A5041587792- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Vibration Control and Rheological Fluids
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Cell Image Analysis Techniques
- Autophagy in Disease and Therapy
- Characterization and Applications of Magnetic Nanoparticles
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Wind and Air Flow Studies
- Dynamics and Control of Mechanical Systems
- Structural Engineering and Vibration Analysis
- Effects of Vibration on Health
- Vehicle Noise and Vibration Control
- Belt Conveyor Systems Engineering
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Helicobacter pylori-related gastroenterology studies
Central South University
2015-2024
Xiangya Hospital Central South University
2016-2024
Second Xiangya Hospital of Central South University
2021-2024
Hunan Normal University
2019-2024
Hunan Provincial People's Hospital
2019-2024
Wuhan Polytechnic University
2009-2020
Changsha Hospital for Maternal and Child Health Care
2017
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). The present study aims at exploring the biological role of lncRNA plasmacytoma variant translocation 1 (PVT1) OA and underlying mechanism. Results showed that expression PVT1 was upregulated chondrocytes compared with normal chondrocytes, silencing inhibited apoptosis overexpression promoted chondrocytes. To further investigate mechanism, miR-488-3p predicted a targeted...
Alzheimer’s disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote longevity, but a protective effect GLTs on AD damage not yet reported. The objective this research was elucidate phylactic model mice cells explore its underlying mechanisms. Morris water maze (MWM) test conducted detect changes in cognitive function mice. Hematoxylin-eosin (HE) staining applied observe...
Exposure to arsenic in individuals has been found be associated with various health-related problems including skin lesions, cancer, and cardiovascular immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main active polyphenolic catechin present green tea, shown potent antioxidant, anti-apoptotic anti-inflammatory activity vivo vitro. Thus, study was conducted investigate protective effects of EGCG against arsenic-induced inflammation immunotoxicity mice.Serum IL-1β, IL-6...
ABSTRACT Signal transducers and activators of transcription 1 (STAT1) exhibits tumor‐suppressor properties by inhibiting oncogenic pathways promoting tumor immunosurveillance. MicroRNAs, a group non‐coding endogenous ones, may regulate gene expression plays specific roles in tumorigenesis. Recently, miR‐181a has been reported to be associated with poor prognosis colorectal cancer (CRC). Using human cell lines, we demonstrated that STAT1 suppresses both LoVo SW480 growth down‐regulating...
Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol a Chinese medicinal herb traditionally used as cancer remedy. However, molecular mechanisms underlying anticancer activity curcumol in melanoma remains largely unknown. In present study, we observed that decreased mouse B16 cell proliferation migration. The xenograft tumor assay showed reduced volume lung metastasis. upregulated expression E-cadherin downregulated N-cadherin, MMP2 MMP9 cell. Western blot...
Previous studies demonstrated that several inflammation-based hematological indices are closely related to various malignancies, including colorectal cancer (CRC). In this study, the prognostic value of markers, a combination index termed coNLR-PDW, comprising preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet distribution width (PDW), was evaluated in 206 patients with non-metastatic CRC treated surgery at single medical center. The association patient demographics, blood...
Background: Hepatocellular carcinoma (HCC) is a particularly prevalent type of liver cancer and one the deadliest malignancies in Asia. Tangeretin biological compound extracted from traditional Chinese herbs has been shown to have potential antitumour properties; however, its mechanism remains largely unknown. Therefore, we sought determine role HepG2 cells subjected treatment. Materials methods: Cell proliferation was quantified using CCK-8, EdU colony formation assays, cell migration...
Neuron navigator 2 (NAV2) encodes a member of the neuron gene family, which plays role in tumorigenesis and cell migration. However, prognostic value NAV2 expression colorectal cancer (CRC) patients potential pathway through promotes migration invasion CRC lines is poorly understood. The level was detected tissues from two different cohorts by immunohistochemistry, qRT-PCR Western blotting; correlation between clinicopathological characters analyzed, analyzed using Cox regression model. with...
Laparoscopic natural orifice specimen extraction surgery (NOSES) has been widely used in colorectal neoplasms. However, only a few studies have focused on robotic NOSES. This study compared the short-term clinical outcomes and long-term survival between NOSES conventional resection (CRR) groups.From March 2016 to October 2018, consecutive of 143 patients who underwent sigmoid rectal at Department Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, were considered...
Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and therefore considered an oncogene. However, the role of TXNDC5 CRC tumorigenesis remains unclear. The present study aimed to explore vitro vivo under hypoxic normoxic conditions. Analyses patient tissue samples revealed a positive association between expression hypoxia‑inducible factor‑1α (HIF‑1α) or TNM stage CRC. In addition, correlation levels HIF‑1α was observed tissues. Furthermore,...
Abstract Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in induced by drugs, toxins, and other etiologies, the effective treatment for ALF very limited. Among drug-induced ALF, acetaminophen (APAP) overdose most common cause. However, molecular mechanisms underlying APAP hepatoxicity remain incompletely understood. Sirtuin 6 (Sirt6) stress responsive protein deacetylase plays an important role regulation of DNA repair, genomic stability, oxidative stress,...
