A5033707375- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Bone Tissue Engineering Materials
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- High-Temperature Coating Behaviors
- Nanoplatforms for cancer theranostics
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related gene regulation
- High Temperature Alloys and Creep
- Hepatitis C virus research
- Geotechnical Engineering and Underground Structures
- Bladder and Urothelial Cancer Treatments
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Maastricht University
2021-2025
China Pharmaceutical University
2023-2024
Shanghai Ocean University
2024
Fuda Cancer Hospital
2024
Guilin University of Technology
2020-2023
Hangzhou Normal University
2021-2023
Second Affiliated Hospital of Zhejiang University
2022-2023
Union Hospital
2021-2023
PURPOSE Lenvatinib (LEN) is a first-line therapy for patients with advanced hepatocellular carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to compare clinical outcomes of LEN combined transarterial chemoembolization (LEN-TACE) versus monotherapy in HCC. MATERIALS AND METHODS This was multicenter, randomized, open-label, parallel group, phase III trial. Patients primary treatment-naive or initial recurrent HCC after surgery were randomly assigned (1:1)...
Abstract A comprehensive cellular anatomy of normal human kidney is crucial to address the origins renal disease and cancer. Some diseases may be cell type-specific, especially tubular cells. To investigate classification transcriptomic information kidney, we rapidly obtained a single-cell suspension conducted RNA sequencing (scRNA-seq). Here, present scRNA-seq data 23,366 high-quality cells from kidneys three donors. In this dataset, show 10 clusters Due high quality information, proximal...
Abstract There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC). It necessary to investigate the therapeutic efficacy safety of TACE combined with PD-(L)1 inhibitors MTT real-world situations. In this nationwide, retrospective, cohort study, 826 HCC patients receiving either plus blockades (combination group, n = 376) or monotherapy...
Abstract Programmed cell death protein-1 (PD-1)/programmed ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover nucleophosmin (NPM1) binds to promoter specifically TNBC cells and activates transcription, thus inhibiting T activity vitro vivo. Furthermore, demonstrate PARP1 suppresses transcription through its with the nucleic acid binding...
Macroporous biphasic calcium phosphate (BCP) with channel-shaped pores was produced by a novel dual-phase mixing method. The processing route includes water-based BCP slurry and polymethylmethacrylate resin; shaping in mold; polymerization, drying, pyrolyzing, sintering. After comparison two other commercial macroporous materials, which were along different routes, it found that conventional parameters such as porosity pore size cannot describe structure precisely enough for the application...
Abstract Extracellular vesicles (EVs) hold great promise for transporting CRISPR–Cas9 RNA-guided endonucleases (RNP) throughout the body. However, cell-selective delivery of EVs is still a challenge. Here, we designed valency-controlled tetrahedral DNA nanostructures (TDNs) conjugated with aptamer, and loaded TDNs on EV surface via cholesterol anchoring specific cell targeting. The targeting efficacy different ratios aptamer/cholesterol from 1:3 to 3:1 in decorating was investigated. one...
Significance Statement Previous studies of bladder cell classification mostly relied on the cell’s morphology, location, electrophysiology, and function. However, it is difficult to classify cells accurately comprehensively using these methods. The authors created a single-cell transcriptomic map human RNA sequencing. They also more detailed sequencing mouse than what was previously available. Using tools, compare similarities differences between found many types that are highly similar...
Rice at reproductive stage is more sensitive to environmental changes, and little known about the mechanism of heat response in rice panicle. Here, using microarray, we provided a time course gene expression profile panicle anther developmental 8 after 40°C treatment for 0 min, 20 60 2 h, 4 h. The identified differentially expressed genes were mainly involved transcriptional regulation, transport, cellular homeostasis, stress response. predominant transcription factor families responsive...
