A5042896705- Head and Neck Cancer Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Tea Polyphenols and Effects
- Immune cells in cancer
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Head and Neck Surgical Oncology
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced biosensing and bioanalysis techniques
- Cancer Mechanisms and Therapy
- Thyroid Cancer Diagnosis and Treatment
- Kruppel-like factors research
- Gastroesophageal reflux and treatments
- Allergic Rhinitis and Sensitization
- Airway Management and Intubation Techniques
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Respiratory and Cough-Related Research
First Affiliated Hospital of Xiamen University
2015-2025
Fujian Medical University
2020-2025
Xiamen University
2019-2024
Anhui Agricultural University
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Chinese Academy of Sciences
2023-2024
Shenzhen Institutes of Advanced Technology
2024
University of Benin
2023
National Natural Science Foundation of China
2018
Oral squamous cell carcinoma (OSCC) is becoming more common across the globe. The prognosis of OSCC largely dependent on early detection. But routine oral cavity examination may delay diagnosis because malignant lesions be clinically indistinguishable from benign or inflammatory diseases. In this study, new diagnostic method developed by using surface enhanced Raman spectroscopy (SERS) to detect serum samples cancer patients. blood were collected patients, MEC patients and volunteers without...
Despite recent advances in the therapy of non-small cell lung cancer (NSCLC), chemotherapy efficacy against NSCLC is still unsatisfactory. Previous studies show herbal antimalarial drug dihydroartemisinin (DHA) displays cytotoxic to multiple human tumors. Here, we showed that DHA decreased viability and colony formation, induced apoptosis A549 PC-9 cells. Additionally, first revealed inhibited glucose uptake Moreover, glycolytic metabolism was attenuated by DHA, including inhibition ATP...
Background: Tumor stages detection and histologic grades classification are essential for the diagnosis prognosis of oral squamous cell carcinoma (OSCC). In this research, we apply surface-enhanced Raman spectroscopy (SERS) blood serum to detect tumor OSCC. Methods: According TNM World Health Organization grading system, samples were collected from a total 135 OSCC patients in different grades. Then SERS spectra diagnosed classified into groups using principal component analysis (PCA) linear...
It is difficult for the parotid gland neoplasms to make an accurate preoperative diagnosis due restriction of biopsy in neoplasms. The aim this study apply surface-enhanced Raman spectroscopy (SERS) method blood serum biochemical detection and use support vector machine analysis order develop a simple but serums were collected from four groups: patients with pleomorphic adenoma, Warthin's tumor, mucoepidermoid carcinoma volunteers without Au nanoparticles (Au NPs) mixed as SERS active...
Esophageal carcinoma (EsC) is a clinically challenging neoplastic disease. Genistein, natural isoflavone product, has anti-tumor properties. Through in vitro and vivo studies, we found that genistein suppressed EsC cell proliferation time- concentration-dependent manner. In addition, markedly promoted apoptosis arrested cycle at the G0/G1 phase Furthermore, high concentrations of have no adverse effect on normal esophageal epithelial cells. Mechanistically, treatment strikingly reduced...
Purpose To evaluate the efficacy and laryngeal function preservation of neoadjuvant treatment with chemotherapy immune checkpoint inhibitor for locally advanced hypopharyngeal cancer (LAHPC). Methods We retrospectively collected LAHPC patients who were diagnosed between February 2022 June 2023. The received a combination inhibitors as therapy. response to treatment, rate, short-term survival assessed. Results A total 20 included. Of these patients, 17 (85.0%) had stage IVA-B disease. Ten...
IP geolocation accuracy heavily relies on the availability of numerous high-quality network landmarks. However, IPv6 faces challenges due to its vast address space and rotating prefixes. Existing landmark mining methods struggle meet stringent demands street-level geolocation. We introduce IPv6Landmarker, a novel approach that enhances precision through targeted updates. By associating WAN addresses with WiFi BSSIDs in wireless routers, we employ multi-association coordinate filtering...
