A5102926087- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Neurological disorders and treatments
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
Xuzhou Medical College
2021-2024
Abstract Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like depression-like behaviour. As the ventral pallidum (VP) in BF regulates pain perception emotions, we aim address role VP-derived hyperalgesia behaviour mouse model. In male mice, VP neurons innervate local non-cholinergic modulate downstream basolateral amygdala (BLA) through nicotinic acetylcholine receptors. These are...
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment either one because they exacerbate each other with unknown mechanisms. As posterior insular cortex (PIC) integrates multiple somatosensory emotional information is implicated in or depression, we hypothesize that PIC its projections may contribute to pathophysiology comorbid depression. We show neurons were readily activated by mechanical, thermal, aversive, stressful appetitive stimulation naive...
Neurons in the subthalamic nucleus (STN) become hyperactive following nerve injury and promote pain-related responses mice. Considering that anterior cingulate cortex (ACC) is involved pain emotion processing projects to STN, we hypothesize ACC neurons may contribute hyperactivity STN chronic pain. In present study, showed enhanced activity response noxious stimuli alterations emotional states became state established by spared of sciatic (SNI) naïve mice, were activated stimuli, but not...
The basal ganglia including the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) are involved in pain-related responses, but how they regulate pain processing remains unknown. Here, we identify a pathway, consisting of GABAergic neurons SNr (SNrGABA) glutamatergic STN (STNGlu) lateral parabrachial (LPBGlu), that modulates acute persistent states both male female mice. activity was enhanced states. This enhancement accompanied by hypoactivity SNrGABA strengthening STN-LPB...
The basal ganglia modulate somatosensory pain pathways, but it is unclear whether a common circuit exists to mitigate hyperalgesia in states induced by peripheral nociceptive stimuli. As key output nucleus of the ganglia, substantia nigra pars reticulata (SNr) may be candidate for this role. To test possibility, we optogenetically modulated SNr GABAergic neurons and examined thresholds freely behaving male mice inflammatory neuropathic as well comorbid depression chronic pain. We observed...