A5102995074- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Cancer Research and Treatments
- Geochemistry and Geologic Mapping
- Cancer, Lipids, and Metabolism
- Geological and Geochemical Analysis
- Nausea and vomiting management
- Pathogenesis and Treatment of Hiccups
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Health Systems, Economic Evaluations, Quality of Life
Sun Yat-sen University
2015-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Key Laboratory of Guangdong Province
2020-2024
Institute of Cancer Research
2022-2024
Institute of Cancer Research
2022
Hebei GEO University
2005-2021
University of Bonn
2021
Third Affiliated Hospital of Guangzhou Medical University
2020
Guangzhou Medical University
2020
Xiangya Hospital Central South University
2012
Abstract Programmed cell death protein-1 (PD-1)/programmed ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover nucleophosmin (NPM1) binds to promoter specifically TNBC cells and activates transcription, thus inhibiting T activity vitro vivo. Furthermore, demonstrate PARP1 suppresses transcription through its with the nucleic acid binding...
Background: In the CASPIAN trial, durvalumab + chemotherapy demonstrated significant improvements in overall survival compared with alone patients extensive-stage small cell lung cancer (SCLC). We aimed to assess cost-effectiveness of SCLC from US healthcare system perspective. Patients and Methods: A comprehensive Markov model was adapted evaluate cost effectiveness combination versus platinum/etoposide first-line therapy based on data study. The main endpoints included total costs, life...
Abstract Background PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was novel transcriptional regulator PD-L1 and stimulated the transcription PD-L1, underlying regulatory mechanism remains incompletely characterized. Methods Various human cancer cell lines were used to validate regulating PD-L1. The acetyltransferase NAT10 identified facilitator acetylation by coimmunoprecipitation mass spectrometry....
The role of neoadjuvant chemotherapy (NAC) in colon cancer remains unclear. This trial investigated whether 3 months modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or capecitabine (CAPOX) as NAC could improve outcomes patients with locally advanced versus upfront surgery.
EphA2 is a crucial oncogene in gastric cancer (GC) development and metastasis, this study aims to identify microRNAs that target it serve as key regulators of carcinogenesis. We identified several potential targeting by bioinformatics websites then analyzed the role miR-302b modulating vitro vivo GC, it's mechanism. Our analysis miR-302b, novel regulator EphA2, one most significantly downregulated microRNA (miRNA) GC tissues. Overexpression impaired cell migratory invasive properties...
Background: The CheckMate 227 trial has indicated that nivolumab plus ipilimumab compared with chemotherapy significantly increases long-term survival in the first-line setting of advanced non-small-cell lung cancer (NSCLC). Methods: A Markov model was built to estimate cost and effectiveness vs. as therapy patients NSCLC based on outcomes data from trial. We calculated health at a willingness-to-pay (WTP) threshold $150,000 per quality adjusted life year (QALY) populations different...
Abstract Purpose This trial evaluated the addition of cetuximab to a modified FOLFOXIRI (mFOLFOXIRI: 5-fluorouracil/folinic acid, oxaliplatin, irinotecan) as conversion therapy in two-group, nonrandomized, multicenter, phase II patients with initially technically unresectable colorectal liver-limited metastases (CLM) and BRAF/RAS wild-type. Patients Methods were enrolled receive (500 mg/m2) plus mFOLFOXIRI (oxaliplatin 85 mg/m2, irinotecan 165 folinic acid 400 5-fluorouracil 2,800 mg/m2...
Abstract Purpose: Immune checkpoint inhibitors (ICI) have become the standard of care for patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer. However, biomarkers response to ICI are still lacking. Experimental Design: Forty-two dMMR cancer treated neoadjuvant PD-1 blockade were prospectively enrolled. To identify pathologic complete (pCR) therapy, we analyzed genomic and transcriptomic profiles based on next-generation sequencing, immune...
3500 Background: Adjuvant chemotherapy is the recommended standard treatment for resected stage III and high-risk II colon cancer, but disease recurrence remain common. Perioperative has proved effective in several tumors, not cancer. We aimed to assess whether perioperative could improve outcomes patients with locally advanced Methods: In this multicenter, randomized, phase 3 trial, participants were recruited from 28 hospitals China. Eligible aged 18-75 years, had a adenocarcinoma,...
Abstract Background Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learning (DL) model based on the pre-treatment CT images for predicting MMR CRC. Methods 1812 eligible participants (training cohort: n = 1124; internal validation 482; external 206) CRC were enrolled from two institutions. All pretherapeutic three dimensions trained by...
The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant has been developed and predictive value explored patients with elevated CEA levels (> 5 ng/mL). training cohort was derived from FOWARC prospective phase III trial, 71/483 eligible included. validation consisted of 75/587 consecutive Xiangya Hospital between 2014 2015. kinetic changes serum measured at...
The clinical trial of Keynote-604 showed that pembrolizumab plus chemotherapy could generate benefits for extensive-stage small-cell lung cancer (ES-SCLC). We aim to assess the efficacy and cost combined with in first-line treatment setting ES-SCLC from United States (US) payers' perspective.A synthetical Markov model was used evaluate effectiveness platinum-etoposide(EP) versus EP therapy data Keynote-604. Lifetime costs life-years(LYs), quality adjusted LYs(QALYs) incremental...
Preoperative fluoropyrimidine with radiotherapy was regarded as the standard of care for locally advanced rectal cancer (LARC). The model predicting pCR in LARC patients based on treatment only. This study aimed to establish a nomogram pretherapeutic parameters and different neoadjuvant regimens pathologic complete response (pCR) tumor downstaging or good (ypT0-2N0M0) after receiving randomized clinical trial.Between January 2011 February 2015, 309 were enrolled from prospective...
We examined the predictive value of mismatch repair (MMR) status in relation to responses neoadjuvant therapy and prognosis locally advanced rectal cancer patients.A total 854 consecutive patients with MMR who underwent followed by curative surgery between January 2013 December 2018 were included this retrospective study. was determined an analysis protein expression immunohistochemistry (IHC). Propensity score matching performed reduce imbalances baseline characteristics. The categorical...
Objective: To estimate the cost-effectiveness of utidelone plus capecitabine therapy compared to alone in patients with metastatic breast cancer (MBC) resistant anthracyclines and taxanes treatment Chinese context provide a reference for marketing China. Methods: A Markov model was developed based on NCT02253459 clinical trial simulate course who had received anthracycline therapy. The quality-adjusted life years (QALYs) Incremental Cost Effectiveness Ratio (ICER) were then analyzed evaluate...
The current study aims to compare the application and convenience of upper arm port with other two methods implanted ports in jugular vein subclavian patients gastrointestinal cancers.Currently, standard practice is placement central venous access via an internal approach. Perioperative time, postoperative complications, comfort level receiving were retrospectively compared those from April 2013 November 2014.Three hundred thirty-four are recruited for this analysis, consisting 107 group, 70...
The encouraging effects of HER2-ADC in patients with HER2-low expression cancers indicated the classical classifications based on positive and negative HER2 might no longer be suitable. However, biology prognosis colorectal cancer different status were still not clear. This is a multi-center retrospective study that included histologically confirmed determined who received radical surgical resection. immunohistochemistry (IHC) 1+ IHC 2+ groups combined defined as group because concordance...