A5057851288- Robotic Mechanisms and Dynamics
- Lymphoma Diagnosis and Treatment
- Mechanical Engineering and Vibrations Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Dynamics and Control of Mechanical Systems
- CAR-T cell therapy research
- Skin and Cellular Biology Research
- Immunotherapy and Immune Responses
- Advanced Measurement and Metrology Techniques
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Natural Antidiabetic Agents Studies
- Glycosylation and Glycoproteins Research
- Mechanics and Biomechanics Studies
- Cellular Mechanics and Interactions
- Gestational Diabetes Research and Management
- Robot Manipulation and Learning
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Diet, Metabolism, and Disease
- Melanoma and MAPK Pathways
Suzhou Municipal Hospital
2013-2025
Nanjing Medical University
2013-2025
Cancer Genetics (United States)
2008-2024
Columbia University
2006-2024
Soochow University
2011-2024
Jilin Agricultural University
2019-2023
Shanxi Agricultural University
2018-2023
Anqing Normal University
2020
Wave Life Sciences (United States)
2020
Tongji Hospital
2017-2018
In response to T cell–dependent antigens, mature B cells are stimulated form germinal centers (GCs), the sites of cell affinity maturation and origin (COO) most lymphomas. To explore dynamics GC development beyond known dark zone light compartments, we performed single-cell (sc) transcriptomic analysis on human identified multiple functionally linked subpopulations, including distinct precursors memory plasma cells. The gene expression signatures associated with these subpopulations were...
The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose deregulation by genomic lesions implicated in the pathogenesis of GC-derived diffuse large B cell lymphoma (DLBCL) and, less frequently, follicular (FL). biological function only partially understood because no more than few genes have been functionally characterized as direct targets transrepression activity. Here we report anti-apoptotic BCL2 target GC cells. binds to...
The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose de-regulation involved in lymphomagenesis. Although substantial evidence indicates exerts its function by repressing the transcription of hundreds protein-coding genes, potential role regulating gene expression via microRNAs (miRNAs) not known. We have identified core 15 miRNAs show binding their genomic loci are down-regulated GC B cells. Among validated targets, miR-155...
Colorectal cancer is one of the major causes death from cancer. Metastasis leading cause treatment failure, in which stem cells and circulating tumor play crucial roles. Identifying involved metastatic biomarkers clarifying regulation mechanisms are great importance for targeting metastasis. In current research, we discovered that KIAA1199, a cell-migration inducing protein, showed higher expression CD44+ compared with paired primary tissues, was upregulated colorectal positively correlated...
Abstract Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT03950154) assessed efficacy and adverse events (AEs) of PD-1 blockade-activated DC-CIK (PD1-T) cells with XELOX bevacizumab as a first-line in patients mCRC. A total 202 participants were enrolled randomly assigned 1:1 ratio to receive either (the control...
Hypertrophic scarring (HSc) following burn injury is a common, disfiguring, and functionally limiting form of dermal fibrosis, compromising recovery. Previously, elevated levels transforming growth factor-beta1 (TGF-beta1), fibrogenic cytokine, were found in wounds serum severely injured patients, antagonized part by treatment with systemic interferon-alpha2b (IFN-alpha2b) both vitro vivo. It hypothesized that wound healing after injury, platelets are an initial source TGF-beta, but...
Although kidney injury caused by cisplatin has attracted much attention, cisplatin-induced cardiotoxicity is elusive. Our previous studies have confirmed that saponins (ginsenosides) from Panax quinquefolius can effectively reduce acute renal injuries. current study aimed to identify the potential effects of leaves P. (PQS) on cisplatin-evoked cardiotoxicity.Mice were intragastrically with PQS at doses 125 and 250 mg/kg daily for 15 days. The mice in group + groups received four times...
Although ginseng (Panax C.A. Meyer) has received extensive attention in the treatment and prevention of type 2 diabetes mellitus (T2DM) past few decades, there are studies on complications T2DM. At present, obesity-linked diabetic nephropathy (DN) become most prevailing element end-stage renal failure world. The aim this work is to evaluate ameliorative effects ginsenoside Rh1 (G-Rh1) DN induced by high fat diet plus streptozotocin (HFD/STZ) through some potential combined mechanisms action....
Formerly known as non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic (MASLD) has now become the most widespread chronic worldwide. The primary goal of this study is to assess ability different indexes (including VAI, TyG, HOMA-IR, BMI, LAP, WHtR, TyG-BMI, TyG-WC, and TyG-WHtR) predict MASLD in individuals diagnosed with type 2 diabetes mellitus (T2DM), particularly within Chinese population. This cross-sectional involved 1,742 patients T2DM, recruited from...
Introduction Pregnant women with subclinical hypothyroidism or clinical often exhibit lipid metabolism disorders and are correlated adverse pregnant outcomes. It was suggested that isolated positive thyroid peroxidase antibody (TPOAb) served as a risk factor for However, little known about the profile in TPOAb. The purpose of this prospective observational study to investigate expression profiles among euthyroid TPOAb during there early pregnancy analyze their correlation function. Methods...