Background: Inducible nitric oxide synthase (iNOS) has supposed to implicate in inflammation, infection, liver cirrhosis, and neoplastic diseases. This study was designed explore the biological clinical function of iNOS intrahepatic cholangiocarcinoma (ICC). Methods: RT-PCR (Real-time quantitative PCR) immunohistochemical staining were used analyze expression ICC adjacent tissues. CCK8, transwell assays, flow cytometry conducted detect proliferation, apoptosis, cell cycle. Western blotting...
Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease of the pancreas. Reactive oxygen species (ROS) play key role in occurrence development AP. With increasing ROS levels, degree oxidative stress severity AP increase. However, diagnosing still has many drawbacks, including difficulties with early diagnosis undesirable sensitivity accuracy. Herein, we synthesized semiconducting polymer nanoplatform (SPN) that can emit ROS-correlated chemiluminescence (CL)...
// Qian Pei 1 , Hong Zhu 2 Fengbo Tan Nanhui Yu Zhongyi Zhou Yuan Xiangping Song Yuqiang Li Yiming Tao 3 Sai Zhang 4 Liling 5 Qingling and Haiping Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China Oncology, General Institute Medical Sciences, Pathology, Correspondence to: Pei, email: Keywords : intravascular emboli, stage III colorectal cancer, prognosis, clinicopathological characteristics, CD133 Received April 18, 2016 Accepted July 28,...
Background: Protein phosphatase magnesium-dependent 1 delta (PPM1D), also referred to as wild-type p53-induced (Wip1) or protein 2C (PP2Cδ), is an oncogenic nuclear serine/threonine belonging the PP2C family. However, knowledge regarding PPM1D mRNA expression, tumor immunity, and prognosis in hepatocellular carcinoma (HCC) scanty. Methods: We analyzed PPM1D, including its expression both normal tissue using Sangerbox database Tumor Immune Estimation Resource (TIMER). evaluated correlation...
In our previous study, we revealed that Cyclosporin A (CsA) could inhibit miR-144 expression to regulate proliferation and invasion of human trophoblast (HT) cells through targeting titin. This partially demonstrated the mechanism by which CsA promotes titin increase vitality HT cells. However, inhibits remains be investigated. Recently, interaction between lncRNA miRNA has been frequently reported play major role in several biological processes. present online tools were used figure out...
Purpose: E3 ubiquitin ligase ZNRF3 is linked to the pathogenesis of diseases and tumorigenesis. The present study aims explore expression its association with prognostic survival human colorectal carcinoma. Methods: A follow-up survey 168 patients carcinoma was performed, specimens tissues were collected for immunohistochemistry Western blotting analyses. Furthermore, overexpression using transient transfection recombinant pEGFP-ZNRF3 plasmid detection apoptosis proliferation performed in...
Macrophage migration inhibitory factor (MIF) has been shown to promote disease progression in many malignancies, including multiple myeloma (MM). We previously reported that MIF regulates MM bone marrow homing and knockdown of favors the extramedullary formation mice. Here, based on immunostaining cells paired intramedullary biopsies from 17 patients, we found lower intensity (EMM) versus (IMM). Flow cytometry histology analysis xenograft models showed a portion inoculated human lost their...
// Nanhui Yu 1, 2 , Hong Zhu 1 Yuan Yang 3 Yiming Tao Fengbo Tan Qian Pei Zhou Xiangping Song Qiurong and Haiping Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, P.R. China Pharmacy, Hospital for Maternal Child Health Care, 410007, Dong Medicine Key Laboratory Hunan Province, medicine, University Medicine, 418000, Correspondence to: Pei, email: haiping1977pei@163.com Keywords: combination Fe/Cu –chelators docosahexaenoic acid, myeloid cell...
This paper investigates a type of linear vibration isolator which incorporates two passive devices, negative stiffness elements and an inerter, into the conventional (massstiffnessdamper). Two configurations devices are considered, respectively: (1) direct parallel connection inerter element; (2) series with viscous damper, which, together, is then connected element in parallel. Numerical evaluations presented for isolators subject to base harmonic shock excitation, terms natural frequency,...
Abstract In this study, we devised a computational framework called Supervised Feature Learning and Scoring (SuperFeat) which enables the training of machine learning model evaluates canonical cellular statuses/features in pathological tissues that underlie progression disease. This also identification potential drugs target presumed detrimental features. was constructed on basis an artificial neural network with gene expression profiles serving as input nodes. The data comprised single-cell...
The key to realize tractor visual navigation was obtained the actual three-dimensional coordinates of corresponding points on captured image. So camera used capture tracks must be calibrated. In order solve above problem, a calibration algorithm for vision proposed. which can meet high real-time requirements simple and accurate. average error using this 0.149157 pixels, distortion coefficient 0.184473, less than one thousandth.