Abstract Optimized conditions using air as the terminal oxidant are elaborated to prepare biologically interesting phenanthridine derivatives.
Solid dispersions (SD) were prepared with naringenin and polyvinyl pyrrolidone k-30 (PVP k-30) by the solvent evaporation method three drying methods (microwave-vacuum drying, MVD; spray SPD; vacuum VD). The physical state was characterized DSC, PXRD, SEM, FT-IR. results showed that vitro dissolution rate extent of improved significantly SD as compared pure drug mixtures (PM). FT-IR is possibly interacted PVP via intermolecular hydrogen bond, DSC PXRD all completely amorphous. Compared other...