A5102963642- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Heat shock proteins research
- Colorectal Cancer Screening and Detection
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cellular Mechanics and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Amoebic Infections and Treatments
- Hippo pathway signaling and YAP/TAZ
- Inflammatory Biomarkers in Disease Prognosis
- S100 Proteins and Annexins
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Viral Infections and Vectors
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
North China University of Science and Technology
2024
In-Q-Tel
2012
Abstract Background Colorectal cancer (CRC) has high incidence and mortality rates, with severe prognoses during invasion metastasis stages. Despite advancements in diagnostic therapeutic technologies, the impact of tumour microenvironment, particularly extracellular matrix (ECM) stiffness, on CRC progression is not fully understood. Methods This study included 107 patients. Tumour stiffness was assessed using magnetic resonance elastography (MRE), collagen ratio analysed Masson staining....
Intrinsic and acquired resistance to targeted therapies is a significant clinical problem in cancer. We previously showed that regorafenib, multi-kinase inhibitor for treating colorectal cancer (CRC) patients, can be caused by mutations the tumor suppressor
The role of neoadjuvant chemotherapy (NAC) in colon cancer remains unclear. This trial investigated whether 3 months modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or capecitabine (CAPOX) as NAC could improve outcomes patients with locally advanced versus upfront surgery.
Exposure to arsenic in individuals has been found be associated with various health-related problems including skin lesions, cancer, and cardiovascular immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main active polyphenolic catechin present green tea, shown potent antioxidant, anti-apoptotic anti-inflammatory activity vivo vitro. Thus, study was conducted investigate protective effects of EGCG against arsenic-induced inflammation immunotoxicity mice.Serum IL-1β, IL-6...
Matrix stiffness is an essential physical microenvironment in solid cancer. However, its influence on cancer stemness still remains elusive. Colorectal (CRC) cell line HCT-116 was cultured the matrix with various stiffness. The siYAP applied to detect changes of markers. markers, Yes-associated protein (YAP), Lamin A/C and downstream molecules, their activation were measured after treatment anti-β1-integrin FAK inhibitors. In CRC tissue samples, collagen deposition expression α-SMA CD133...
Abstract Background Total mesorectal excision following neoadjuvant chemoradiotherapy (nCRT) is recommended in the latest treatment of locally advanced rectal cancer (LARC). Objective To predict whether patients with LARC can achieve pathologic complete response (pCR), comparing MRI‐based radiomics between before and after radiotherapy (nRT) was performed. Methods One hundred sixty‐five features axial T2‐weighted images were obtained quantitatively from Imaging Biomarker Explorer Software....
Propranolol suppresses tumor growth in a variety of preclinical solid models, with number proposed cell signaling and immunological mechanisms. We want to confirm the potential mechanisms, including reduced phosphorylation AKT/MAPK pathways, as well enhanced CD8 + T‐cell–mediated antitumor immune response. To clarify mechanism propranolol activity colorectal cancer, therapeutic was then assessed CT26WT tumors engrafted BALB/C mice. Then effect treatment also examined by randomizing patients...
The aim of this study was to analyse the landscape publications on rectal cancer (RC) over past 25 years by machine learning and semantic analysis.Publications indexed in PubMed under Medical Subject Headings (MeSH) term 'Rectal Neoplasms' from 1994 2018 were downloaded September 2019. R Python used extract publication date, MeSH terms abstract metadata each for bibliometric assessment. Latent Dirichlet allocation applied text articles' abstracts identify more specific research topics....
Previous studies demonstrated that several inflammation-based hematological indices are closely related to various malignancies, including colorectal cancer (CRC). In this study, the prognostic value of markers, a combination index termed coNLR-PDW, comprising preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet distribution width (PDW), was evaluated in 206 patients with non-metastatic CRC treated surgery at single medical center. The association patient demographics, blood...
Colorectal cancer (CRC) has become a major public health problem, ranking as the third most common type of cancer. Our previous study revealed that TCF21 is frequently silenced by promoter hypermethylation in both CRC cell lines and primary CRC, with methylation being significantly correlated lymph node invasion. In this study, we further analyze expression tissues investigate role vitro vivo. We also explore possible pathway regulated TCF21. thus demonstrate decreased levels are associated...
