A5100614069- Antibiotic Use and Resistance
- Patient Satisfaction in Healthcare
- Healthcare Systems and Reforms
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Patient-Provider Communication in Healthcare
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Infection Control in Healthcare
- COVID-19 and Mental Health
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Pediatric health and respiratory diseases
- Pharmacy and Medical Practices
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical industry and healthcare
- Health disparities and outcomes
- Infection Control and Ventilation
- Hepatitis B Virus Studies
- Medical Research and Treatments
- Global Health Care Issues
- Adolescent and Pediatric Healthcare
- Medication Adherence and Compliance
Hunan University
2024-2025
Huazhong University of Science and Technology
2015-2024
Ministry of Education of the People's Republic of China
2024
Zhengzhou University of Light Industry
2023-2024
Southeast University
2019-2024
Hunan Children's Hospital
2011-2024
Taian City Central Hospital
2012-2024
Qingdao University
2024
Chongqing Medical University
2024
Nanjing Normal University
2000-2024
Discovering new pathways for overcoming multidrug resistance (MDR) of cancer is important to the development chemotherapy. Herein, by mixing metal–phenolic network formed tannic acid and Fe3+ with doxorubicin (DOX)-loaded dendrimer (Den), we prepare Den–DOX–tannic acid–Fe3+ (DDTF) nanocomplex which can combat MDR cells via an apoptosis/ferroptosis hybrid pathway. The elevated reactive oxygen species (ROS) level caused DOX-induced apoptosis sensitizes Fenton reaction-induced ferroptosis...
Aim To assess the impact of National Essential Medicines Policy (NEMP) on use medicines in government-owned primary care institutions Hubei province China. Study design Quasi-experimental and time-trend analysis. Methods A systematic random sampling strategy was employed to select 55 800 prescriptions from 18 organizations who progressively implemented NEMP January 2009 July 2011. We examined change patterns prescriptions. The facilities that at a later stage served as control. Results An...
Abstract Background COVID-19 arise global attention since their first public reporting. Infection prevention and control (IPC) is critical to combat COVID-19, especially at the early stage of pandemic outbreak. This study aimed measure level healthcare workers’ (HCW’) self-reported IPC behaviors with risk emerges increases. Methods A cross-sectional was conducted in two tertiary hospitals. structured self-administered questionnaire delivered HCWs selected The dependent variables were...
Abstract Background Most of the about 140 million informal sector workers in urban China do not have health insurance. A 1998 central government policy leaves it to discretion municipal governments offer cities voluntary participation a social insurance for formal workers, so-called 'basic insurance' (BHI). Methods We used contingent valuation method assess maximum willingness pay (WTP) BHI among including unregistered rural-to-urban migrants, Wuhan City, China. selected respondents...
Over-prescription of antibiotics is prevalent all over the world, contributing to development antibiotic resistance. The importance understanding how physicians prescribe increasingly highlighted for purpose promoting good practice. This study aimed identify factors that shape prescribing behaviors in primary care based on theory planned behavior (TPB).Data were collected from 503 prescribers within 65 facilities Hubei, tapping into four behavioral aspects leading TPB, namely, attitudes (the...
Irrational use of antibiotics is a major driver development antibiotic resistance, which heavily threatens population health worldwide. Understanding the mechanism physician's prescribing decisions increasingly highlighted to promote prudent antibiotics. Therefore, current study aimed fill gap, modelling and identifying potential intrinsic external determinants in primary care.
A [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes was developed to access tetrasubstituted thiophenes.
To assess the prevalence of burnout, secondary traumatic stress, and compassion satisfaction explore their impacts on self-reported hand hygiene among medical aid teams in COVID-19 period Wuhan, China.Cross-sectional study.A total 1,734 healthcare workers from 17 were surveyed. The survey included stress measured by professional quality life scale hygiene. Data collected between 5-7 March 2020. Multiple regression analyses performed.Burnout trauma at low average levels, was high levels....
Astaxanthin (AST) is a compound renowned for its extraordinary antioxidant and anti-inflammatory properties. However, application limited due to low solubility, instability bioavailability. To overcome these drawbacks, we encapsulated AST in liposomes (AST-loaded liposomes, AST-LIP) using chitosan (CS) as coating materials by thin film dispersion high-pressure homogenization. We examined the physicochemical characteristics (particle size, polydispersity index, zeta potential, encapsulation...
