A5058228792- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Animal Virus Infections Studies
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- RNA Interference and Gene Delivery
- Vibrio bacteria research studies
- Viral Infections and Vectors
- Protease and Inhibitor Mechanisms
- Studies on Chitinases and Chitosanases
- Polysaccharides Composition and Applications
- Immune Cell Function and Interaction
- Crustacean biology and ecology
- Gut microbiota and health
- Neurobiology and Insect Physiology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Polysaccharides and Plant Cell Walls
- Cell Adhesion Molecules Research
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2019-2025
Sun Yat-sen University
2016-2025
Tianjin Medical University
2025
Tianjin University
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2019-2024
Beihang University
2024
Jiangnan University
2017-2023
Hunan Normal University
2017-2019
Hunan Provincial People's Hospital
2017-2019
Sun Yat-sen University Cancer Center
2018
C-type lectins play key roles in pathogen recognition, innate immunity, and cell-cell interactions. Here, we report a new lectin (C-type 1) from the shrimp Litopenaeus vannamei (LvCTL1), which has activity against white spot syndrome virus (WSSV). LvCTL1 is 156-residue polypeptide containing carbohydrate recognition domain with an EPN (Glu(99)-Pro(100)-Asn(101)) motif that predicted ligand binding specificity for mannose. Reverse transcription-PCR analysis revealed mRNA was specifically...
Background Pacific white shrimp (Litopenaeus vannamei), the major species of farmed shrimps in world, has been attracting extensive studies, which require more and genome background knowledge. The now available transcriptome data L. vannamei are insufficient for research requirements, have not adequately assembled annotated. Methodology/Principal Findings This is first study that used a next-generation high-throughput DNA sequencing technique, Solexa/Illumina GA II method, to analyze from...
Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate wound healing repair injured tissues. C57BL/6 female mice divided into control ozone oil treated groups. Excisional wounds made on dorsal skin isolated from granulation The mouse model revealed that could significantly decrease area accelerate compared with group....
Abstract There is a debate on whether invertebrates possess an antiviral immunity similar to the interferon (IFN) system of vertebrates. The Vago gene from arthropods encodes viral-activated secreted peptide that restricts virus infection through activating JAK-STAT pathway and considered be cytokine functionally IFN. In this study, first crustacean IFN regulatory factor (IRF)-like was identified in Pacific white shrimp, Litopenaeus vannamei . L. IRF showed protein nature mammalian IRFs...
Abstract In the evolutionarily conserved canonical NF-κB pathway, degradation of inhibitor IκB in cytoplasmic NF-κB/IκB complex allows liberated to translocate into nucleus activate various target genes. The regulatory mechanism governing this process needs further investigation. study, a novel microRNA, temporarily named miR-1959, was first identified from an invertebrate Litopenaeus vannamei. miR-1959 targets 3′-untranslated region homolog Cactus gene and reduces protein level vivo,...
The nuclear factor-kappa B (NF-κB) pathways play important roles in innate immune responses. IκB is the main cytoplasmic inhibitor of NF-κB. In this study, we identified LvCactus gene from Litopenaeus vannamei, which first cloned homologue subphylum Crustacea. contains six predicted ankyrin repeats, show similarities to those Cactus proteins insects. localizes cytoplasm and interacts with LvDorsal, an L. vannamei Drosophila melanogaster Dorsal belonging class II NF-κB family, prevent its...
c-Jun NH2-terminal kinase/stress-activated kinase (JNK/SAPK) and the p38 mitogen-activated protein (p38 MAPK) are important components of cellular signal transduction pathways, which have been reported to be involved in viral replication. However, little is known about JNK1/2 MAPK signaling pathways enterovirus 71 (EV71)-infected immature dendritic cells (iDCs). Thus, iDCs were induced from peripheral blood mononuclear (PBMC) performed explore expressions phosphorylation molecules two as...
Uncontrolled immune responses resulting from overactivated cellular signaling pathways, leading to inflammation and tissue injury, are a major cause of death in pathogen-infected individuals. This phenomenon has been well studied mammals but is less explored invertebrates. Bacteria the genus Vibrio among most harmful pathogens humans aquatic animals. In shrimp, infection generally characterized by sudden onset disease, with pathological signs opaque whitish muscle tissue. The current study...