It remains controversial whether tumour mutational burden (TMB) or neoantigens are prognostic markers in hepatocellular carcinoma (HCC). This study aimed to define the function of TMB antitumour immunotherapy.Neoantigens patients (n=56) were analysed by pVAC tools with major histocompatibility complex-1 (MHC-I) algorithms based on whole exome sequencing and mutant type IC50 <50 nM defined as high-affinity (HANs). Patients segregated into HAN-high/low groups median HAN value, overall survival...
CD39, expressed by tumor-infiltrating lymphocytes (TILs), is a marker to identify tumor-reactive T cells, which frequently associated with stronger antitumor activity than bystander cells in variety of malignancies. Therefore, CD39 could be promising for identifying the active immune used cellular immunotherapy. To test this possibility, we constructed hepatitis B virus (HBV) surface protein-specific chimeric antigen receptor (HBVs-CAR-T cells) and generated personalized CD8+ cells. We...
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Patient‐derived organoid (PDO) has great potential in precision oncology, but low success rate, time‐consuming culture, and lack tumor microenvironment (TME) limit its application. Mesenchymal stromal cells (MSC) accumulate primary site to support growth recruit immune form TME. Here, MSC peripheral blood mononuclear (PBMC) coculture used construct HCC organoid‐on‐a‐chip mimicking original TME provide a...
Abstract Introduction Adipose derived mesenchymal stem cells (ADMSCs), carrying the similar characteristics to bone marrow cells, only much more abundant and easier obtain, may be a promising treatment for liver fibrosis. We aim investigate therapeutic potential of ADMSCs transplantation in fibrosis caused by carbon tetrachloride (CCl 4 ) rats as well its underlying mechanism, further explore appropriate infusion pathway. Methods were isolated, cultured identified. Placebo transplanted via...
Purpose To evaluate whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) predict survival metastasis in patients after transarterial chemoembolization (TACE) for recurrent hepatocellular carcinoma (RHCC). Materials Methods Clinical laboratory data from 132 RHCC treated with TACE January 2003 to December 2012 were retrospectively reviewed. Prognostic factors assessed by multivariate analysis, the predictive values of NLR PLR overall (OS) extrahepatic metastases...
Abstract Background. The survival benefit of combining sorafenib and transarterial chemoembolization (TACE) therapy compared with monotherapy for patients advanced hepatocellular carcinoma (HCC) main portal vein tumor thrombosis (MPVTT) is unclear. Methods. Between January 2009 June 2013, 183 consecutive HCC (Barcelona Clinic Liver Cancer stage C) MPVTT were retrospectively reviewed. Of these, 89 enrolled in this study: 45 treated combination (sorafenib-TACE group), the other 44 (sorafenib...
Abstract Introduction. This study evaluated long-term outcomes of salvage surgery as additional therapy following downstaging hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) in patients initially unresectable HCC. Methods. A retrospective analysis was performed 831 consecutive HCC who underwent TACE initial treatment between June 2004 and December 2014. Of these, 82 downstaged resectable were enrolled this study: 43 received (S group) the remaining 39, refused...
Purpose To retrospectively investigate the safety and efficacy of sorafenib combined with transarterial chemoembolization (TACE) radiofrequency ablation (RFA) (hereafter, TACE-RFA) in treatment recurrent hepatocellular carcinoma (rHCC) portal vein tumor thrombosis, extrahepatic metastases (advanced carcinoma), or both after initial hepatectomy. Materials Methods The study was centrally approved by ethics committee three tertiary medical centers China. From January 2010 to 2015, 207...
Natural bone is a complex composite, consisting predominantly of collagen and hydroxyapatite (HA), which form highly organized, hierarchical structure from the nano- to macroscale. Because its biphasic, anisotropic, ultrafine structural design, tissue possesses excellent mechanical properties. Herein, inspired by composition microstructure natural bone, biphasic composite aligned strontium/copper-doped one-dimensional (Sr/Cu-doped 1D HA) poly(d,l-lactide) (PDLA) was developed. The presence...