A5101999891- Traditional Chinese Medicine Studies
- Hematopoietic Stem Cell Transplantation
- Traditional Chinese Medicine Analysis
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Ginseng Biological Effects and Applications
- Medical Research and Treatments
- Plant-based Medicinal Research
- Respiratory Support and Mechanisms
- Natural product bioactivities and synthesis
- Autoimmune Neurological Disorders and Treatments
- Chinese history and philosophy
- Healthcare and Venom Research
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Central Venous Catheters and Hemodialysis
- Pancreatitis Pathology and Treatment
- Ion Transport and Channel Regulation
Beijing University of Chinese Medicine
2014-2025
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Kunming Medical University
2020-2025
Sun Yat-sen University
2019-2025
Chinese PLA General Hospital
2019-2024
Chinese People's Liberation Army
2021-2024
Beijing Jiaotong University
2024
Hunan Normal University
2022-2024
First Affiliated Hospital of Zhengzhou University
2015-2024
Chongqing Medical University
2017-2024
Cholangiocarcinoma (CCA) is a malignant tumor originating in the bile duct and its branching epithelium. Due to high heterogeneity, there are no specific clinical indications at early stage, diagnosis often advanced CCA. With surgical resection, 5-year postoperative survival rate (long-term rate) very poor. The regimen of gemcitabine combined with platinum has been used as first-line chemotherapy for patients. In recent years, targeted therapy variety tumors made great progress, showing good...
Abstract Background Cardiovascular disease (CVD) encompasses an array of cardiac and vascular disorders, posing a significant threat to global health. It remains unclear whether there exists association between triglyceride-glucose index (TyG) its derived indices the incidence cardiovascular disease, in particular, strength populations with different glucose metabolisms is not known. Methods Data extracted from National Health Nutrition Examination Survey (NHANES) covering period 1999 2020,...
Abstract The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs (miRNAs) crucial biological regulators that act by suppressing their target genes and involved in a variety pathophysiologic processes. miR-127 appears to be downregulated during injury. We set out investigate the role inflammation. Expression significantly reduced cytokine release macrophages. Looking into regulation inflammation miR-127, we found IgG FcγRI (CD64) was as evidenced CD64 protein...
Non-alcoholic fatty liver disease (NAFLD) has become a major cause of chronic disease. The Chinese herbal medicine (CHM) Dachaihu decoction (DCHD) been proved to treat NAFLD with good efficacy in previous studies. Based on the TCM principle formula formation, we divided DCHD into soothing part, invigorating spleen and dredging intestine part. Marshall officially proposed concept "intestinal-hepatic axis", which systematically explains interactions between liver. We hypothesized that effect...
Chondrosarcoma, the second-most frequent primary bone malignancy, is generally more resistant to conventional chemotherapy and radiotherapy. Therefore, development of an effective adjuvant therapy necessary. Recently, targeting epigenetic regulator such as bromodomain extraterminal domain (BET) proteins has achieved great success. For instance, inhibitor JQ1 been shown inhibit growth several cancer cells both in vitro vivo. Herein, we demonstrated that significantly inhibited chondrosarcoma...
Gap balancing is a vital process during mobile-bearing unicompartmental knee arthroplasty (MB-UKA). However, this commonly depends on the surgeon's experience and lacks specific unified standards. This study aimed to propose evaluate novel "measured resection" method for gap balance in MB-UKA. prospective included 49 consecutive patients (52 knees) who underwent MB-UKA from February 1, 2023, September 2023. was achieved by traditional "two-finger" (Group 26 or measured resection 2, knees)....
To develop novel nomograms for predicting prostate cancer (PCa) and clinically significant (csPCa) in patients with prostate-specific antigen (PSA) < 10 ng/ml PI-RADS v2.1 score ≤ 3. We retrospectively collected data from 327 men PSA 3 June 2020 to 2024 our hospital. Clinical were compared among the scores 1-3 population, 1-2 population. Logistic regression analyses conducted identify independent risk factors PCa or csPCa, subsequently developed. The evaluated via receiver operating curves...
Background: Lynch Syndrome (LS) is an autosomal dominant disease characterized by germline heterozygous mutations in DNA mismatch repair (MMR) genes. High-risk LS patients may proceed to colorectal cancer (CRC). However, the drivers or biomarkers of benign colon tissue approaching malignant CRC are not completely understood. The similarity and difference between LS-related nonLS-related also well interrogated (LS-CRC vs. nonLS-CRC). This study aimed understand cellular changes during...
Osteosarcoma (OS) is the most common bone malignancy in adolescents and has poor clinical outcomes.Protein arginine methyltransferase 5 (PRMT5) recently been shown to be aberrantly expressed various cancers, yet its role OS remains elusive.Here, we found that PRMT5 was overexpressed overexpression predicted outcomes.PRMT5 knockdown significantly triggered pronounced senescence cells, as evidenced by increase senescence-associated β-galactosidase (SA-β-gal)-stained induction of p21...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause morbidity and mortality. Traditional Chinese medicine (TCM) used to treat AECOPD as adjunctive therapy. This study aimed evaluate the efficacy safety TCM formula Xuan Bai Cheng Qi an adjuvant therapy for patients with syndrome type phlegm-heat obstructing lungs. A multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted. total 244 were divided into intervention group (n = 122,...