A5087133100- Cytomegalovirus and herpesvirus research
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Air Quality and Health Impacts
- Antifungal resistance and susceptibility
- Neurosurgical Procedures and Complications
- Adenosine and Purinergic Signaling
- Image Processing Techniques and Applications
- Gut microbiota and health
- Anesthesia and Pain Management
- Salivary Gland Disorders and Functions
- Toxoplasma gondii Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Eicosanoids and Hypertension Pharmacology
- Liver Disease and Transplantation
Capital Medical University
2022-2025
Beijing Ditan Hospital
2025
The University of Queensland
2018-2024
Jiangnan University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Shanghai Tenth People's Hospital
2020-2022
Tongji University
2020-2022
Beijing Tian Tan Hospital
2021-2022
Lanzhou Army General Hospital
2011
Metabolic-associated fatty liver disease (MAFLD), which is previously known as non-alcoholic (NAFLD), represents a major health concern worldwide with limited therapy. Here, we provide evidence that ferroptosis, novel form of regulated cell death characterized by iron-driven lipid peroxidation, was comprehensively activated in tissues from MAFLD patients. The canonical-GPX4 (cGPX4), the most important negative controller downregulated at protein but not mRNA level. Interestingly,...
Rationale: Nicotinamide adenine dinucleotide+ (NAD+)-boosting therapy has emerged as a promising strategy to treat various health disorders, while the underlying molecular mechanisms are not fully understood. Here, we investigated involvement of fibronectin type III domain containing 5 (Fndc5) or irisin, which is novel exercise-linked hormone, in development and progression nonalcoholic fatty liver disease (NAFLD). Methods: NAD+-boosting was achieved by administrating nicotinamide riboside...
The sensitive and accurate diagnosis of nosocomial meningitis ventriculitis is still a critical problem. This study was designed to explore the diagnostic value cerebrospinal fluid heparin-binding protein (HBP) in comparison with procalcitonin lactate.In this observational study, 323 suspected patients were enrolled, which 42 participants excluded because they could not be accurately grouped, 131 subjects who eventually diagnosed or 150 whom infection ultimately ruled out included final...
Background: Given the high mortality associated with Cirrhotic Portal Hypertension (CPH) worldwide, this study investigates mechanism by which baicalin (BA), known for its beneficial effects on cirrhosis, alleviates CPH. Methods: The CPH model was established in Sprague-Dawley (SD) rats, followed 4-week oral administration of 30 and 60 mg/kg/day BA. SD rats were randomly assigned to four groups (n=6/group): Con, Model, BA-30, BA-60. vein smooth muscle cells (PVSMCs, extracted from n=6)...
Human cytomegalovirus (HCMV) colonizes blood-borne dendritic cells (DCs). They express US28, a viral G protein-coupled receptor (GPCR). In vitro functions have been described for but how it contributes to host colonization has unclear. The murine CMV (MCMV) M33 GPCR promotes DC recirculation. We show that US28 shares this function. Thus, recirculation is also available HCMV via and inhibiting protein-dependent signalling the potential reduce systemic infection. infection through infected...
Carbapenem-resistant Gram-negative bacteria (CRGNB)-related health care-associated ventriculitis and meningitis (HCAVM) is dangerous. We aimed to report the antimicrobial resistance of pathogens, treatment, outcome. All cases with CRGNB-related HCAVM in2012-2020 were recruited. Antimicrobial agents classified as active, untested, or inactive using susceptibility tests. The treatment stage was empirical targeted according pathogens. effect ineffective effective HCAVM-related parameters....
Cytomegaloviruses (CMVs) establish myeloid cell-associated viremias and persistent shedding from the salivary glands. In vitro studies with human CMV (HCMV) have implicated HCMV UL128 in epithelial tropism, but its role vivo is unknown. Here, we analyzed how a murine (MCMV) protein similar physical properties, designated MCK-2, contributes to host colonization.
Mercury (Hg), a ubiquitous heavy metal, could affect the neurodevelopment of children, however, these associations are still equivocal. Brain derived neurotrophic factor (BDNF) plays an essential role in central nervous system development children. This study aimed to investigate effects low-level mercury exposure on serum BDNF levels and influence sex dietary intake relationships In this cross-sectional study, total 541 pre-school children were recruited, blood concentrations measured. The...
G protein-coupled receptors (GPCRs) act as cell surface molecular “switches” that regulate the cellular response to environmental stimuli. All cytomegalovirus (CMV) genomes analyzed date possess GPCR homologs with phylogenetic evidence for independent gene capture events, signifying important in vivo roles.
Coagulase-negative staphylococci (CoNS) are the main pathogens in health care-associated ventriculitis and meningitis (HCAVM). This study aimed to assess antimicrobial susceptibility. Moreover, treatment clinical outcome were described. All neurosurgical adults admitted one of largest centers China with clinically significant CoNS isolated from cerebrospinal fluid cultures 2012 2020 recruited. One episode was defined as patient bacterial strain. Interpretive categories applied according...
According to clinical data, a significant percentage of patients experience pain after surgery, highlighting the importance alleviating postoperative pain. The current approach involves intravenous self-control analgesia, often utilizing opioid analgesics such as morphine, sufentanil, and fentanyl. Surgery for colorectal cancer typically general anesthesia. Therefore, optimizing anesthetic management analgesic programs can effectively reduce perioperative stress enhance recovery. study aims...
Cytomegaloviruses (CMVs) transmit via chronic shedding from the salivary glands. How this relates to broad cell tropism they exhibit in vitro is unclear. Human CMV (HCMV) infection presents only after gland established. Murine (MCMV) therefore useful analyse early events. It reaches glands infected myeloid cells. Three adjacent spliced genes designated as m131/129 (MCK-2), sgg1 and sgg1.1, positional homologues of HCMV UL128/130/131 determinants, are implicated. We show that a null mutant...
Abstract Background : Previous studies discuss the positive predictive value through whether bacteria are coagulase-negative staphylococci. The view may need to be updated. aim was evaluate of different species isolated from cerebrospinal fluid cultures and rationality staphylococci as a group. Methods This retrospective cohort study recruit all adults with sampled by lumbar puncture 2012-2020 in Department Neurosurgery. exposure species, outcome value. An episode defined patient one...