A5044237874- Metal Alloys Wear and Properties
- Microstructure and Mechanical Properties of Steels
- Metal and Thin Film Mechanics
- Advanced materials and composites
- Metallurgy and Material Forming
- Aluminum Alloys Composites Properties
- Advanced Glycation End Products research
- Advanced ceramic materials synthesis
- High-Temperature Coating Behaviors
- Cytokine Signaling Pathways and Interactions
- Metallic Glasses and Amorphous Alloys
- Complement system in diseases
- Diabetes and associated disorders
- Magnetic Properties of Alloys
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Atherosclerosis and Cardiovascular Diseases
- Thyroid Disorders and Treatments
- High Temperature Alloys and Creep
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Insect Utilization and Effects
Shanghai University of Traditional Chinese Medicine
2024-2025
Hebei University of Technology
2000-2024
Zhejiang University
2024
Zhejiang Taizhou Hospital
2024
Wenzhou Medical University
2024
Nanjing University of Science and Technology
2024
Shanghai University of Medicine and Health Sciences
2021-2023
Northwest Normal University
2023
Northwest A&F University
2021
Shanghai Xuhui Central Hospital
2020-2021
Abstract The advanced glycation end‐products (AGEs) are produced through non‐enzymatic between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body daily dietary intake also be generated internally via normal metabolism external stimuli. bind to cell surface receptors for AGEs, triggering oxidative stress inflammation responses that lead skin ageing various diseases. Evidence shows contribute dysfunction ageing. This review introduces...
Although ER stress in pancreas, liver, and adipose tissue was reported to be a novel event linked the pathogenesis of type 2 diabetes mellitus, there is much less information on this skeletal muscle. Some studies indicated that treatment with antioxidants had beneficial effects diabetes. This study focuses strong antioxidant, grape seed proanthocyanidin extracts ( GSPE ), muscle diabetic rats induced low dose streptozotocin‐ high‐carbohydrate/high‐fat diet. After 16 wk treatment, showed...
It is increasingly being realized that failure of pancreatic beta cells to secrete enough insulin adequately compensate for obesity and resistance the primary defects type 2 diabetes mellitus (T2DM). Pancreatic possess a highly developed active endoplasmic reticulum (ER), reflecting their role in folding, export processing newly synthesized insulin. ER stress-induced beta-cell novel event pathogenesis T2DM. Some studies with antioxidants indicated beneficial impact on stress. Our previous...
Podocytes are part of the glomerular filtration membrane in kidney and serve to prevent protein from blood. Several evidences suggest that mitochondrial dysfunction plays a critical role pathogenesis diabetic nephropathy it is an early event podocyte injury. Mitochondrial promotes oxidative stress can favor development Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) was considered be major regulator metabolic homeostasis function. Some studies indicated polyphenols may...
Grape seed proanthocyanidin extract (GSPE) is known to be an effective natural polyphenol capable of removing free radicals in vivo. It has been reported that GSPE biological functions including antioxidant, anti‑cancer, anti‑hyperglycemic, anti‑radiation, and prevention treatment cardiovascular diseases. This study aims investigate the effects on renal injury type 2 diabetic rats induced with low‑dose streptozotocin a high‑carbohydrate/high‑fat diet. Rats (n=12 per group) were administered...
Chlorogenic acid (CGA), a phenylpropanoid derived from Eucommia ulmoides Oliver, has been shown to exhibit potent cytotoxic and anti-proliferative activities against several human cancers. However, the effects of CGA on hepatocellular carcinoma (HCC) underlying mechanisms have not intensively studied. In this study, treatment viability hepatoma cells were investigated by MTT assay. Our data showed that could dose-dependently inhibit activity Hep-G2 Huh-7, but did affect growth normal...
This study aimed to explore the differential expression of co-stimulatory molecule CD226 in lymphocytes from patients with New-Onset Graves' Disease (NOGD) and its correlation clinical indicators. Sixty-eight participants were recruited for discovery experiment (NOGD: healthy control (HC) = 39:29). Peripheral Blood Mononuclear Cells (PBMCs) isolated. Flow cytometry was performed detect on multiple lymphocyte subtypes. mRNA PBMCs detected by qPCR. Fifty-eight validation HC=35:23). CD4+ T...
Grape seed proanthocyanidins (GSPs) possess a broad spectrum of pharmacological and therapeutic properties. The aim this study was to examine the effect GSPs on functional morphological abnormalities in peripheral nerves rats with type 2 diabetes mellitus. Diabetic were induced by two injections 25 mg streptozotocin/kg body weight 8 weeks high‐carbohydrate/high‐fat diet. then administrated for 16 weeks. Thermal mechanical sensitivity thresholds nerve conductive velocity measured evaluate...
Autoimmune thyroid disease (AITD) comprises Graves' (GD) and Hashimoto's thyroiditis (HT). IL37 has been recently proved to be a natural suppressor for innate immunity acquired immunity. Therefore, this study was conducted identify the association of genetic polymorphisms with AITD in Chinese Han population. Polymorphisms rs3811046/rs3811047/rs2723176/rs272186 gene were assessed case–control comprising 701 GD patients, 301 HT patients 939 controls. Genetic variants genotyped by multiplex...
Hashimoto's thyroiditis (HT) is one of the most common clinical autoimmune diseases. Recent studies have found that HT pathogenesis associated with macrophage polarization. Saikosaponin-d (SSd) an active component in Chinese medicine Bupleurum, which has anti-inflammatory and immunomodulatory effects. The purpose this study was to verify therapeutic effect SSd on investigate regulatory polarization HT. Network pharmacology analysis used predict relevant targets signaling pathways for...
The IKZF3 gene encodes a zinc-finger protein that plays an important role in the proliferation and differentiation of B lymphocytes. Autoimmune thyroid diseases (AITDs), mainly include Graves' disease (GD) Hashimoto's thyroiditis (HT), are probably caused by aberrant cells. objective this study was to explore association between polymorphisms AITDs.We examined 915 AITD patients (604 GD 311 HT) 814 healthy controls. variants (rs2941522, rs907091, rs1453559, rs12150079 rs2872507) were tested...
Autoimmune thyroid disease (AITD), the most common autoimmune disease, includes Graves’ (GD) and Hashimoto’s thyroiditis (HT). Currently, pathogenesis of AITD is not fully understood. Our study aimed to examine presence macrophage polarization imbalance in patients, investigate whether high iodine can cause imbalance, role key genes metabolic reprogramming caused by iodine. We synergistically used various research strategies such as systems biology, clinical studies, cell culture mouse...