A5103059610- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Head and Neck Cancer Studies
- Ear Surgery and Otitis Media
- Cancer-related molecular mechanisms research
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Allergic Rhinitis and Sensitization
- Nasal Surgery and Airway Studies
- Head and Neck Anomalies
- Oral and Maxillofacial Pathology
- IL-33, ST2, and ILC Pathways
- Vestibular and auditory disorders
- Mast cells and histamine
- Reconstructive Surgery and Microvascular Techniques
- Respiratory and Cough-Related Research
- Cancer Diagnosis and Treatment
- Spinal Cord Injury Research
- Melanoma and MAPK Pathways
- Cerebrovascular and genetic disorders
- Otitis Media and Relapsing Polychondritis
- Connective tissue disorders research
- Respiratory viral infections research
Hunan Normal University
2012-2024
Hunan Provincial People's Hospital
2009-2024
To determine the relationship between blood serum brain-derived neurotrophic factor (BDNF) level and cognitive function deterioration in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), to explore possible mechanism of impairment.Twenty-eight male OSAHS 14 normal males (as controls) were enrolled study. Polysomnography Montreal assessment (MoCA) conducted. The BDNF levels measured using ELISA.The group had significantly decreased compared control (t = -10.912, P 0.000)....
Abstract Background Intranasal corticosteroids are the most efficacious anti-inflammatory medications for allergic rhinitis (AR). However, efficacy and safety of intranasal in children have not yet been subject to specific research China. The aim this study was investigate fluticasone furoate nasal spray (FFNS) a Chinese pediatric population. Methods In phase 4 randomized, double-blind, placebo-controlled, multicenter study, AR patients aged 2–12 years were randomized 1:1:1, receiving either...
Allergic rhinitis (AR) is a nasal mucosal inflammatory disease mediated by environmental allergens. At present, the relationship between IL-33/ST2 axis, ERK1/2 pathway and AR progression needs further exploration. In our study, an model was constructed in vitro treating HNEpC cells with Der p1. qRT-PCR applied to assess mRNA levels of IL-33, ST2, TNF-α, IL-6, IL-8. Western blotting used measure protein downstream proteins p-ERK1/2, ERK1/2, p-RSK, RSK. IL-8, TNF-α cell supernatants were...
Abstract Clinical translation of poly (lactic-co-glycolic acid) (PLGA)-based nanomedicine is limited, partly because the poor delivery efficiency resulting from non-specific phagocytosis by phagocytes. Understanding nanoparticle interplay between cancer cells and immune remains largely elusive. In this study, a quantitative investigation on cellular internalization fluorescent PLGA particles (100 nm, 500 1 µm) against laryngeal carcinoma with or without monocytes/macrophages in monoculture...
Melanoma is the main cause of death in patients with skin cancer. While pathogenesis cutaneous melanoma poorly understood, increasing evidence shows that epidermal growth factor (EGF) may be involved. Herein, we tested hypothesis down-regulation EGFL7 inhibits development and progression human (CM). Initially, performed immunohistochemical analysis 130 specimens findings indicated was highly expressed CM. The expressions Notch signaling pathway-related genes CM were then measured by reverse...
Introduction Oxidative stress plays a pivotal role in modulating the balance of intestinal flora and gut-liver axis, while also serving as key determinant growth potential weaned piglets. However, few studies have subdivided compared acute chronic oxidative stress. Methods In this study, an model piglets using paraquat (PQ) D-galactosa were conducted. And we further systematically compare their effects. Results Both models impaired barrier function liver function. Chronic caused by...
MicroRNAs (miRNAs) play powerful roles in immune function by regulating target genes that mediate cell behavior. It is well known mast cells have essential effector and regulatory functions IgE-associated allergic disorders innate adaptive responses. However, the role of miRNAs mediating relevant mechanisms require further exploration. The miR-33b airway inflammation are still unknown. To examine mouse cockroach allergen-induced asthma, we developed a lentiviral system for miRNA-33b...
MiRNAlet-7a is associated with the tumorigenesis of laryngeal squamous cell carcinoma (LSCC). Our study was designed to infer whether let-7a targets high-mobility AT-hook 2 (HMGA2) and suppresses proliferation, invasion, migration. The expression levels HMGA2 were measured in 30 LSCC clinical specimens by qRT-PCR their correlation analyzed. Cell model mice xenograft or without overexpression constructed evaluate effects on LSCC. Moreover, luciferase assay performed reveal interaction between...
To study the difference of postoperative efficacy between two-person three-hand ear endoscopy and microscopic tympanoplasty in patients with chronic suppurative otitis media, to explore advantages disadvantages endoscopy.
Objective Studies on feeling of ear fullness (FEF) related to sudden sensorineural hearing loss(SSNHL) are limited. The mechanisms FEF unclear. This study aimed explore the characteristics and brain activation SSNHL with FEF. Methods A total 269 patients were prospectively observed divided into two groups, without Fifteen 20 healthy controls (HCs) recruited underwent 18F-SynVesT-1 static PET. Standardized uptake values ratios (SUVr) computed between regions interest. Results occurrence was...
Compare the difference of Pharyngocutaneous fistula after total laryngectomy using thyroid gland flap and traditional strip muscle repair, find an effective way to reduce laryngectomy.
Objective: To investigate the diagnostic value of serum miRNAlet-7a in laryngeal carcinoma and effect let-7a on proliferation apoptosis cells. Methods: Real-time quantitative PCR was used to determine expression level miRNAlet-7a. The miRNA mimetic synthesized transiently transfected into Hep-2 cell line by cationic liposome method. effects up-regulation cancer cells were detected FCM MTT assays,respectively. association levels with for analyzed. Measurement data taken t test or analysis...
This study aimed to investigate the status of current knowledge about laryngopharyngeal reflux disease (LPRD) among Chinese otolaryngologists.Multi-centre cross-sectional survey.220 medical centres in different regions China.A total 2254 otolaryngologists from 220 China who were successfully on-site surveyed between November 2019 and December 2020.Awareness LPRD included risk factors, symptoms, laryngoscope signs, related diseases, diagnostic methods treatments.The percentage participants...
Objective:To explore the clinical efficacy of transcanal endoscopic ear surgery in diagnosis and treatment conductive hearing loss with intact tympanic membrane. Method:The data 16 patients membrane were retrospectively analyzed. They diagnosed treated by surgery. Result:All exploratory tympanotomy, including 6 cases congenital middle anomalies, 5 cholesteatoma, 2 anomalies otosclerosis, 1 case traumatic ossicular chain disruption. During exploration surgery, different methods reconstruction...
Laryngeal cancer has become the focus of research because its high incidence rate and mortality rate. However, on microRNA-194-5p in laryngeal is quite rare. The purpose this study to explore effect proliferation invasion cells, order find an effective way treat cancer. results showed that could activate mammalian target rapamycin signaling pathway by regulating expression smad ubiquitin regulatory factor 1, which had cells. absorbance group was 0.38 lower than negative control group,...
Children with obstructive sleep apnea hypopnea syndrome (OSAHS) and the upper airway cough (UACS), as respiratory tract disease, there are more things in common, current knowledge of two kinds disease gradually deepened, but both correlation merger related reports research diagnosis treatment diseases rare, so this paper will discuss epidemiology, etiology make a give for review. Key words: Child; Sleep Apnea, Obstructive; Upper Airway; Cough