Objective: To investigate the changes in narrow band imaging (NBI) phenotypes of oropharyngeal, hypopharyngeal, and laryngeal squamous cell carcinoma after neoadjuvant immunochemotherapy, to explore clinical value NBI endoscopy re-evaluation follow-up pharyngeal immunochemotherapy. Methods: Twenty-nine patients diagnosed with locally advanced or First Affiliated Hospital Xiamen University from November 2021 January 2024 receiving 2 cycles immunochemotherapy were selected, including 26 males...
Abstract Background Intranasal corticosteroids are the most efficacious anti-inflammatory medications for allergic rhinitis (AR). However, efficacy and safety of intranasal in children have not yet been subject to specific research China. The aim this study was investigate fluticasone furoate nasal spray (FFNS) a Chinese pediatric population. Methods In phase 4 randomized, double-blind, placebo-controlled, multicenter study, AR patients aged 2–12 years were randomized 1:1:1, receiving either...
Background: Integrin subunit α 8 (ITGA8) methylation has been associated with the development of several cancers, but its contribution to breast cancer remains unclear. The present study aimed investigate status ITGA8, and underlying regulatory mechanisms ITGA8 in cancer. Methods: expression was investigated using Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database Breast Cancer Gene-Expression Miner v.4.4 (bc-GenExMiner v4.4). association between levels survival rate patients...
Abstract Background CD74 is ectopically expressed in many tumors and can regulate tumor immunity. However, there are gaps the study of prognostic value expression immune infiltration hepatocellular carcinoma (HCC). Methods An online database was searched to obtain data on gene/protein expression. Immune analysis performed using Tumor Estimation Resource Comprehensive Analysis Multi-Omics Immunotherapy Pan-cancer databases. Single-cell were obtained from Tissue-specific Gene Expression...
The presence of API2/MALT1 fusion in gastric mucosa-associated lymphoid tissue (MALT) lymphoma predicts poor response to Helicobacter pylori (Hp) eradication therapy. This study aimed assess the correlation between endoscopic morphology MALT and evaluate treatment Hp based on morphological subtypes.
Hypercholesterolaemia is one of the risk factors for atherosclerosis and subsequent cardiovascular disease. Here, we investigated effects dietary supplementation with Ilex latifolia or green tea ( Camellia sinensis ) on levels plasma total cholesterol, high‐density lipoprotein cholesterol circulating immune complexes in Sprague Dawley rats fed a high‐cholesterol diet. We demonstrated that daily administration by gavage I. C. at doses 1.0 2.0 g/kg body weight 30 days resulted significant...
The aim of the present study was to investigate expression, distribution and function dendritic cells (DCs) their role in nasal polyps. involved 55 participants, 45 whom had polyps were group 10 who normal inferior turbinates control group. Immunohistochemical staining used visualize expression S-100 protein. A double immunostaining method CD1a CD40 images analyzed with Axioplan 2 microscopy. level protein higher than that a significant difference (P<0.01). area, number density stained all...
-1 d green tea significantly decreased blood pressure and plasma Ang II level, accompanying the improvement of ultra structures left ventricular mitochondrion myofibrillae. It is considered that effect on hypertension might be related to its inhibition angiotensin converting enzyme.
Objective: To evaluate the role of narrow band imaging (NBI) endoscopy in diagnosis laryngeal lesions. Methods: A total 136 patients with lesions were examined by NBI and white light (WLI) from July 2016 to May 2017. Sensitivity, specificity, accuracy, positive predictive value (PPV) negative (NPV) WLI calculated. SPSS 20.0 software was used analyze data. Results: Compared WLI, showed higher sensitivity (94.9% vs 83.3%), specificity (95.6% 84.4%), PPV 82.3%), NPV 85.4%). There high...
Mitochondrial fission depends on dynamin-related protein 1 (Drp1) guanosine triphosphatase activity. Although there is some association between Drp1 and gastric cancer, the detailed mechanism remains largely unknown. In this study, elevation of was observed in human carcinoma specimens including mixed adenocarcinoma tissues, intestinal-type cancer cells compared to normal control, but not diffuse tissues. Gastric patients with high harbored advanced pathological stages poor progression-free...