To investigate the availability of essential medicines and their prices in Hubei province.The survey assessed using World Health Organization Action International methodology. Data were collected from 18 public hospitals private pharmacies. At each facility 39 innovator brand lowest-price generic equivalent collected. Medicine compared with international reference to obtain a median price ratio (MPR). Daily incomes low average levels used assess affordability medicines.Median sectors was...
Inappropriate use and overuse of antibiotics is a serious concern in the treatment upper respiratory tract infections (URTIs), especially developing countries. In recent decades, information disclosure public reporting (PR) has become an instrument for encouraging good practice healthcare. This study evaluated impact PR on antibiotic prescribing URTIs sample primary care institutions China.A matched-pair cluster-randomized trial was undertaken QJ city, with 20 participating trial....
Differing from previous studies ignoring the nonlinear features, this study employs both linear and Granger causality tests to examine complex causal relationship between health care expenditure economic growth among 15 Organisation for Economic Co-operation Development (OECD) 5 major developing countries. Some interesting findings can be obtained as follows: (1) For Australia, Austria, UK, does not exist them. A unidirectional or running found Ireland, Korea, Portugal, India. these seven...
The overuse of antibiotics has been identified as a major challenge in regard to the rational prescription medicines low and middle income countries. Extensive studies on effectiveness persuasive interventions, such guidelines have undertaken. There is dearth research pertaining effects restrictive interventions. This study aimed evaluate impacts restrictions relation types administration routes antibiotic procurement primary care settings China.Data were drawn from monthly records for...
The aim of this paper is to measure the knowledge and attitudes primary care physicians toward antibiotic prescriptions their impacts on prescribing. A questionnaire survey was conducted 625 from 67 facilities in Hubei, China. Structural equation modelling (SEM) applied test theoretical framework derived Knowledge, Attitudes, Practices (KAP) theory. Physicians’ knowledge, five sub-types attitudes, three behavioral intentions towards use were measured. Physicians had limited about (average...
Pyridinium 1,4-zwitterionic thiolates, as a novel kind of sulfur-containing synthon, have been applied to the synthesis 12aH-benzo[f]pyrido[1,2-d][1,4]thiazepines and benzo[b]thiophenes. Benzopyridothiazepines were produced through 1,5-dipolar cycloaddition reaction from pyridinium thiolates with arynes, whereas benzothiophenes side products generated via [3 + 2] cascade cyclization reaction. The [5 mode is disclosed for first time.
The synthesis of pyridothiazines was achieved using pyridinium 1,4-zwitterionic thiolates and α-functionalized bromoalkanes via a formal [5+1] pathway. Further studies demonstrated that the indolizines could be accomplished stepwise [(5+1)-1] pathway with unstable as transient intermediates from same starting materials. net transformation involves sequence annulation, oxidation ring-contraction/desulfuration.
Abstract Heterocycles 2-pyridone and uracil are privileged pharmacophores. Diversity-oriented synthesis of their derivatives is in urgent need medicinal chemistry. Herein, we report a palladium/norbornene cooperative catalysis enabled dual-functionalization iodinated 2-pyridones uracils. The success this research depends on the use two unique norbornene as mediator. Readily available alkyl halides/tosylates aryl bromides utilized ortho -alkylating -arylating reagents, respectively. Widely...
This study aimed to determine the association between factors relevant diagnostic uncertainty and physicians' antibiotic-prescribing behaviour in primary care. A questionnaire survey was conducted on 327 physicians that measured their ability, perceived frequency of uncertainty, tolerance, patient tolerance uncertainty. Physician behaviours were assessed based prescriptions (n = 207,804) three conditions: upper respiratory tract infections (URTIs, antibiotics not recommended), acute...
Abstract As dominant regulators of osteoclastogenesis and bone resorption, receptor activator NFκB (RANK), ligand, OPG have been identified as ideal drug targets for the treatment metabolic disease. One concern regarding therapeutic use RANK signaling inhibitors is their effect on fracture healing. Therefore we tested if uncoupling osteoclast depletion via blockade affects callus formation, maturation matrix remodeling, well union rates in a mouse tibia model. Low dose (1 mg/kg i.p.) RANK:Fc...
The World Health Report 2000 stated that increased public financing for healthcare was an integral part of the efforts to achieve equity access. In 2009, Chinese government launched a three-year health reform program Through this program, intended increase its investment in primary institutions (PHIs). However, reports about outcome and improvement access have yet be presented. Stratified sampling employed research. samples used study comprised 34 community service centers (CHSCs) 92...