3500 Background: Adjuvant chemotherapy is the recommended standard treatment for resected stage III and high-risk II colon cancer, but disease recurrence remain common. Perioperative has proved effective in several tumors, not cancer. We aimed to assess whether perioperative could improve outcomes patients with locally advanced Methods: In this multicenter, randomized, phase 3 trial, participants were recruited from 28 hospitals China. Eligible aged 18-75 years, had a adenocarcinoma,...
Abstract In our study, we for the first time assessed association of galectin‐7 and S100A9 with clinicopathological variables survival outcomes in cervical squamous carcinoma patients explored underlying molecular mechanisms cell lines. Immunohistochemical analysis 243 patient samples showed that positive staining rate gradually decreased from normal tissue to intraepithelial neoplasia carcinoma. Both significant negative lymph node metastasis staging Cervical or significantly lower 5‐year...
Neuron navigator 2 (NAV2) encodes a member of the neuron gene family, which plays role in tumorigenesis and cell migration. However, prognostic value NAV2 expression colorectal cancer (CRC) patients potential pathway through promotes migration invasion CRC lines is poorly understood. The level was detected tissues from two different cohorts by immunohistochemistry, qRT-PCR Western blotting; correlation between clinicopathological characters analyzed, analyzed using Cox regression model. with...
The postoperative survival of patients with stage III colorectal cancer (CRC) various obviously. We sought to develop novel nomograms for predicting the these after radical surgery and chemotherapy. A total 620 consecutive CRC who underwent curative resection chemotherapy between January 2009 December 2015 were retrospectively collected randomly allocated training (n = 372) or validation cohort 248). Clinicopathological factors analyzed. On basis data from 372 in set, predictive overall (OS)...
Purpose: The aim of this study was to evaluate the diagnostic value S100A9 and tenascin-c (TNC) levels as colorectal cancer (CRC) biomarkers in several ways, including through screening tests, differentiation combination with existing (CEA CA19-9), serum level measurements before after surgery. Materials Methods: In case-control study, TNC were measured 460 participants: 258 CRC patients, 99 patients benign colonic disease (BCD) 103 healthy donors (HD). Results: 22.32 (14.88-29.55) ng/ml,...
Concurrent chemoradiotherapy (CCRT) is recently recommended as the primary and standard treatment modality for cervical cancer. The aim of this study to investigate protein biomarkers associated with CCRT sensitivity, so better understand mechanisms underlying resistance. Fresh tumor tissues from five cases each group CCRT-highly sensitive (CCRT-HS) CCRT-lowly (CCRT-LS) were analyzed by 2-D electrophoresis coupled MALDI-TOF-MS, followed Western blot four candidate proteins including S100A9,...
Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and therefore considered an oncogene. However, the role of TXNDC5 CRC tumorigenesis remains unclear. The present study aimed to explore vitro vivo under hypoxic normoxic conditions. Analyses patient tissue samples revealed a positive association between expression hypoxia‑inducible factor‑1α (HIF‑1α) or TNM stage CRC. In addition, correlation levels HIF‑1α was observed tissues. Furthermore,...
Background: Colorectal cancer (CRC) ranks as the third most frequent type and second leading cause of cancer-related death worldwide.The liver is common metastatic site CRC with 20%-34% patients suffering synchronous metastasis.Patients colorectal liver-limited metastasis account for one-third deaths from cancer.Moreover, some evidence indicated that disease encounter a worse prognosis more disseminated state comparing develops metachronously.Methods: Data in this retrospective analysis were...
Purpose: To identify the clinical predictive factors of tumor response and to evaluate significance primary gross volume (pGTV), obtained from radiotherapy planning, in predicting response. Materials Methods: We retrospectively analyzed data consecutive locally advanced rectal cancer (LARC) patients who were treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery at our institution between March 2009 December 2017. independent predictors nCRT statistical analysis....
The aim of the present study is to profile differentially expressed protein markers between left-sided colon cancer (LSCC) and right-sided (RSCC). Fresh tumor tissue samples from LSCC (n = 7) RSCC groups were analyzed by two-dimensional electrophoresis coupled with MALDI-TOF-MS, followed Western blotting. In 50 paraffin embedded each group, levels four proteins (identified proteomics analysis) measured microarray immunohistochemistry staining compare different RSCC. Sixteen found be Ten...