A5100303262- Pain Mechanisms and Treatments
- Multimodal Machine Learning Applications
- Domain Adaptation and Few-Shot Learning
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neural Network Applications
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Advanced Image and Video Retrieval Techniques
- Pharmacological Effects of Natural Compounds
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Video Analysis and Summarization
- Natural Language Processing Techniques
- Orthopedic Surgery and Rehabilitation
- Human Pose and Action Recognition
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Signaling Pathways in Disease
- Machine Learning and Data Classification
- Topic Modeling
- Neuroscience and Neural Engineering
- Digital Media and Visual Art
- Stress Responses and Cortisol
- Wireless Sensor Networks and IoT
Xuzhou Medical College
2015-2025
Nanjing Drum Tower Hospital
2024-2025
Nanjing Medical University
2025
Nvidia (United States)
2024
Guizhou Normal University
2024
Shanghai Mental Health Center
2024
Beijing Institute of Technology
2023
Shenzhen University
2023
First Hospital of Shijiazhuang
2023
Shanghai University of Medicine and Health Sciences
2016-2022
Abstract Increasing evidence suggests that neuro-immune and neuro-glial interactions are critically involved in chronic pain sensitization. It is well studied how immune/glial mediators sensitize pain, but sensory neurons control neuroinflammation remains unclear. We employed Myd88 conditional knockout (CKO) mice, which was deleted sodium channel subunit Na v 1.8-expressing primary neurons, to examine the unique role of neuronal MyD88 regulating acute possible underlying mechanisms. found...
Emerging evidence has shown that miRNA-mediated gene expression modulation contributes to chronic pain, but its functional regulatory mechanism remains unknown. Here, we found complete Freund's adjuvant (CFA)-induced inflammation pain significantly reduced miRNA-219 (miR-219) in mice spinal neurons. Furthermore, the of CaMKIIγ, an experimentally validated target miR-219, was increased CFA mice. Overexpression miR-219 prevented and reversed thermal hyperalgesia mechanical allodynia neuronal...
Abstract Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like depression-like behaviour. As the ventral pallidum (VP) in BF regulates pain perception emotions, we aim address role VP-derived hyperalgesia behaviour mouse model. In male mice, VP neurons innervate local non-cholinergic modulate downstream basolateral amygdala (BLA) through nicotinic acetylcholine receptors. These are...
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment either one because they exacerbate each other with unknown mechanisms. As posterior insular cortex (PIC) integrates multiple somatosensory emotional information is implicated in or depression, we hypothesize that PIC its projections may contribute to pathophysiology comorbid depression. We show neurons were readily activated by mechanical, thermal, aversive, stressful appetitive stimulation naive...
Chronic pain is still a basic science and clinical challenge. Unraveling of the neurobiological mechanisms involved in chronic will offer novel targets for development therapeutic strategies. It well known that central sensitization anterior cingulate cortex (ACC) plays critical role initiation, development, maintenance pain. However, underlying remain elusive. Here, we reported caveolin-1 (Cav-1), scaffolding protein membrane rafts, was persistently upregulated activated ACC neurons after...
Abstract Increasing evidence suggests that the mesolimbic reward system plays critical roles in regulation of depression and nociception; however, its circuitry cellular mechanisms remain unclear. In this study, we investigated output-specific regulatory dopaminergic (DA) neurons within ventral tegmental area (VTA) depressive-like nociceptive behaviors mice subjected to unpredictable chronic mild stress (CMS), using projection-specific electrophysiological recording, pharmacological...
Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, mechanisms underlying spinal microglial activation during pain remain incompletely determined. Here, we investigated Pellino1 (Peli1) and its interplay with
We present F-VLM, a simple open-vocabulary object detection method built upon Frozen Vision and Language Models. F-VLM simplifies the current multi-stage training pipeline by eliminating need for knowledge distillation or detection-tailored pretraining. Surprisingly, we observe that frozen VLM: 1) retains locality-sensitive features necessary detection, 2) is strong region classifier. finetune only detector head combine VLM outputs each at inference time. shows compelling scaling behavior...
Neurons in the subthalamic nucleus (STN) become hyperactive following nerve injury and promote pain-related responses mice. Considering that anterior cingulate cortex (ACC) is involved pain emotion processing projects to STN, we hypothesize ACC neurons may contribute hyperactivity STN chronic pain. In present study, showed enhanced activity response noxious stimuli alterations emotional states became state established by spared of sciatic (SNI) naïve mice, were activated stimuli, but not...
The aim of this study was to investigate the effects exosomes isolated from human bone marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) and a competitive endogenous RNA (ceRNA) network.Exosomes were BMSCs characterized by transmission electron microscopy (TEM), Nanosight (NTA), western blotting. Chondrocytes treated with interleukin-1β (IL-1β) then transfected exosomes. Cell viability apoptosis determined using Counting Kit-8 (CCK-8) flow cytometry, respectively. Cells IL-1β...
Abstract The locus coeruleus (LC) noradrenergic (NA) neurons regulate pain and depression through their projections to various downstream nuclei. Although GABAergic (GABA) in near the LC (LC‐GABA neurons) provide inhibitory synaptic inputs LC‐NA neurons, it remains unknown whether they are implicated neuropathic comorbid neurons. This study demonstrates that LC‐GABA respond noxious stimuli with enhanced activity, stimulation of these elevates thresholds exerts an anti‐depressant‐like effect...
L‐theanine (γ‐glutamylethylamide), an amino acid component of green tea, has been shown to reduce mental and physical stress, improve memory function. In this study, the antidepressant effect was investigated in mice using forced swim test, tail suspension open‐field test reserpine test. produced antidepressant‐like effect, since administration at doses 1, 4 20 mg/kg for 10 successive days significantly reduced immobility time both compared with control group, without accompanying changes...
Increasing evidence has shown that long noncoding RNAs (lncRNAs) ANRIL may function as oncogenes in various types of malignancies. However, there is still a lack knowledge concerning its role osteosarcoma (OS). In this study, we aimed to investigate the influence on cell proliferation and invasion OS determine association with clinicopathological features patients. The tumor specimens adjacent normal tissues were collected from 57 patients expression level was quantified by RT-qPCR. High...
ABSTRACTMemorial spaces have received increasing attention as dark tourism destinations over the last two decades. Based on stimulus-organism-response theory and of planned behavior, this study proposes a model to measure influence environmental stimuli tourists' behavioral intentions regarding memorial spaces. It also examines mediating roles attitudes, subjective norms, perceptual (perceived) control, affective responses. The results show that direct indirect effect through four individual...
The recently proposed Sharpness-Aware Minimization (SAM) improves generalization by minimizing a \textit{perturbed loss} defined as the maximum loss within neighborhood in parameter space. However, we show that both sharp and flat minima can have low perturbed loss, implying SAM does not always prefer minima. Instead, define \textit{surrogate gap}, measure equivalent to dominant eigenvalue of Hessian at local minimum when radius (to derive loss) is small. surrogate gap easy compute feasible...
The basal ganglia modulate somatosensory pain pathways, but it is unclear whether a common circuit exists to mitigate hyperalgesia in states induced by peripheral nociceptive stimuli. As key output nucleus of the ganglia, substantia nigra pars reticulata (SNr) may be candidate for this role. To test possibility, we optogenetically modulated SNr GABAergic neurons and examined thresholds freely behaving male mice inflammatory neuropathic as well comorbid depression chronic pain. We observed...